Preparation of β-lactams by [2+2] cycloaddition of ketenes and imines ☆

[1]  J. Berlin,et al.  Enantioselective nucleophilic catalysis: the synthesis of aza-beta-lactams through [2+2] cycloadditions of ketenes with azo compounds. , 2008, Angewandte Chemie.

[2]  A. Arrieta,et al.  The mechanism of the ketene-imine (staudinger) reaction in its centennial: still an unsolved problem? , 2008, Accounts of chemical research.

[3]  F. Cossío,et al.  The Noncarbonylative Photochemistry of Group 6 Fischer Carbene Complexes , 2008 .

[4]  Daniel H. Paull,et al.  Bifunctional asymmetric catalysis: cooperative Lewis acid/base systems. , 2008, Accounts of chemical research.

[5]  Yanguang Wang,et al.  Selective synthesis of 4-alkylidene-beta-lactams and N,N'-diarylamidines from azides and aryloxyacetyl chlorides via a ketenimine-participating one-pot cascade process. , 2008, The Journal of organic chemistry.

[6]  Giuseppe Cremonesi,et al.  Stereoselective synthesis of 4-substituted azetidine-2,3-diones by ring opening of 1,3-thiazolidine-derived spiro-β-lactams , 2008 .

[7]  A. Slawin,et al.  N-Heterocyclic carbene catalysed beta-lactam synthesis. , 2008, Organic & biomolecular chemistry.

[8]  S. Vuković,et al.  Spiro-aziridine and bislactam formation from bisketene-imine cycloadditions. , 2008, Journal of the American Chemical Society.

[9]  T. T. Tidwell.  Hugo (Ugo) Schiff, Schiff Bases, and a Century of β‐Lactam Synthesis , 2008 .

[10]  Pan‐Lin Shao,et al.  Chiral N-heterocyclic carbene catalyzed staudinger reaction of ketenes with imines: highly enantioselective synthesis of N-Boc beta-lactams. , 2008, Organic letters.

[11]  J. E. Rode,et al.  Variation of BCP ellipticities in the course of the pericyclic and pseudopericyclic [2 + 2] cycloaddition reactions of cumulenes , 2007 .

[12]  R. Dubey,et al.  Design, Synthesis and in vitro Antibacterial Studies of Some Biologically Significant N-3-Chloro-4-[2′-hydroxy-5′-(phenylazo)phenyl]azetidin-2-ones. , 2007 .

[13]  D. Khalili,et al.  Synthesis of some mono- and bis-spiro-β-lactams of benzylisatin , 2007 .

[14]  D. Du,et al.  Diastereoselectivity in the Staudinger reaction: a useful probe for investigation of nonthermal microwave effects , 2007 .

[15]  V. Puranik,et al.  Stereoselective synthesis of spiro-β-lactams using d-(+)-glucose derived chiral pool: remarkable influence of the torquoelectronic effect , 2007 .

[16]  Kan Wang,et al.  Catalytic asymmetric [4 + 2] cycloadditions of ketenes and N-thioacyl imines: alternatives for direct mannich reactions of enolizable imines. , 2007, Journal of the American Chemical Society.

[17]  S. Sharma,et al.  A general and versatile synthesis of 3‐phenylthio β‐lactams as lead molecules for 3‐methyl‐2‐azetidinones , 2007 .

[18]  V. Ananikov,et al.  Quantum-chemical investigation of the mechanism of reaction between 1,2-dialkyldiaziridines and heterocumulenes , 2007 .

[19]  B. Alcaide,et al.  β-Lactams: Versatile Building Blocks for the Stereoselective Synthesis of Non-β-Lactam Products , 2007 .

[20]  W. Ding,et al.  Highly efficient and site-selective [3 + 2] cycloaddition of carbene-derived ambident dipoles with ketenes for a straightforward synthesis of spiro-pyrrolidones. , 2007, The Journal of organic chemistry.

[21]  L. Gentilucci,et al.  Synthesis of Four‐Membered Ring Spiro‐β‐lactams by Epoxide Ring‐Opening , 2007 .

