The potential of Zr-based bulk metallic glasses as biomaterials

Zr-based bulk metallic glasses (BMGs) are a new type of metallic materials with disordered atomic structure that exhibit high strength and high elastic strain, relatively low Young’s modulus, and excellent corrosion resistance and biocompatibility. The combination of these unique properties makes the Zr-based BMGs very promising for biomaterials applications. In this review article, the authors give an overview of the recent progress in the study of biocompatibility of Zr-based BMGs, especially the relevant work that has been done in the metallic glasses group in Huazhong University of Science and Technology (HUST), including the development of Ni-free Zr-based BMGs, the mechanical and wear properties, the bio-corrosion resistance, the in vitro and in vivo biocompatibility and the bioactive surface modification of these newly developed BMGs.

[1]  Y. Yu,et al.  Bio-activation of Ni-free Zr-based bulk metallic glass by surface modification , 2010 .

[2]  A. Inoue,et al.  Al–La–Ni Amorphous Alloys with a Wide Supercooled Liquid Region , 1989 .

[3]  M. Morrison,et al.  The electrochemical evaluation of a Zr-based bulk metallic glass in a phosphate-buffered saline electrolyte. , 2005, Journal of biomedical materials research. Part A.

[4]  T. Hanawa,et al.  Effect of chloride ion on the anodic polarization behavior of the Zr65Al7.5Ni10Cu17.5 amorphous alloy in phosphate buffered solution , 2000 .

[5]  A. Inoue.  Stabilization of metallic supercooled liquid and bulk amorphous alloys , 2000 .

[6]  Keith C. C. Chan,et al.  Enhanced plasticity by phase separation in CuZrAl bulk metallic glass with micro-addition of Fe , 2009 .

[7]  Peter J. Blau,et al.  Friction and wear of a Zr-based amorphous metal alloy under dry and lubricated conditions , 2001 .

[8]  Akihisa Inoue,et al.  Stabilization and high strain-rate superplasticity of metallic supercooled liquid , 1999 .

[9]  P. Uggowitzer,et al.  Tensile properties of glassy MgZnCa wires and reliability analysis using Weibull statistics , 2009 .

[10]  Shengmin Zhang,et al.  Surface modification and biocompatibility of Ni-free Zr-based bulk metallic glass , 2008 .

[11]  Takao Hanawa,et al.  Effects of surface finishing and dissolved oxygen on the polarization behavior of Zr65Al7.5Ni10Cu17.5 amorphous alloy in phosphate buffered solution , 2000 .

[12]  C. Qiu,et al.  Deformation behavior, corrosion resistance, and cytotoxicity of Ni-free Zr-based bulk metallic glasses. , 2008, Journal of biomedical materials research. Part A.

[13]  S. Tosatti,et al.  Cytotoxicity of Zr-based bulk metallic glasses , 2006 .

[14]  K. Chan,et al.  The effect of the addition of ta on the structure, crystallization and mechanical properties of Zr-Cu-Ni-Al-Ta bulk metallic glasses , 2007 .

[15]  F. Luborsky.  Chapter 1 – Amorphous metallic alloys , 1983 .

[16]  Lin Liu,et al.  Enhancement of glass-forming ability and bio-corrosion resistance of Zr–Co–Al bulk metallic glasses by the addition of Ag , 2010 .

[17]  T. Hanawa,et al.  Fretting Fatigue Properties of Zr-Based Bulk Amorphous Alloy in Phosphate-Buffered Saline Solution , 2002 .

[18]  T. Hanawa,et al.  Effect of pH on the polarization behavior of Zr65Al7.5Ni10Cu17.5 amorphous alloy in a phosphate-buffered solution , 2000 .

[19]  C. Qiu,et al.  Biocompatibility of Ni-free Zr-based bulk metallic glasses , 2009 .

[20]  T. Hanawa,et al.  Re-passivation current of amorphous Zr65Al7.5Ni10Cu17.5 alloy in a Hanks’ balanced solution , 2002 .

[21]  Jan Schroers,et al.  Ductile bulk metallic glass. , 2004, Physical review letters.

[22]  P. Uggowitzer,et al.  MgZnCa glasses without clinically observable hydrogen evolution for biodegradable implants. , 2009, Nature materials.

[23]  C. Qiu,et al.  Improvements in the plasticity and biocompatibility of Zr–Cu–Ni–Al bulk metallic glass by the microalloying of Nb , 2007 .

[24]  C. Qiu,et al.  A novel Ni-free Zr-based bulk metallic glass with enhanced plasticity and good biocompatibility , 2006 .

[25]  Douglas C. Hofmann,et al.  Designing metallic glass matrix composites with high toughness and tensile ductility , 2008, Nature.

[26]  I. Aksay,et al.  Continuous crystalline carbonate apatite thin films. A biomimetic approach. , 2001, Journal of the American Chemical Society.

[27]  M. Morrison,et al.  Cyclic-anodic-polarization studies of a Zr41.2Ti13.8Ni10Cu12.5Be22.5 bulk metallic glass , 2004 .

[28]  P. Duwez,et al.  Non-crystalline Structure in Solidified Gold–Silicon Alloys , 1960, Nature.

[29]  Weihua Wang,et al.  Bulk metallic glasses , 2004 .

[30]  R. Baan,et al.  Evaluation of the carcinogenic risks to humans associated with surgical implants and other foreign bodies - a report of an IARC Monographs Programme Meeting. International Agency for Research on Cancer. , 2000, European journal of cancer.

[31]  W. Johnson,et al.  A highly processable metallic glass: Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 , 1993 .

[32]  J. Horton,et al.  Biomedical Potential of a Zirconium-Based Bulk Metallic Glass , 2002 .

[33]  Tsuyoshi Masumoto,et al.  Workability of the supercooled liquid in the Zr65Al10Ni10Cu15 bulk metallic glass , 1998 .

[34]  J. F. Löffler,et al.  Bulk metallic glass formation in Zr-Cu-Fe-Al alloys , 2005 .

[35]  C. Qiu,et al.  The effect of Nb addition on mechanical properties, corrosion behavior, and metal-ion release of ZrAlCuNi bulk metallic glasses in artificial body fluid. , 2005, Journal of biomedical materials research. Part A.

[36]  J. Wataha,et al.  Effect of silver, copper, mercury, and nickel ions on cellular proliferation during extended, low-dose exposures. , 2000, Journal of biomedical materials research.

[37]  Lin Liu,et al.  Enhanced glass forming ability and plasticity of a Ni-free Zr-based bulk metallic glass , 2009 .

[38]  W. L. Johnson,et al.  A highly processable metallic glass: Zr[sub 41. 2]Ti[sub 13. 8]Cu[sub 12. 5]Ni[sub 10. 0]Be[sub 22. 5] , 1993 .

[39]  Gang Wang,et al.  Super Plastic Bulk Metallic Glasses at Room Temperature , 2007, Science.

[40]  W. Johnson.  Bulk Glass-Forming Metallic Alloys: Science and Technology , 1999 .