Lamotrigine Serum Concentrations Throughout the Menstrual Cycle-A Study of 2 Cases

Objectives: To measure the serum concentrations of lamotrigine throughout a complete menstrual cycle. Methods: Serum concentrations of lamotrigine, estradiol, and progestogen throughout a menstrual cycle were measured in 2 young women not using hormonal contraception. Results and Conclusions: The physiological hormonal fluctuations during an ovulatory cycle were not associated with clinically relevant changes in lamotrigine serum concentrations.