[22]  S. Mekelleche,et al.  Elucidation of the substitutent effects on the reaction pathway of the cycloaddition of 1,3-diazabuta-1,3-dienes with ketenes using DFT-based reactivity indexes , 2007 .

[23]  Daniel H. Paull,et al.  An Asymmetric, Bifunctional Catalytic Approach to Non-Natural α-Amino Acid Derivatives , 2007 .

[24]  Daniel H. Paull,et al.  Catalytic, asymmetric inverse electron demand hetero diels-alder reactions of o-benzoquinone derivatives and ketene enolates , 2007 .

[25]  A. Arrieta,et al.  On the stereodivergent behavior observed in the Staudinger reaction between methoxyketene and (E)-N-benzylidenearyl amines. , 2007, Angewandte Chemie.

[26]  V. Puranik,et al.  Asymmetric synthesis of β-lactams by [2+2] cycloaddition using 1,4:3,6-dianhydro-d-glucitol (isosorbide) derived chiral pools , 2007 .

[27]  S. Mignani,et al.  The use of N-sulfenylimines in the β-lactam synthon method: Staudinger reaction, oxidation of the cycloadducts and ring opening of β-lactams , 2007 .

[28]  D. Tejedor,et al.  Chemo-differentiating ABB' multicomponent reactions. Privileged building blocks. , 2007, Chemical Society reviews.

[29]  M. Calter,et al.  Catalytic, asymmetric synthesis of α-phenoxy-β-aryl-β-lactams , 2007 .

[30]  P. Serda,et al.  Staudinger Reaction of Schiff Bases of Acetylthiophene and Acetylpyridine with Ketenes. Diastereoselective Synthesis of 4-Heterosubstituted β-Lactams and their Conversion to β-Thiolactams , 2007 .

[31]  D. Du,et al.  Notable and obvious ketene substituent-dependent effect of temperature on the stereoselectivity in the Staudinger reaction. , 2007, The Journal of organic chemistry.

[32]  A. Konev,et al.  A simple route to side-chain fluorinated \beta -lactams from ring-fluorinated aziridines , 2007 .

[33]  S. Kawaguchi,et al.  Highly selective double chalcogenation of isocyanides with disulfide-diselenide mixed systems. , 2007, The Journal of organic chemistry.

[34]  Z. G. Aliev,et al.  Five-membered 2,3-dioxo heterocycles: LII. Reactions of 5-aryl-4-(quinoxalin-2-yl)-2,3-dihydrofuran-2,3-diones with Schiff bases and dicyclohexylcarbodiimide. Crystalline and molecular structure of substituted 2-(4-oxo-3,4-dihydro-2H1,3-oxazin-5-yl)quinoxalines , 2007 .

[35]  László Kürti,et al.  Molecules and Medicine , 2007 .

[36]  C. Ahn,et al.  The Formation of Spiro-β-lactams and Amides from Reaction of Cyclic Ketenes with Imines , 2007 .

[37]  A. Viso,et al.  Highly diastereoselective Staudinger reaction on 5,6-dihydropyrazin-2-(1H)-ones. Synthesis of enantiopure fused oxopiperazino-β-lactams , 2006 .

[38]  R. Raghunathan,et al.  Stereoselective synthesis of bis-β-lactam grafted macrocycles , 2006 .

[39]  M. P. Mahajan,et al.  Tandem [2+2] cycloaddition and Cope rearrangement in reactions of cross-conjugated azatrienes with conjugated ketenes: a facile single step synthesis of novel azocinone derivatives , 2006 .

[40]  T. Lectka,et al.  Catalytic, asymmetric synthesis of 1,4-benzoxazinones: a remarkably enantioselective route to alpha-amino acid derivatives from o-benzoquinone imides. , 2006, Angewandte Chemie.

[41]  M. Gómez-Gallego,et al.  Synthesis of highly functionalized macrocycles by the peripheral functionalization of macrocyclic diimines. , 2006, The Journal of organic chemistry.

[42]  C. del Pozo,et al.  Synthesis of enantiopure pyrrolidine-derived peptidomimetics and oligo-beta-peptides via nucleophilic ring-opening of beta-lactams. , 2006, The Journal of organic chemistry.

