CNR1 Variation Modulates Risk for Drug and Alcohol Dependence

[1]  J. Gelernter,et al.  Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence , 2006, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[2]  N. Schork,et al.  Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. , 2006, American journal of human genetics.

[3]  J. Gelernter,et al.  ADH4 Gene Variation is Associated with Alcohol Dependence and Drug Dependence in European Americans: Results from HWD Tests and Case–Control Association Studies , 2006, Neuropsychopharmacology.

[4]  Joel Gelernter,et al.  Variation at APOE and STH loci and Alzheimer's disease , 2006, Behavioral and Brain Functions.

[5]  J. Gelernter,et al.  ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies , 2005, Pharmacogenetics and genomics.

[6]  G. Koob,et al.  Plasticity of reward neurocircuitry and the 'dark side' of drug addiction , 2005, Nature Neuroscience.

[7]  C. Lupica,et al.  Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction , 2005, Neuropharmacology.

[8]  Olga V. Demler,et al.  Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. , 2005, Archives of general psychiatry.

[9]  Hongyu Zhao,et al.  Practical Population Group Assignment with Selected Informative Markers: Characteristics and Properties of Bayesian Clustering via Structure , 2022 .

[10]  Mark Daly,et al.  Haploview: analysis and visualization of LD and haplotype maps , 2005, Bioinform..

[11]  Diane M. Smith,et al.  Δ9-Tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis , 1990, Psychopharmacology.

[12]  G. Uhl,et al.  Human cannabinoid receptor 1: 5′ exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse , 2004, Molecular Psychiatry.

[13]  D. Nyholt A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. , 2004, American journal of human genetics.

[14]  Peter Donnelly,et al.  A comparison of bayesian methods for haplotype reconstruction from population genotype data. , 2003, American journal of human genetics.

[15]  M. Stephens,et al.  Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. , 2003, Genetics.

[16]  Michael C Neale,et al.  Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. , 2003, The American journal of psychiatry.

[17]  C. Vadász,et al.  Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol‐induced dopamine release in the nucleus accumbens , 2003, Journal of neurochemistry.

[18]  L. Burns,et al.  Alcohol use disorders comorbid with anxiety, depression and drug use disorders. Findings from the Australian National Survey of Mental Health and Well Being. , 2002, Drug and alcohol dependence.

[19]  B. Alger Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids , 2002, Progress in Neurobiology.

[20]  Peter H. Westfall,et al.  Testing Association of Statistically Inferred Haplotypes with Discrete and Continuous Traits in Samples of Unrelated Individuals , 2002, Human Heredity.

[21]  J. Samochowiec,et al.  Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. , 2002, Drug and alcohol dependence.

[22]  J. Brotchie,et al.  Cannabinoids reduce levodopa-induced dyskinesia in Parkinson’s disease: A pilot study , 2001, Neurology.

[23]  J. Gelernter,et al.  Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence , 2001, Molecular Psychiatry.

[24]  D. Heller,et al.  The cannabinoid receptor gene (CNR1) is not affected in German i.v. drug users , 2001, Addiction biology.

[25]  M. Parmentier,et al.  Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse , 2001, Behavioural Brain Research.

[26]  T. Yamamoto,et al.  Role of cannabinoid receptor in the brain as it relates to drug reward. , 2000, Japanese journal of pharmacology.

[27]  K. Kendler,et al.  Multivariate assessment of factors influencing illicit substance use in twins from female-female pairs. , 2000, American journal of medical genetics.

[28]  P. Donnelly,et al.  Association mapping in structured populations. , 2000, American journal of human genetics.

[29]  P. Donnelly,et al.  Inference of population structure using multilocus genotype data. , 2000, Genetics.

[30]  D. Collier,et al.  No association between (AAT)n repeats in the cannabinoid receptor gene (CNR1) and heroin abuse in a Chinese population , 2000, Molecular Psychiatry.

[31]  M. Parmentier,et al.  Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB(1) receptor knockout mice. , 1999, European journal of pharmacology.

[32]  M. Bleavins,et al.  High throughput genotyping for the detection of a single nucleotide polymorphism in NAD(P)H quinone oxidoreductase (DT diaphorase) using TaqMan probes. , 1999, Molecular pathology : MP.

