Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates

[1]  T. Lu,et al.  Identification of Novel Cryptic Multifunctional Antimicrobial Peptides from the Human Stomach Enabled by a Computational-Experimental Platform. , 2018, ACS synthetic biology.

[2]  M. Capurro,et al.  Peptide Design Enables Reengineering of an Inactive Wasp Venom Peptide into Synthetic Antiplasmodial Agents , 2018, ChemistrySelect.

[3]  Suzana M. Ribeiro,et al.  In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design , 2018, Nature Communications.

[4]  M. Kennedy,et al.  A mouse model study of toxicity and biodistribution of a replication defective adenovirus serotype 5 virus with its genome engineered to contain a decoy hyper binding site to sequester and suppress oncogenic HMGA1 as a new cancer treatment therapy , 2018, PloS one.

[5]  B. Nagoba,et al.  Treatment of skin and soft tissue infections caused by Pseudomonas aeruginosa—A review of our experiences with citric acid over the past 20 years , 2017 .

[6]  M. D. Torres,et al.  Antimicrobial activity of leucine‐substituted decoralin analogs with lower hemolytic activity , 2017, Journal of peptide science : an official publication of the European Peptide Society.

[7]  A. Nowak,et al.  A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice , 2017, BMC Cancer.

[8]  V. Carnovale,et al.  Relevance of multidrug-resistant Pseudomonas aeruginosa infections in cystic fibrosis. , 2017, International journal of medical microbiology : IJMM.

[9]  M. Mangoni,et al.  In vivo therapeutic efficacy of frog skin-derived peptides against Pseudomonas aeruginosa-induced pulmonary infection , 2017, Scientific Reports.

[10]  J. Fothergill,et al.  The contribution of Pseudomonas aeruginosa virulence factors and host factors in the establishment of urinary tract infections. , 2017, FEMS microbiology letters.

[11]  Octavio L. Franco,et al.  Animal venoms as antimicrobial agents , 2017, Biochemical pharmacology.

[12]  T. Lu,et al.  Next-generation precision antimicrobials: towards personalized treatment of infectious diseases. , 2017, Current opinion in microbiology.

[13]  Q. Pan,et al.  Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[14]  M. D. Torres,et al.  Novel designed VmCT1 analogs with increased antimicrobial activity. , 2017, European journal of medicinal chemistry.

[15]  M. D. Torres,et al.  Decoralin Analogs with Increased Resistance to Degradation and Lower Hemolytic Activity , 2017 .

[16]  M. Mahlapuu,et al.  Antimicrobial Peptides: An Emerging Category of Therapeutic Agents , 2016, Front. Cell. Infect. Microbiol..

[17]  Søren L Pedersen,et al.  Half‐Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation , 2016, ChemMedChem.

[18]  O. Kuipers,et al.  N-acetylgalatosamine-Mediated Regulation of the aga Operon by AgaR in Streptococcus pneumoniae , 2016, Front. Cell. Infect. Microbiol..

[19]  S. Sekaran,et al.  Transcriptome analysis of Streptococcus pneumoniae treated with the designed antimicrobial peptides, DM3 , 2016, Scientific Reports.

[20]  D. Andersson,et al.  Mechanisms and consequences of bacterial resistance to antimicrobial peptides. , 2016, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[21]  Qiumin Lu,et al.  A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. , 2016, Journal of medicinal chemistry.

[22]  Suzana M. Ribeiro,et al.  A polyalanine peptide derived from polar fish with anti-infectious activities , 2016, Scientific Reports.

[23]  Ji Hyeong Baek,et al.  Differential Properties of Venom Peptides and Proteins in Solitary vs. Social Hunting Wasps , 2016, Toxins.

[24]  D. E. Elmore,et al.  Role of arginine and lysine in the antimicrobial mechanism of histone‐derived antimicrobial peptides , 2015, FEBS letters.

[25]  R. Hoffmann,et al.  Short Proline‐Rich Antimicrobial Peptides Inhibit Either the Bacterial 70S Ribosome or the Assembly of its Large 50S Subunit , 2015, Chembiochem : a European journal of chemical biology.

[26]  Berk Hess,et al.  GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers , 2015 .

[27]  A. Middelberg,et al.  A simple and low‐cost platform technology for producing pexiganan antimicrobial peptide in E. coli , 2015, Biotechnology and bioengineering.

[28]  Hua Lu,et al.  Determination of maximum tolerated dose and toxicity of Inauhzin in mice , 2015, Toxicology reports.

[29]  R. Vitorino,et al.  Antimicrobial peptides: an alternative for innovative medicines? , 2015, Applied Microbiology and Biotechnology.

[30]  Yi Yan Yang,et al.  Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials. , 2014, Advanced drug delivery reviews.

[31]  M. Wei,et al.  Cationicity-Enhanced Analogues of the Antimicrobial Peptides, AcrAP1 and AcrAP2, from the Venom of the Scorpion, Androctonus crassicauda, Display Potent Growth Modulation Effects on Human Cancer Cell Lines , 2014, International journal of biological sciences.