[43]  Daniel H. Paull,et al.  Catalytic, enantioselective bifunctional inverse electron demand hetero-Diels-Alder reactions of ketene enolates and o-benzoquinone diimides. , 2006, Journal of the American Chemical Society.

[44]  S. Testero,et al.  Synthesis of 3-(aryl)alkenyl-beta-lactams by an efficient application of olefin cross-metathesis on solid support. , 2006, Organic letters.

[45]  D. Du,et al.  Do reaction conditions affect the stereoselectivity in the Staudinger reaction? , 2006, The Journal of organic chemistry.

[46]  B. Arndtsen,et al.  Direct, palladium-catalyzed, multicomponent synthesis of beta-lactams from imines, acid chloride, and carbon monoxide. , 2006, Organic letters.

[47]  N. de Kimpe,et al.  Asymmetric synthesis of 1-(2- and 3-haloalkyl)azetidin-2-ones as precursors for novel piperazine, morpholine, and 1,4-diazepane annulated beta-lactams. , 2006, The Journal of organic chemistry.

[48]  Raluca M. Fratila,et al.  Functionalization of N-[(silyl)methyl]-beta-lactam carbanions with carbon electrophiles. , 2006, The Journal of organic chemistry.

[49]  M. Nahmany,et al.  Simple Approach to β-Lactam Derivatives from N-Acylimidazoles , 2006 .

[50]  Yong Liang,et al.  Origin of the relative stereoselectivity of the beta-lactam formation in the Staudinger reaction. , 2006, Journal of the American Chemical Society.

[51]  Xichen Lin,et al.  Explorations on the total synthesis of the unusual marine alkaloid chartelline A. , 2006, The Journal of organic chemistry.

[52]  J. E. Rode,et al.  An ab initio study on the allene-isocyanic acid and ketene-vinylimine [2 + 2] cycloaddition reaction paths. , 2006, The journal of physical chemistry. A.

[53]  T. Tidwell.  Ketene chemistry after 100 years : Ready for a new century , 2006 .

[54]  Yong Liang,et al.  A Versatile Method for the Synthesis of 3-Alkoxycarbonyl β-Lactam Derivatives , 2006 .

[55]  T. Tsuno,et al.  Cycloaddition reaction of schiff bases with ketenes generated by pyrolysis of 2‐aryl‐substituted 1,5,7‐trioxaspiro[2.5]octane‐4,8‐diones , 2006 .

[56]  P. Campomanes,et al.  Mechanism of cycloaddition reactions between ketene and N-silyl-, N-germyl-, and N-stannylimines: a theoretical investigation. , 2005, The journal of physical chemistry. A.

[57]  J. Robertson,et al.  On the reaction of diphenylketene with isocyanides. , 2005, Organic & biomolecular chemistry.

[58]  A. Forni,et al.  Asymmetric synthesis of 1,3-thiazolidine-derived spiro-β-lactams via a Staudinger reaction between chiral ketenes and imines , 2005 .

[59]  E. Corey,et al.  Proteasome inhibition by a totally synthetic beta-lactam related to salinosporamide A and omuralide. , 2005, Journal of the American Chemical Society.

[60]  N. Kimpe,et al.  Electrophile-Induced Ring Expansions ofβ-Lactams toward γ-Lactams , 2005 .

[61]  T. Tidwell.  The first century of ketenes (1905-2005): the birth of a versatile family of reactive intermediates. , 2005, Angewandte Chemie.

[62]  M. Ruiz,et al.  Synthesis of fused or not β-lactam-biaryl hybrids by free radical aryl–aryl coupling of 2-azetidinone-tethered haloarenes , 2005 .

[63]  Elaine C. Lee,et al.  Catalytic asymmetric Staudinger reactions to form beta-lactams: an unanticipated dependence of diastereoselectivity on the choice of the nitrogen substituent. , 2005, Journal of the American Chemical Society.

[64]  T. Lectka,et al.  An anionic nucleophilic catalyst system for the diastereoselective synthesis of trans-beta-lactams. , 2005, Organic letters.

