Magnetic Resonance Microscopy in Basic Studies of Brain Structure and Function a , b

The inventors of magnetic resonance imaging (MRI) realized at the outset that the technology was scalable to the microscopic domain.lJ In its 20-year history, MRI has become an extraordinarily successful tool in the clinical arena, with research focused on human studies where resolution at 1 mm is generally adequate. A small community of researchers has pursued the extension of MRI to magnetic resonance microscopy (MRM).3,4 This paper will focus on ( a ) a definition of MRM; (b) a discussion of the essential technologies required for MRM; and (c) two specific applications of MRM in the study of brain structure and function.

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