COMPARATIVE EVALUATION OF REMINERALIZING POTENTIAL OF DIFFERENT COMMERCIALLY AVAILABLE REMINERALIZING AGENTS : AN IN VITRO SCANNING ELECTRON MICROSCOPY/EDS STUDY

Background - Modern dentistry aims at non-invasive & biological approach using remineralizing agents for management of early carious lesion. Aim- To evaluate and compare the remineralizing potential of three commercially available remineralizing agents containing SDF(Fagamin), CPP-ACPF(GC Tooth Mousse Plus) and BiominF(Elsenz) on demineralized enamel. Material and methods- Samples from forty extracted premolar teeth were selected and subjected to demineralizing solution for 96 hrs to create white spot lesion. The demineralized samples were randomly allocated into four groups:Group I(control group), Group II(SDF),Group III(CPPACPF),Group IV(Elsenz). White spot lesion containing demineralized samples were subjected to the test agents for 5 minutes everyday for 30 days. Scanning electron microscope (SEM) and Energy dispersive Spectroscopy (EDS) analysis were carried out at pre-remineralization and post-remineralization stage. The data were analyzed using SPSS 19.0 software Statistical Analysis- with one-way ANOVA and paired t-test. Results- All three test agents showed signicant remineralization of previously demineralized lesions. However, Elsenz showed the greatest remineralization, followed by SDF and then CPP-ACPF paste. Elsenz proved to be Conclusion- the best remineralizing agent and can be strongly recommended as an alternative to other remineralizing agents used in this study.

[1]  Meghana,et al.  Comparative evaluation of Elsenz and GC tooth mousse in remineralization of enamel – a clinical study , 2022, International Journal of Pedodontic Rehabilitation.

[2]  A. Tikku,et al.  Comparative evaluation of remineralizing effect of fluoride and nonfluoride agents on artificially induced caries using different advanced imaging techniques , 2022, Journal of conservative dentistry : JCD.

[3]  A. Abo El Soud,et al.  Comparative Evaluation of Remineralizing Effect of Casein Phosphopeptide – Amorphous Calcium Phosphate Fluoride and Silver Diamine Fluoride on Demineralized Enamel Surfaces ( An In Vitro Study) , 2021, Dental Science Updates.

[4]  N. Srikant,et al.  Comparative evaluation of three different toothpastes on remineralization potential of initial enamel lesions: A scanning electron microscopic study , 2020, Indian journal of dental research : official publication of Indian Society for Dental Research.

[5]  Darshana Vinod,et al.  A Comparative Evaluation of Remineralizing Potential of Three Commercially Available Remineralizing Agents: An In Vitro Study , 2020, International journal of clinical pediatric dentistry.

[6]  P. Kabra,et al.  Assessment of enamel remineralising capability of three different remineralising agents using vicker’s surface microhardness test. , 2019, International Journal of pharma and Bio Sciences.

[7]  L. Temmerman,et al.  The in vitro remineralizing effect of CPP-ACP and CPP-ACPF after 6 and 12 weeks on initial caries lesion , 2019, Journal of applied oral science : revista FOB.

[8]  Quanli Li,et al.  Remineralisation of enamel with silver diamine fluoride and sodium fluoride. , 2018, Dental materials : official publication of the Academy of Dental Materials.

[9]  D. Elkassas,et al.  Comparative evaluation of remineralizing efficacy of biomimetic self-assembling peptide on artificially induced enamel lesions: An in vitro study , 2018, Journal of conservative dentistry : JCD.

[10]  M. Fernandes,et al.  Assessment of Enamel Remineralisation After Treatment with Four Different Remineralising Agents: A Scanning Electron Microscopy (SEM) Study. , 2017, Journal of clinical and diagnostic research : JCDR.

[11]  V. Gade Comparative evaluation of remineralization efficacy of GC tooth mousse plus and enafix on artificially demineralized enamel surface: An in vitro study , 2016 .

[12]  R. Somani,et al.  Remineralizing potential of various agents on dental erosion. , 2014, Journal of oral biology and craniofacial research.

[13]  V. Kumari,et al.  Remineralization potential of bioactive glass and casein phosphopeptide-amorphous calcium phosphate on initial carious lesion: An in-vitro pH-cycling study , 2014, Journal of conservative dentistry : JCD.

[14]  K. S. Satheesh Kumar,et al.  Remineralization efficiency of bioactive glass on artificially induced carious lesion an in-vitro study. , 2014, Journal of the Indian Society of Pedodontics and Preventive Dentistry.

[15]  B. Nandlal,et al.  Comparative evaluation of remineralization potential of casein phosphopeptide-amorphous calcium phosphate and casein phosphopeptide-amorphous calcium phosphate fluoride on artificial enamel white spot lesion: an in vitro light fluorescence study. , 2013, Indian journal of dental research : official publication of Indian Society for Dental Research.

[16]  Quanli Li,et al.  Antibacterial effects of silver diamine fluoride on multi-species cariogenic biofilm on caries , 2013, Annals of Clinical Microbiology and Antimicrobials.

[17]  A. Logani,et al.  Remineralizing efficacy of silver diamine fluoride and glass ionomer type VII for their proposed use as indirect pulp capping materials – Part II (A clinical study) , 2011, Journal of conservative dentistry : JCD.

[18]  Vikram Sharma,et al.  Tooth remineralization using bio-active glass - A novel approach , 2011 .

[19]  E. Reynolds,et al.  Remineralization of Enamel Subsurface Lesions by Casein Phosphopeptide-stabilized Calcium Phosphate Solutions , 1997, Journal of dental research.