Design and synthesis of 1-(4-benzoylphenyl)imidazole derivatives as new potent 20-HETE synthase inhibitors.

[1]  Toshio Nakamura,et al.  Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. , 2004, Bioorganic & medicinal chemistry letters.

[2]  Toshio Nakamura,et al.  Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors. , 2003, Journal of medicinal chemistry.

[3]  T. Ishii,et al.  Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. , 2001, Bioorganic & medicinal chemistry letters.

[4]  N. Miyata,et al.  HET0016, a potent and selective inhibitor of 20‐HETE synthesizing enzyme , 2001, British journal of pharmacology.

[5]  A. Hudetz,et al.  Production of 20-HETE and its role in autoregulation of cerebral blood flow. , 2000, Circulation research.

[6]  J. Lasker,et al.  Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11. , 1998, The Journal of pharmacology and experimental therapeutics.

[7]  Marvin R. Rich.  Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. , 1993, Biochimica et biophysica acta.

[8]  D. Williams,et al.  Prostaglandin and fatty acid omega- and (omega-1)-oxidation in rabbit lung. Acetylenic fatty acid mechanism-based inactivators as specific inhibitors. , 1989, The Journal of biological chemistry.

[9]  P. Ortiz de Montellano,et al.  Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats. , 1994, The Journal of pharmacology and experimental therapeutics.