Cytomics and nanobioengineering

The finding that an individual's genome differs as much as by many million variants from that of the human reference assembly diminished the great enthusiasm that every disease could be predicted based on nucleotide polymorphisms. Even individual cells of an organ may be specifically equipped to perform specific tasks and that the information of individual cells in a cell system is key information to understand function or dysfunction. Therefore, cytomics received great attention during the last years as it allows to quantitatively and qualitatively analyzing great number of individual cells, cell constituents, and of their intracellular and functional interactions in a cellular system and also giving the concept of analysis of these data.

[1]  A. Beck‐Sickinger,et al.  Microelectrode chip based real time monitoring of vital MCF-7 mamma carcinoma cells by impedance spectroscopy. , 2008, Biosensors & bioelectronics.

[2]  G. Luker,et al.  Applications of bioluminescence imaging to antiviral research and therapy: multiple luciferase enzymes and quantitation. , 2008, Antiviral research.

[3]  Michael Fischer,et al.  Drug testing on 3D in vitro tissues trapped on a microcavity chip. , 2008, Lab on a chip.

[4]  Michael Fischer,et al.  Microcavity array (MCA)-based biosensor chip for functional drug screening of 3D tissue models. , 2008, Biosensors & bioelectronics.

[5]  Z. Darżynkiewicz,et al.  Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation , 2008, Cell cycle.

[6]  János Szöllosi,et al.  Seeing through protein complexes by high‐throughput FRET , 2008, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[7]  J. Lupski,et al.  The complete genome of an individual by massively parallel DNA sequencing , 2008, Nature.

[8]  M. Olson.  Human genetics: Dr Watson's base pairs , 2008, Nature.

[9]  Andreas Thiel,et al.  From transcriptome to cytome: Integrating cytometric profiling, multivariate cluster, and prediction analyses for a phenotypical classification of inflammatory diseases , 2008, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[10]  J. Paul Robinson,et al.  Automated classification of bacterial particles in flow by multiangle scatter measurement and support vector machine classifier , 2008, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[11]  A. Gerstner,et al.  Zytomik und prädiktive Medizin in der Onkologie , 2008, HNO.

[12]  B. Christ,et al.  Hepatocytes derived from adult stem cells. , 2008, Transplantation proceedings.

[13]  S. Müller.  Cytomics reaches microbiology—Population heterogeneity on the protein level caused by chemical stress , 2008, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[14]  M. Harnett,et al.  Inverse Rap1 and Phospho-ERK Expression Discriminate the Maintenance Phase of Tolerance and Priming of Antigen-Specific CD4+ T Cells In Vitro and In Vivo1 , 2007, The Journal of Immunology.

[15]  Kathryn E. Luker,et al.  Optical Imaging: Current Applications and Future Directions , 2007, Journal of Nuclear Medicine.

[16]  F. Emmrich,et al.  Characterization of dendritic cell subsets in patients undergoing renal transplantation. , 2007, Transplantation proceedings.

[17]  M. Harnett,et al.  Laser scanning cytometry: understanding the immune system in situ , 2007, Nature Reviews Immunology.

[18]  Z. Darżynkiewicz,et al.  Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging‐related processes , 2007, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[19]  T. Pengo,et al.  Computer Assisted Detection of Cancer Cells in Minimal Samples of Lung Cancer , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[20]  Daniel J. Muller,et al.  Studying Integrin-Mediated Cell Adhesion at the Single-Molecule Level Using AFM Force Spectroscopy , 2007, Science's STKE.

[21]  Walter Schubert,et al.  Breaking the biological code , 2007, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[22]  Timothy B. Stockwell,et al.  The Diploid Genome Sequence of an Individual Human , 2007, PLoS biology.

[23]  A. Berner,et al.  Flow cytometric immunphenotyping of epithelial cancer cells in effusions—Technical considerations and pitfalls , 2007, Cytometry. Part B, Clinical cytometry.

[24]  Z. Darżynkiewicz,et al.  Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents , 2007, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[25]  M. Shenkin,et al.  Accurate assessment of cell count and viability with a flow cytometer , 2007, Cytometry. Part B, Clinical cytometry.

[26]  S. Müller,et al.  Isolation of intact RNA from cytometrically sorted Saccharomyces cerevisiae for the analysis of intrapopulation diversity of gene expression , 2007, Nature Protocols.

[27]  Martin Weigert,et al.  Automatic Analysis of Immunofluorescence Patterns of HEp‐2 Cells , 2007, Annals of the New York Academy of Sciences.

[28]  Arkadiusz Pierzchalski,et al.  Observing the invisible: Molecular and cellular imaging by multimodal virtual anatomy , 2007, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[29]  B. Christ,et al.  Hepatocyte differentiation of mesenchymal stem cells from rat peritoneal adipose tissue in vitro and in vivo. , 2007, Experimental cell research.