[33]  J. Walker,et al.  Motor actions of cannabinoids in the basal ganglia output nuclei. , 1999, Life sciences.

[34]  J. Manzanares,et al.  Pharmacological and biochemical interactions between opioids and cannabinoids. , 1999, Trends in pharmacological sciences.

[35]  L. Parsons,et al.  Dopamine activation of endogenous cannabinoid signaling in dorsal striatum , 1999, Nature Neuroscience.

[36]  M. Parmentier,et al.  Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. , 1999, Science.

[37]  K. Mackie,et al.  Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system , 1998, Neuroscience.

[38]  D. Allison,et al.  Estimating African American admixture proportions by use of population-specific alleles. , 1998, American journal of human genetics.

[39]  M. Tsuang,et al.  Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. , 1998, Archives of general psychiatry.

[40]  D. Gurwitz,et al.  Do endogenous cannabinoids contribute to HIV-mediated immune failure? , 1998, Molecular medicine today.

[41]  P. Soubrié,et al.  Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats , 1998, Psychopharmacology.

[42]  G. Chiara A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use , 1998 .

[43]  G F Koob,et al.  Drug abuse: hedonic homeostatic dysregulation. , 1997, Science.

[44]  G. Di Chiara,et al.  Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism. , 1997, Science.

[45]  D. Comings,et al.  Cannabinoid receptor gene (CNR1): association with IV drug use , 1997, Molecular Psychiatry.

[46]  G. Chiara,et al.  Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs , 1996, Nature.

[47]  John G. Cull,et al.  REWARD DEFICIENCY SYNDROME , 1996 .

[48]  N. Risch,et al.  A comparison of linkage disequilibrium measures for fine-scale mapping. , 1995, Genomics.

[49]  M. McGue,et al.  Common genetic mechanisms in alcohol, drug, and mental disorder comorbidity. , 1995, Drug and alcohol dependence.

[50]  N. Risch,et al.  Genetic analysis of idiopathic torsion dystonia in Ashkenazi Jews and their recent descent from a small founder population , 1995, Nature Genetics.

[51]  J. Crabbe,et al.  Genetic animal models of alcohol and drug abuse. , 1994, Science.

[52]  J. Vanderhaeghen,et al.  Glutamatergic regulation of cannabinoid receptor gene expression in the caudate-putamen. , 1994, European journal of pharmacology.

[53]  R. Murray,et al.  Genetics of alcohol misuse. , 1994, British medical bulletin.

[54]  F. George Genetic models in the study of alcoholism and substance abuse mechanisms , 1993, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[55]  T. Bonner,et al.  Localization of cannabinoid receptor mRNA in rat brain , 1993, The Journal of comparative neurology.

[56]  M. Herkenham,et al.  Cannabinoid Receptor Localization in Brain: Relationship to Motor and Reward Systems , 1992, Annals of the New York Academy of Sciences.

[57]  N Risch,et al.  Strong allelic association between the torsion dystonia gene (DYT1) andloci on chromosome 9q34 in Ashkenazi Jews. , 1992, American journal of human genetics.

[58]  G. Koob Drugs of abuse: anatomy, pharmacology and function of reward pathways. , 1992, Trends in pharmacological sciences.

[59]  M. Le Moal,et al.  Mesocorticolimbic dopaminergic network: functional and regulatory roles. , 1991, Physiological reviews.

[60]  D S Rae,et al.  Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. , 1990, JAMA.

[61]  M. Herkenham,et al.  The cannabinoid receptor: biochemical, anatomical and behavioral characterization , 1990, Trends in Neurosciences.

[62]  T. Bonner,et al.  Structure of a cannabinoid receptor and functional expression of the cloned cDNA , 1990, Nature.

[63]  R. Wise,et al.  Brain dopamine and reward. , 1989, Annual review of psychology.

[64]  F. Bloom,et al.  Cellular and molecular mechanisms of drug dependence. , 1988, Science.

[65]  A. Howlett,et al.  Determination and characterization of a cannabinoid receptor in rat brain. , 1988, Molecular pharmacology.

[66]  G. Thomson,et al.  Measuring the strength of associations between HLA antigens and diseases. , 1981, Tissue antigens.