[65]  P. Campomanes,et al.  The formation of silylated β-lactams from silylketenes through lewis acid promoted [2+2] cycloaddition : A combined theoretical and experimental study , 2005 .

[66]  L. Gentilucci,et al.  Highly Regio‐ and Diastereoselective Palladium‐Catalyzed Allylic Substitution. Synthesis of 3‐(2‐Aminobutylidene)‐ 4‐arylazetidin‐2‐ones , 2005 .

[67]  L. Gentilucci,et al.  Introduction of hydroxyl- or keto- functionalities in azetidin-2-ones side chain via allylic bromide rearrangement, followed by supported reagent substitution , 2005 .

[68]  K. Lyssenko,et al.  Reaction of 1,2-dialkyldiaziridines with ketenes as a new approach to cyclic and linear systems containing the N— C—N fragment , 2005 .

[69]  N. Kimpe,et al.  Diastereoselective ring expansion of beta-lactams toward gamma-lactams via N-acyliminium intermediates. , 2005 .

[70]  V. Puranik,et al.  Synthesis of cis bis-β-lactams via Staudinger cycloaddition reaction using C2-symmetric 1,2-diamines , 2005 .

[71]  L. Gentilucci,et al.  Highly diastereoselective allylic azide formation and isomerization. Synthesis of 3(2'-amino)-beta-lactams. , 2005, Organic letters.

[72]  Yong Liang,et al.  Microwave- and photoirradiation-induced staudinger reactions of cyclic imines and ketenes generated from alpha-diazoketones. A further investigation into the stereochemical process. , 2005, The Journal of organic chemistry.

[73]  T. Lectka,et al.  Bifunctional Lewis acid-nucleophile-based asymmetric catalysis: mechanistic evidence for imine activation working in tandem with chiral enolate formation in the synthesis of beta-lactams. , 2005, Journal of the American Chemical Society.

[74]  N. Makhova,et al.  An unexpected transformation of 1,2-dialkyldiaziridines into N-{[acetyl(alkyl)amino]methyl}-N-(alken-1-yl)acetamide under the action of the parent ketene , 2005 .

[75]  Kevin Brown.  Penicillin Man: Alexander Fleming and the Antibiotic Revolution , 2004 .

[76]  C. del Pozo,et al.  Diastereoselective [2+2]-cycloaddition reactions of unsymmetrical cyclic ketenes with imines: synthesis of modified prolines and theoretical study of the reaction mechanism. , 2004, The Journal of organic chemistry.

[77]  T. Webb,et al.  Novel Asymmetric Approach to Proline-Derived Spiro-β-lactams , 2004 .

[78]  Elena Díez,et al.  Asymmetric synthesis of trans-3-amino-4-alkylazetidin-2-ones from chiral N,N-dialkylhydrazones. , 2004, Organic letters.

[79]  J. Aizpurua,et al.  Asymmetric Synthesis of β-Lactams Through the Staudinger Reaction and Their Use as Building Blocks of Natural and Nonnatural Products , 2004 .

[80]  L. Gentilucci,et al.  Practical synthesis of 3-bromo-5,6-dihydropyridin-2-ones via β,γ-unsaturated α-bromo-ketene/imine cycloaddition , 2004 .

[81]  T. Lectka,et al.  Advances in the Catalytic, Asymmetric Synthesis of β-Lactams , 2004 .

[82]  G. C. Fu.  Asymmetric catalysis with "planar-chiral" derivatives of 4-(dimethylamino)pyridine. , 2004, Accounts of chemical research.

[83]  A. Papagni,et al.  Stereoselective synthesis of 3-amino-4-substituted-2-azetidinones via [2+2] cycloadditions of tricarbonyl(η6arene)chromium(0)complexed imines , 2003 .

[84]  K. Lyssenko,et al.  A new direction of ring expansion of 1,2-dialkyldiaziridines in the reactions with arylketenes , 2003 .

[85]  G. S. Singh.  Recent Progress in the Synthesis and Chemistry of Azetidinones , 2003 .

[86]  A. R. Far.  Ketenes in polymer-assisted synthesis. , 2003 .