[32]  S. Solomon,et al.  Antibiotic resistance threats in the United States: stepping back from the brink. , 2014, American family physician.

[33]  M. Taniguchi,et al.  Effect of substituting arginine and lysine with alanine on antimicrobial activity and the mechanism of action of a cationic dodecapeptide (CL(14‐25)), a partial sequence of cyanate lyase from rice , 2014, Biopolymers.

[34]  N. Parachin,et al.  Critical aspects to be considered prior to large-scale production of peptides. , 2013, Current protein & peptide science.

[35]  H. Vogel,et al.  Mechanism of action of puroindoline derived tryptophan-rich antimicrobial peptides. , 2013, Biochimica et biophysica acta.

[36]  D. Bamford,et al.  Clinical isolates of Pseudomonas aeruginosa from superficial skin infections have different physiological patterns. , 2013, FEMS microbiology letters.

[37]  B. Meibohm,et al.  Pharmacokinetics and Pharmacokinetic–Pharmacodynamic Correlations of Therapeutic Peptides , 2013, Clinical Pharmacokinetics.

[38]  Brendan F Gilmore,et al.  Clinical relevance of the ESKAPE pathogens , 2013, Expert review of anti-infective therapy.

[39]  Seong-Cheol Park,et al.  Antimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. , 2013, Biochimica et biophysica acta.

[40]  H. Won,et al.  Antimicrobial Peptides for Therapeutic Applications: A Review , 2012, Molecules.

[41]  V. Korolik,et al.  Inhibition of Bacterial Biofilm Formation and Swarming Motility by a Small Synthetic Cationic Peptide , 2012, Antimicrobial Agents and Chemotherapy.

[42]  G. Schneider,et al.  Designing antimicrobial peptides: form follows function , 2011, Nature Reviews Drug Discovery.

[43]  Yifeng Li.  Recombinant production of antimicrobial peptides in Escherichia coli: a review. , 2011, Protein expression and purification.

[44]  Janet L. Smith,et al.  A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway. , 2011, Journal of molecular biology.

[45]  H. Vogel,et al.  The expanding scope of antimicrobial peptide structures and their modes of action. , 2011, Trends in biotechnology.

[46]  R. Epand,et al.  Bacterial membrane lipids in the action of antimicrobial agents , 2011, Journal of peptide science : an official publication of the European Peptide Society.

[47]  M. Dryden.  Complicated skin and soft tissue infection. , 2010, The Journal of antimicrobial chemotherapy.

[48]  Wei-Jung Chen,et al.  Interaction of cationic antimicrobial peptides with phospholipid vesicles and their antibacterial activity , 2010, Peptides.

[49]  K. Lohner.  New strategies for novel antibiotics: peptides targeting bacterial cell membranes. , 2009, General physiology and biophysics.

[50]  M. N. Melo,et al.  Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations , 2009, Nature Reviews Microbiology.

[51]  Dominique Douguet,et al.  HELIQUEST: a web server to screen sequences with specific alpha-helical properties , 2008, Bioinform..

[52]  S. Lynch,et al.  Persistent infection with Pseudomonas aeruginosa in ventilator-associated pneumonia. , 2008, American journal of respiratory and critical care medicine.

[53]  B. de Kruijff,et al.  Lipid II: a central component in bacterial cell wall synthesis and a target for antibiotics. , 2008, Prostaglandins, leukotrienes, and essential fatty acids.

[54]  Manfred J. Sippl,et al.  Thirty years of environmental health research--and growing. , 1996, Nucleic Acids Res..

[55]  A. Tossi,et al.  Alpha-helical antimicrobial peptides--using a sequence template to guide structure-activity relationship studies. , 2006, Biochimica et biophysica acta.

[56]  H. Vogel,et al.  Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of action. , 2006, Biochimica et biophysica acta.

[57]  A. Rowat,et al.  Universal behavior of membranes with sterols. , 2006, Biophysical journal.

[58]  P. Balaram,et al.  Circular Dichroism of Designed Peptide Helices and β‐Hairpins: Analysis of Trp‐ and Tyr‐Rich Peptides , 2005, Chembiochem : a European journal of chemical biology.

[59]  E. Zmuda,et al.  Antimicrobial Activities and Structures of Two Linear Cationic Peptide Families with Various Amphipathic β-Sheet and α-Helical Potentials , 2005, Antimicrobial Agents and Chemotherapy.

[60]  M. Palma,et al.  Structural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista , 2005, Peptides.

[61]  Gifford Jl,et al.  Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. , 2005 .

[62]  K. Brogden.  Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? , 2005, Nature Reviews Microbiology.

[63]  M. Palma,et al.  Structural and functional characterization of N-terminally blocked peptides isolated from the venom of the social wasp Polybia paulista , 2004, Peptides.

[64]  M. Palma,et al.  Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes. , 2004, Toxicon : official journal of the International Society on Toxinology.