[30]  R. A. Zoroofi,et al.  An image analysis approach for automatic malignancy determination of prostate pathological images , 2007, Cytometry. Part B, Clinical cytometry.

[31]  H. Ozdogu,et al.  The apoptosis of blood polymorphonuclear leukocytes in sickle cell disease , 2007, Cytometry. Part B, Clinical cytometry.

[32]  A. Tárnok.  Cytomics and translational medicine: Preface to the abstracts of the 12th Leipziger Workshop incorporating the 5th International Workshop on Slide Based Cytometry , 2007 .

[33]  Paul J Smith,et al.  Cytomics and drug development , 2007, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[34]  Attila Tárnok,et al.  Inflammation and Immune Suppression following Protein Losing Enteropathy after Fontan Surgery Detected by Cytomics , 2007, Transfusion Medicine and Hemotherapy.

[35]  J. Gummert,et al.  Biomarkers in Transplantation Medicine: Prediction of Pharmacodynamic Drug Effects , 2007, Transfusion Medicine and Hemotherapy.

[36]  Jens Friedrichs,et al.  Revealing Early Steps of α2β1 Integrin-mediated Adhesion to Collagen Type I by Using Single-Cell Force Spectroscopy , 2007 .

[37]  P. Petit,et al.  Cardiolipin deficiency releases cytochrome c from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis , 2007, Cell Death and Differentiation.

[38]  J. O'connor,et al.  Cytomics: A multiparametric, dynamic approach to cell research. , 2007, Toxicology in vitro : an international journal published in association with BIBRA.

[39]  J. Garbade,et al.  Pharmacodynamics of T‐cell function for monitoring immunosuppression , 2007, Cell proliferation.

[40]  Michael J Cima,et al.  Combination of automated high throughput platforms, flow cytometry, and hierarchical clustering to detect cell state , 2007, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[41]  A. Tárnok,et al.  Cytomics – importance of multimodal analysis of cell function and proliferation in oncology , 2006, Cell proliferation.

[42]  F. Powrie,et al.  Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis1 , 2006, The Journal of Immunology.

[43]  M. Schmidt,et al.  Real-time measurement of PMA-induced cellular alterations by microelectrode array-based impedance spectroscopy. , 2006, BioTechniques.

[44]  F. Mohr,et al.  The Influence of Immunosuppressive Drugs on T- and B-cell Apoptosis via p53-Mediated Pathway In Vitro and In Vivo , 2006, Transplantation.

[45]  Attila Tárnok,et al.  Slide‐based cytometry for cytomics—A minireview , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[46]  Attila Tárnok,et al.  Hyperchromatic cytometry principles for cytomics using slide based cytometry , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[47]  Richard M Levenson,et al.  Spectral imaging perspective on cytomics , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[48]  Timo Betz,et al.  Versatile optical manipulation system for inspection, laser processing, and isolation of individual living cells , 2006 .

[49]  Daniel J. Muller,et al.  A new technical approach to quantify cell-cell adhesion forces by AFM. , 2006, Ultramicroscopy.

[50]  M. Harnett.  B Cells Spread and Gather , 2006, Science.

[51]  O. Legrand,et al.  JC‐1, a sensitive probe for a simultaneous detection of P‐glycoprotein activity and apoptosis in leukemic cells , 2006, Cytometry. Part B, Clinical cytometry.

[52]  J. Vial,et al.  Remission induction chemotherapy induces in vivo caspase‐dependent apoptosis in bone marrow acute myeloid leukemia blast cells and spares lymphocytes , 2006, Cytometry. Part B, Clinical cytometry.

[53]  J. Paul Robinson,et al.  Feature extraction from light-scatter patterns of Listeria colonies for identification and classification. , 2006, Journal of biomedical optics.

[54]  W. Schubert.  Cytomics in characterizing Toponomes: Towards the biological code of the cell , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[55]  W. M. Leevy,et al.  Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources. , 2006, Analytical chemistry.

[56]  L. Benes,et al.  Immune surveillance of the human central nervous system (CNS): Different migration pathways of immune cells through theblood–brain barrier and blood–cerebrospinal fluid barrier in healthy persons , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[57]  U. Sack,et al.  Automated four‐color analysis of leukocytes by scanning fluorescence microscopy using quantum dots , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[58]  H. Harms,et al.  Analysis of living S. cerevisiae cell states—A three color approach , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[59]  Ursula Anderer,et al.  Establishment of HEp‐2 cell preparation for automated analysis of ANA fluorescence pattern , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[60]  Attila Tárnok,et al.  Transient Th1/Th2 disbalance indicates postoperative effusions and edema after cardiopulmonary bypass in children , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[61]  U. Sack,et al.  Novel aspects of systems biology and clinical cytomics , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[62]  Johan Geysen,et al.  Cytomics and drug discovery , 2006, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[63]  B. S. Dwarakanath,et al.  Flow‐cytometric analysis of reactive oxygen species in peripheral blood mononuclear cells of patients with thyroid dysfunction , 2006, Cytometry. Part B, Clinical cytometry.