[87]  S. García‐Granda,et al.  Synthesis of beta-lactams from a N-rhenaimine: effect of the transition metal on the energetic profile of the Staudinger reaction. , 2003, Journal of the American Chemical Society.

[88]  V. Puranik,et al.  Asymmetric synthesis of azetidin-2-ones by [2+2] cycloaddition using chiral imines derived from D-(+)-glucose , 2003 .

[89]  V. Puranik,et al.  Ephedrine derived reusable chiral auxiliary for the synthesis of optically pure 3-hydroxy-4-aryl-β-lactams , 2003 .

[90]  B. Arndtsen,et al.  The development of a catalytic synthesis of münchnones: a simple four-component coupling approach to alpha-amino acid derivatives. , 2003, Journal of the American Chemical Society.

[91]  A. Venturini,et al.  A CASPT2 and CASSCF approach to the cycloaddition of ketene and imine: a new mechanistic scheme of the Staudinger reaction. , 2002, The Journal of organic chemistry.

[92]  T. Lectka,et al.  The development of the first catalyzed reaction of ketenes and imines: catalytic, asymmetric synthesis of beta-lactams. , 2002, Journal of the American Chemical Society.

[93]  R. Fernández,et al.  N,N-dialkylhydrazones as the imine component in the Staudinger-like [2+2] cycloaddition to benzyloxyketene. , 2002, Angewandte Chemie.

[94]  C. Pozo,et al.  Staudinger reactions of unsymmetrical cyclic ketenes: a synthetically useful approach to spiro β-lactams and derivatives. Reaction mechanism and theoretical studiesElectronic supplementary information (ESI) available: Spectral data for compounds 4b–4m and 5b–5d and Cartesian coordinates and energies , 2002 .

[95]  G. C. Fu,et al.  Enantioselective Staudinger synthesis of beta-lactams catalyzed by a planar-chiral nucleophile. , 2002, Journal of the American Chemical Society.

[96]  M. Gómez-Gallego,et al.  Synthesis of ferrocene-substituted 2-azetidinones. , 2001, The Journal of organic chemistry.

[97]  T. Lectka,et al.  Asymmetric catalysis on sequentially-linked columns. , 2001, Journal of the American Chemical Society.

[98]  G. Abbiati,et al.  [2+2] Cycloaddition Reactions of 1-Benzyl-2,4-Diphenyl-1,3-Diazabuta-1,3-Diene with Chiral Ketenes , 2001 .

[99]  Xichen Lin,et al.  Model studies on total synthesis of the chartellines, spirocyclic β-lactam alkaloids from a marine bryozoan , 2001 .

[100]  C. Femoni,et al.  One Pot Synthesis of New β-Lactams Containing the Ferrocene Moiety , 2001 .

[101]  Sooin Park,et al.  An efficient and eco-friendly approach to N-15-unsubstituted beta-lactams: N-15-labled synthons for taxol and its analogs , 2001 .

[102]  L. Hegedus,et al.  Synthesis and complexation properties of poly(ethylene glycol)-linked mono- and bis-dioxocyclams. , 2000, The Journal of organic chemistry.

[103]  A. Arrieta,et al.  New insights on the origins of the stereocontrol of the staudinger reaction: [2 + 2] cycloaddition between ketenes and N-silylimines. , 2000, The Journal of organic chemistry.

[104]  A. Arrieta,et al.  A Theoretical−Experimental Approach to the Mechanism of the Photocarbonylation of Chromium(0) (Fischer)−Carbene Complexes and Their Reaction with Imines , 2000 .

[105]  V. Puranik,et al.  Stereoselective Synthesis of cis-Bis-β-lactams Linked with an Ethylene Bridge , 2000 .

[106]  F. Becker,et al.  Unprecedented stereoselectivity in the Staudinger reaction with polycyclic aromatic imines , 2000 .

[107]  T. Lectka,et al.  Catalytic, Asymmetric Synthesis of β-Lactams , 2000 .

[108]  M. Chmielewski,et al.  Strategies for the Formation of 1-Dethia-1-oxa-cephams , 2000 .

[109]  Marvin J Miller.  Recent Aspects of the Chemistry of β-Lactams—II , 2000 .