[65]  Joseph P Balthasar,et al.  Pharmacokinetic-pharmacodynamic modeling of methotrexate-induced toxicity in mice. , 2003, Journal of pharmaceutical sciences.

[66]  Michael R. Yeaman,et al.  Mechanisms of Antimicrobial Peptide Action and Resistance , 2003, Pharmacological Reviews.

[67]  M. Bacac,et al.  Analysis of the cytotoxicity of synthetic antimicrobial peptides on mouse leucocytes: implications for systemic use. , 2002, The Journal of antimicrobial chemotherapy.

[68]  Abraham Marmur,et al.  The mechanism of hemolysis by surfactants: effect of solution composition. , 2002, Journal of colloid and interface science.

[69]  R. Nagaraj,et al.  Host-defense antimicrobial peptides: importance of structure for activity. , 2002, Current pharmaceutical design.

[70]  Berk Hess,et al.  GROMACS 3.0: a package for molecular simulation and trajectory analysis , 2001 .

[71]  R. Epand.  Development of Novel Antimicrobial Agents: Emerging Strategies, Edited by Karl Lohner, Horizon Scientific Press, Norfolk, UK, 2001 , 2001 .

[72]  C. Walsh.  Molecular mechanisms that confer antibacterial drug resistance , 2000, Nature.

[73]  R. Hancock.  Cationic antimicrobial peptides: towards clinical applications , 2000, Expert opinion on investigational drugs.

[74]  N. Greenfield.  Applications of circular dichroism in protein and peptide analysis , 1999 .

[75]  C. Yeung,et al.  Community acquired fulminant Pseudomonas infection of the gastrointestinal tract in previously healthy infants , 1998, Journal of paediatrics and child health.

[76]  M. Buck,et al.  Trifluoroethanol and colleagues: cosolvents come of age. Recent studies with peptides and proteins , 1998, Quarterly Reviews of Biophysics.

[77]  C. Pace,et al.  A helix propensity scale based on experimental studies of peptides and proteins. , 1998, Biophysical journal.

[78]  C. B. Park,et al.  Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. , 1998, Biochemical and biophysical research communications.

[79]  C. Subbalakshmi,et al.  Mechanism of antimicrobial action of indolicidin. , 1998, FEMS microbiology letters.

[80]  R. L. Baldwin,et al.  Mechanism of helix induction by trifluoroethanol: a framework for extrapolating the helix-forming properties of peptides from trifluoroethanol/water mixtures back to water. , 1997, Biochemistry.

[81]  L Kochevar,et al.  Form Follows Function , 1997, AAOHN journal : official journal of the American Association of Occupational Health Nurses.

[82]  A. Sette,et al.  Peptide Stability in Drug Development. II. Effect of Single Amino Acid Substitution and Glycosylation on Peptide Reactivity in Human Serum , 1993, Pharmaceutical Research.

[83]  J. Thornton,et al.  PROCHECK: a program to check the stereochemical quality of protein structures , 1993 .

[84]  M. Fujino,et al.  Role of lysine residue at 7th position of wasp chemotactic peptides. , 1990, Biochemical and biophysical research communications.

[85]  S. Lifson,et al.  On the Theory of Helix—Coil Transition in Polypeptides , 1961 .

[86]  B. Zimm,et al.  Theory of the Phase Transition between Helix and Random Coil in Polypeptide Chains , 1959 .

[87]  L. Love.  The hemolysis of human erythrocytes by sodium dodecyl sulfate. , 1950, Journal of cellular and comparative physiology.

[88]  E. Yuliwati,et al.  A Review , 2019, Current Trends and Future Developments on (Bio-) Membranes.

[89]  Andaleeb Sajid,et al.  Drug Resistance in Bacteria , Fungi , Malaria , and Cancer , 2017 .

[90]  J. Bradshaw,et al.  Cationic Antimicrobial Peptides , 2012, BioDrugs.

[91]  Y. Antonenko,et al.  Indolicidin action on membrane permeability: carrier mechanism versus pore formation. , 2011, Biochimica et biophysica acta.

[92]  H. Vogel,et al.  Induction of non-lamellar lipid phases by antimicrobial peptides: a potential link to mode of action. , 2010, Chemistry and physics of lipids.

[93]  R. Epand,et al.  Lipid domains in bacterial membranes and the action of antimicrobial agents. , 2009, Biochimica et biophysica acta.

[94]  R. Hancock,et al.  Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances , 2008, Nature Protocols.

[95]  Dominique Douguet,et al.  HELIQUEST : a web server to screen sequences with specific α-helical properties , 2008 .

[96]  J. Killian,et al.  Phospholipid Structure and Escherichia Coli Membranes , 1997 .

[97]  Robert M. Sweet,et al.  Macromolecular Crystallography: Part A , 1997 .

[98]  Villegas,et al.  Stabilization of proteins by rational design of alpha-helix stability using helix/coil transition theory. , 1995, Folding & design.

[99]  D. Eisenberg.  Three-dimensional structure of membrane and surface proteins. , 1984, Annual review of biochemistry.