[64]  J. Paul Robinson,et al.  Integrating Cytomics and Proteomics* , 2006, Molecular & Cellular Proteomics.

[65]  E. Gorjup,et al.  Three-Dimensional In Vitro Reaggregates of Embryonic Cardiomyocytes: A Potential Model System for Monitoring Effects of Bioactive Agents , 2005, Journal of biomolecular screening.

[66]  Andres Kriete,et al.  Cytomics in the realm of systems biology , 2005, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[67]  C. Contag,et al.  Ex vivo expanded dendritic cells home to T-cell zones of lymphoid organs and survive in vivo after allogeneic bone marrow transplantation. , 2005, The American journal of pathology.

[68]  E. Podniesinski,et al.  Flow cytometer in the infrared: Inexpensive modifications to a commercial instrument , 2005, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[69]  Daniel J. Muller,et al.  Measuring cell adhesion forces of primary gastrulating cells from zebrafish using atomic force microscopy , 2005, Journal of Cell Science.

[70]  A. Robitzki,et al.  Cells on a Chip - the Use of Electric Properties for Highly Sensitive Monitoring of Blood-Derived Factors Involved in Angiotensin II Type 1 Receptor Signalling , 2005, Cellular Physiology and Biochemistry.

[71]  M. Lutter,et al.  tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak , 2005, Cell Death and Differentiation.

[72]  U. Sack,et al.  Regenerative and predictive medicine of cardiovascular disease: The 9th Leipziger workshop and the 2nd international workshop on slide based cytometry , 2005, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[73]  G. Valet.  Human cytome project, cytomics, and systems biology: The incentive for new horizons in cytometry , 2005, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[74]  J. O'connor,et al.  Multiparametric characterization by flow cytometry of flow‐sorted subpopulations of a human hepatoma cell line useful for drug research , 2005, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[75]  Attila Tárnok,et al.  Scanning fluorescent microscopy analysis is applicable for absolute and relative cell frequency determinations , 2004, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[76]  U. Sack,et al.  Slide‐based cytometry and predictive medicine: The 8th Leipziger workshop and the 1st international workshop on slide‐based cytometry , 2004, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[77]  Zsolt Tulassay,et al.  Scanning fluorescent microscopy is an alternative for quantitative fluorescent cell analysis , 2004, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[78]  A Tárnok,et al.  Cytomics—New technologies: Towards a human cytome project , 2004, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[79]  Pavel Matula,et al.  Automated acquisition and processing of multidimensional image data in confocal in vivo microscopy , 2004, Microscopy research and technique.

[80]  A. Tárnok,et al.  Potential and challenges of a human cytome project. , 2004, Journal of biological regulators and homeostatic agents.

[81]  Attila Tarnok,et al.  Cytomics in predictive medicine , 2003, SPIE BiOS.

[82]  F. Powrie,et al.  Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells1 , 2003, The Journal of Immunology.

[83]  W. Göhde,et al.  Flow cytometric quantification of competitive reverse transcription-PCR products. , 2002, Clinical chemistry.

[84]  M Kozubek,et al.  Combined confocal and wide-field high-resolution cytometry of fluorescent in situ hybridization-stained cells. , 2001, Cytometry.

[85]  D. Mccormick.  Sequence the Human Genome , 1986, Bio/Technology.

[86]  P. F. Mullaney,et al.  A high efficiency flow cytometer. , 1977, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[87]  G. Valet,et al.  Cytomics and Predictive Medicine for Oncology , 2010 .

[88]  C. Poets,et al.  Diminished Phagocytosis-Induced Cell Death (PICD) in Neonatal Monocytes upon Infection with Escherichia coli , 2008, Pediatric Research.

[89]  T. Tollefsbol,et al.  Gene-environment interactions and epigenetic basis of human diseases. , 2008, Current issues in molecular biology.

[90]  Jens Friedrichs,et al.  Revealing early steps of alpha2beta1 integrin-mediated adhesion to collagen type I by using single-cell force spectroscopy. , 2007, Molecular biology of the cell.

[91]  M. Harnett.  Immunology. B cells spread and gather. , 2006, Science.

[92]  F. Emmrich,et al.  Systems biology and clinical cytomics : The 10th leipziger workshop and the 3rd international workshop on slide-based cytometry , 2006 .

[93]  Pavel Matula,et al.  Combined confocal and wide-field high-resolution cytometry ofFISH-stained cells , 2001 .