[110]  E. Bandini,et al.  Stereochemical Aspects of a Two‐Step Staudinger Reaction − Asymmetric Synthesis of Chiral Azetidine‐2‐ones , 2000 .

[111]  R. Santillán,et al.  Preparation of N-aryl-substituted spiro-β-lactams via Staudinger cycloaddition , 1999 .

[112]  J. Aizpurua,et al.  Asymmetric Synthesis of β‐Lactams by Staudinger Ketene‐Imine Cycloaddition Reaction , 1999 .

[113]  Paola Vicennati,et al.  Reversal of stereochemistry in a two-step Staudinger reaction by changing the backbone protecting group. Synthesis of NH-trans-3-benzoyloxy-4-aryl-azetidinones , 1999 .

[114]  T. Lectka,et al.  Nucleophilic metal complexes as acylation catalysts: solvent-dependent "switch" mechanisms leading to the first catalyzed Staudinger reaction. , 1999, Organic letters.

[115]  L. Hegedus,et al.  Synthesis of Carbon-Linked Bis(chromium carbene) Complexes, Bis(azapenams), and Bis(dioxotetraazacyclotetradecadienes) , 1999 .

[116]  I. Okamoto,et al.  Hetero [4 + 2] cycloadditions of (trialkylsilyl)vinylketenes. Synthesis of alpha,beta-unsaturated delta-valerolactones and -lactams. , 1999, Organic letters.

[117]  S. Minakata,et al.  NOVEL SYNTHESIS OF DIAZETIDINE-2,4-DIONE BY RING EXPANSION OF DIAZIRIDINONE , 1999 .

[118]  T. Endo,et al.  A novel reactive polymer having 2-azetidinone-structure on the main chain : Development of its convenient synthetic method based on [2 + 2]cycloaddition of bisketene with bisimine , 1998 .

[119]  M. Panunzio,et al.  Microwave-assisted solvent-free organic reactions: Synthesis of β-lactams from 1,3-azadienes , 1998 .

[120]  A. Arrieta,et al.  Origins of the Stereodivergent Outcome in the Staudinger Reaction between Acyl Chlorides and Imines. , 1998, The Journal of organic chemistry.

[121]  L. Hegedus,et al.  Synthesis of Optically Active Imidazolines, Azapenams, Dioxocyclams, and Bis-dioxocyclams , 1997 .

[122]  A. Linden,et al.  Construction of Quaternary Stereogenic Centers via [2 + 2] Cycloaddition Reactions. Synthesis of Homochiral 4,4-Disubstituted 2-Azetidinones and Imine Substituent Effects on beta-Lactam Formation. , 1997, The Journal of organic chemistry.

[123]  Á. Monge,et al.  C4,C4-Bis--lactam to Fused Bis-?-lactam Rearrangement , 1996 .

[124]  V. Puranik,et al.  Stereoselective synthesis of homochiral pyrrolidinones and cis, cis-bis-β-lactams from (+)-(1S,2S)-2-amino-1-phenylpropan-1,3-diol , 1996 .

[125]  E. Gordon,et al.  Solid-Supported Combinatorial Synthesis of Structurally Diverse β-Lactams , 1996 .

[126]  Alan R. Katritzky,et al.  Comprehensive Heterocyclic Chemistry IV , 1996 .

[127]  I. Ojima.  Recent Advances in the .beta.-Lactam Synthon Method , 1995 .

[128]  L. Hegedus,et al.  Synthesis and Metal Complexation Reactions of Bis-Dioxocyclams from Photochemical Reaction of Bis-Chromium Alkoxycarbene Complexes with Imidazolines , 1995 .

[129]  X. Assfeld,et al.  Comments on “Ab initio studies on the mechanism of the cycloaddition reaction of fluoroketene with imines: substituent effects (Z. Xu, D. Fang and X. Fu, J. Mol. Struct. (Theochem), 305 (1994) 191)” , 1995 .

[130]  Zhenfeng Xu,et al.  Ab initio studies on the mechanism of the cycloaddition reaction of fluoroketene with imines: substituent effects , 1994 .

