Microvessel Density But Not Neoangiogenesis Is Associated with 18F-FDG Uptake in Human Atherosclerotic Carotid Plaques

[1]  H. Sillesen,et al.  When to image carotid plaque inflammation with FDG PET/CT , 2010, Nuclear medicine communications.

[2]  H. Sillesen,et al.  Gene expression and 18FDG uptake in atherosclerotic carotid plaques , 2010, Nuclear medicine communications.

[3]  V. Nizet,et al.  Interdependence of hypoxic and innate immune responses , 2009, Nature Reviews Immunology.

[4]  A. Harris,et al.  Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. , 2009, Blood.

[5]  A. Walch,et al.  Evaluation of &agr;v&bgr;3 Integrin-Targeted Positron Emission Tomography Tracer 18F-Galacto-RGD for Imaging of Vascular Inflammation in Atherosclerotic Mice , 2009, Circulation. Cardiovascular imaging.

[6]  Z. Galis,et al.  Will the real plaque vasculature please stand up? Why we need to distinguish the vasa plaquorum from the vasa vasorum. , 2009, Trends in cardiovascular medicine.

[7]  P. V. van Diest,et al.  HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages. , 2007, Atherosclerosis.

[8]  A. Mobasheri,et al.  Hypoxic Regulation of Glucose Transport, Anaerobic Metabolism and Angiogenesis in Cancer: Novel Pathways and Targets for Anticancer Therapeutics , 2007, Chemotherapy.

[9]  Ahmed Tawakol,et al.  In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. , 2006, Journal of the American College of Cardiology.

[10]  Claus Lindbjerg Andersen,et al.  Normalization of Real-Time Quantitative Reverse Transcription-PCR Data: A Model-Based Variance Estimation Approach to Identify Genes Suited for Normalization, Applied to Bladder and Colon Cancer Data Sets , 2004, Cancer Research.

[11]  F. Kolodgie,et al.  Regulation of Macrophage Foam Cell Formation by αVβ3 Integrin : Potential Role in Human Atherosclerosis , 2004 .

[12]  B. Uzzan,et al.  Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysis. , 2004, Cancer research.

[13]  L. Neckers,et al.  IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis , 2003 .

[14]  P. Carmeliet Angiogenesis in health and disease , 2003, Nature Medicine.

[15]  J. Pickard,et al.  Imaging Atherosclerotic Plaque Inflammation With [18F]-Fluorodeoxyglucose Positron Emission Tomography , 2002, Circulation.

[16]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[17]  M. Dake,et al.  Vascular endothelial growth factor enhances atherosclerotic plaque progression , 2001, Nature Medicine.

[18]  Sibylle Ziegler,et al.  Noninvasive Imaging of αvβ3 Integrin Expression Using 18F-labeled RGD-containing Glycopeptide and Positron Emission Tomography , 2001 .

[19]  W. Jelkmann,et al.  Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1 , 1999 .

[20]  D. Woolley,et al.  Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries , 1999, The Journal of pathology.

[21]  O. Wiklund,et al.  Evidence of hypoxic areas within the arterial wall in vivo. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[22]  A. Becker,et al.  Leucocyte recruitment in rupture prone regions of lipid-rich plaques: a prominent role for neovascularization? , 1999, Cardiovascular research.

[23]  M. Kuzuya,et al.  Induction of macrophage VEGF in response to oxidized LDL and VEGF accumulation in human atherosclerotic lesions. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[24]  W. Risau,et al.  Mechanisms of angiogenesis , 1997, Nature.

[25]  Takayuki Asahara,et al.  Isolation of Putative Progenitor Endothelial Cells for Angiogenesis , 1997, Science.

[26]  M. Detmar,et al.  Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin. , 1996, The American journal of pathology.

[27]  Lieve Moons,et al.  Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele , 1996, Nature.

[28]  Kenneth J. Hillan,et al.  Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene , 1996, Nature.

[29]  C. Alpers,et al.  αvβ3 Integrin Expression in Normal and Atherosclerotic Artery , 1995 .

[30]  K. Sueishi,et al.  Intimal neovascularization in human coronary atherosclerosis: its origin and pathophysiological significance. , 1995, Human pathology.

[31]  D. Cheresh,et al.  Requirement of vascular integrin alpha v beta 3 for angiogenesis. , 1994, Science.

[32]  E. Keshet,et al.  Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis , 1992, Nature.

[33]  M. Greaves,et al.  Expression of the CD34 gene in vascular endothelial cells. , 1990, Blood.

[34]  J. Griffiths,et al.  The altered metabolism of tumors: HIF-1 and its role in the Warburg effect. , 2010, Advances in enzyme regulation.

[35]  F. Kolodgie,et al.  Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis. , 2004, The American journal of pathology.

[36]  Yun-Jin Jung,et al.  IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[37]  M. Schwaiger,et al.  Noninvasive imaging of alpha(v)beta3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography. , 2001, Cancer research.

[38]  C. Alpers,et al.  Alpha-v beta-3 integrin expression in normal and atherosclerotic artery. , 1995, Circulation research.