[131]  M. Jayaraman,et al.  Efficient Asymmetric Synthesis of cis-4-Formyl .beta.-Lactams from L-(+)-Tartaric Acid , 1994 .

[132]  T. Sordo,et al.  Torquoelectronic effect in the control of the stereoselectivity of ketene-imine cycloaddition reactions , 1993 .

[133]  G. Georg,et al.  Recent advances in the chemistry and biology of -lactams and -lactam antibiotics , 1993 .

[134]  X. López,et al.  A semiempirical theoretical study on the formation of .beta.-lactams from ketenes and imines , 1993 .

[135]  Y. Osamura,et al.  Dual one-centre frontier-orbital interactions in [2 + 2] cycloadditions of ketenes , 1993 .

[136]  G. Georg,et al.  The Organic chemistry of β-lactams , 1993 .

[137]  J. Rodríguez‐López,et al.  Stereoselective preparation of mono- and bis-.beta.-lactams by the 1,4-diaza-1,3-diene - acid chloride condensation: scope and synthetic applications , 1992 .

[138]  D. Fang,et al.  Ab initio study on the mechanism of cycloaddition reaction of ketene with methylenimine : a new reaction scheme , 1992 .

[139]  T. Sordo,et al.  An ab initio study on the mechanism of the ketene-imine cycloaddition reaction , 1992 .

[140]  G. Koten,et al.  Syntheses of 3-amino-2-azetidinones: A literature survey , 1991 .

[141]  M. Yamashita,et al.  Azetidines and bisazetidines. Their synthesis and use as the key intermediates to enantiomerically pure diamines, amino alcohols, and polyamines , 1991 .

[142]  D. Shelly,et al.  Diastereoselective synthesis of bis-beta-lactams , 1991 .

[143]  U. Schubert,et al.  XII. Synthese kleiner organischer Ringsysteme aus alkoxyoder alkylthio-substituierten Silylcarben-Komplexen (CO)5MC(XEt)SiR3 (M = Cr, Mo, W; X = O, S) und davon abgeleiteten ketenen R3Si(EtX) CCO☆ , 1989 .

[144]  R. Volante,et al.  Mechanism of an acid chloride-imine reaction by low-temperature FT-IR: .beta.-lactam formation occurs exclusively through a ketene intermediate , 1989 .

[145]  I. Ojima,et al.  Remarkable effects of lone pair-lone pair interactions on the extremely stereoselective [2 + 2] cycloaddition of azidoketene to chiral 3-imino-.beta.-lactams , 1987 .

[146]  G. Hughes,et al.  Cycloadditions of cyanoketenes to cinnamylidenamines and benzylidenamines. Synthetic scope, stereochemistry, and mechanism , 1985 .

[147]  Davidr . Evans,et al.  The asymmetric synthesis of β-lactam antibiotics - I. application of chiral oxazolidones in the staudinger reaction. , 1985 .

[148]  Davidr . Evans,et al.  The asymmetric synthesis of β-lactam antibiotics -II. The first enantioselective synthesis of the carbacephalosporin nucleus. , 1985 .

[149]  M. Weigele,et al.  A comparison of the antibacterial and β-lactamase inhibiting properties of penam and (2,3)-β-methylenepenam derivatives : The discovery of a new β-lactamase inhibitor. Conformational requirements for penicillin antibacterial activity , 1983 .

[150]  John C. Sheehan,et al.  The Enchanted Ring: The Untold Story of Penicillin , 1986 .

[151]  J. Chang,et al.  The observation of zwitterions in the thermal reaction of ketenes with carbon-nitrogen double bonds , 1982 .

[152]  J. Cornforth,et al.  Robert Burns Woodward, 10 April 1917 - 8 July 1979 , 1981, Biographical Memoirs of Fellows of the Royal Society.

[153]  I. Ojima,et al.  Effective method for the asymmetric synthesis of bis-β-lactams by the cycloaddition of azidoketen to benzylideneamines bearing a chiral β-lactam backbone , 1981 .

[154]  D. Seyferth.  Houben-Weyl methoden der organischen chemie , 1978 .

[155]  H. W. Moore,et al.  Cyanoketenes. Mechanism of cycloaddition of chlorocyanoketene to imidates , 1978 .

[156]  J. Gleason,et al.  Nuclear analogues of beta-lactam antibiotics. I. the total synthesis of a 7-oxo-1,3-diazabicyclo[3.2.0]heptane-2-carboxylic acid via a versatile monocyclic beta-lactam intermediate. , 1977, Journal of the American Chemical Society.

[157]  R. Hall,et al.  Nuclear analogues of beta-lactam antibiotics. 2 The total synthesis of 8-oxo-4-thia-z-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acids. , 1977, Journal of the American Chemical Society.

[158]  R. Owens,et al.  Halogenated ketenes. XXX. Trimethylsilylbromoketene , 1976 .

[159]  M. Komatsu,et al.  Reaction of diaziridines with diphenylketene and isocyanates , 1974 .

[160]  R. Srivastava,et al.  Syntheses of ß-Lactams , 1973 .

[161]  H. Zimmerman.  Moebius-Hueckel concept in organic chemistry. Application of organic molecules and reactions , 1971 .

[162]  A. Bose,et al.  Studies on lactams. Part XVI. Stereochemistry of β-lactam formation☆ , 1971 .

[163]  R. Kerber,et al.  The mechanism of cycloaddition of diphenylketene with azo compounds , 1974 .

[164]  Henri B. Kagan,et al.  Cycloaddition des cetenes sur les imines (II) mise en evidence d′un intermediaire de reaction au cours de l'addition diphenylcetene - benzalaniline , 1968 .

[165]  Roald Hoffmann,et al.  Conservation of orbital symmetry , 1968 .

[166]  W. T. Brady,et al.  Kinetics and mechanism of the cycloaddition of diphenylketene and dihydropyran , 1967 .

[167]  H. Ulrich.  Cycloaddition reactions of heterocumulenes , 1967 .

[168]  J. Hamer,et al.  1,2-cycloaddition reactions : the formation of three- and four- membered heterocycles , 1967 .

[169]  R. Woodward,et al.  The Total Synthesis of Cephalosporin C1 , 1966 .

[170]  R. Hoffmann.  Selection Rules for Concerted Cycloaddition Reactions (福井謙一とフロンティア軌導理論) -- (参考論文) , 1965 .

[171]  R. Huisgen,et al.  Stereospecific Addition of Ketenes onto Enol Ethers , 1964 .

[172]  I. Ugi,et al.  Isonitrile, VI. Umsetzungen von Isonitrilen mit Ketenen , 1961 .

[173]  J. C. Sheehan,et al.  THE TOTAL SYNTHESIS OF PENICILLIN V , 1957 .

[174]  L. Horner,et al.  Über Lichtreaktionen VI: Addukte aus Azoverbindungen und Ketenen , 1956 .

[175]  E. Abraham,et al.  Cephalosporin C, a New Antibiotic containing Sulphur and D-α-Aminoadipic Acid , 1955, Nature.

[176]  E. Abraham,et al.  Isolation of antibiotics from a species of Cephalosporium; cephalosporins P1, P2, P3, P4, and P5. , 1951, The Biochemical journal.

[177]  E. Corey,et al.  THE TOTAL SYNTHESIS OF A 5-PHENYL PENICILLIN: METHYL 5-PHENYL-(2-CARBOMETHOXYETHYL)-PENICILLINATE , 1950 .

[178]  H. Clarke.  The chemistry of penicillin , 1949 .

[179]  A. H. Cook,et al.  40. cis-Azo-compounds. Part IV. Some reactions with diphenylketen , 1941 .

[180]  C. Ingold,et al.  LIX.—The additive formation of four-membered rings. Part VI. The addition of azo-compounds to ethylenes and some transformations of the dimethylene-1 : 2-di-imine ring , 1925 .

[181]  H. Staudinger.  Zur Kenntniss der Ketene. Diphenylketen , 1907 .

[182]  H. Staudinger.  Über Ketene. 4. Mitteilung: Reaktionen des Diphenylketens , 1907 .

[183]  H. Schiff.  Mittheilungen aus dem Universitätslaboratorium in Pisa: Eine neue Reihe organischer Basen , 1864 .