Statement on imaging and pulmonary hypertension from the Pulmonary Vascular Research Institute (PVRI)

Pulmonary hypertension (PH) is highly heterogeneous and despite treatment advances it remains a life-shortening condition. There have been significant advances in imaging technologies, but despite evidence of their potential clinical utility, practice remains variable, dependent in part on imaging availability and expertise. This statement summarizes current and emerging imaging modalities and their potential role in the diagnosis and assessment of suspected PH. It also includes a review of commonly encountered clinical and radiological scenarios, and imaging and modeling-based biomarkers. An expert panel was formed including clinicians, radiologists, imaging scientists, and computational modelers. Section editors generated a series of summary statements based on a review of the literature and professional experience and, following consensus review, a diagnostic algorithm and 55 statements were agreed. The diagnostic algorithm and summary statements emphasize the key role and added value of imaging in the diagnosis and assessment of PH and highlight areas requiring further research.

[1]  W. Seeger,et al.  Right ventricular dyssynchrony: from load-independent right ventricular function to wall stress in severe pulmonary arterial hypertension , 2020, Pulmonary circulation.

[2]  Robert A. Lewis,et al.  Identification of Cardiac Magnetic Resonance Imaging Thresholds for Risk Stratification in Pulmonary Arterial Hypertension , 2020, American journal of respiratory and critical care medicine.

[3]  W. Seeger,et al.  Association of right atrial conduit phase with right ventricular lusitropic function in pulmonary hypertension , 2020, The International Journal of Cardiovascular Imaging.

[4]  M. Humbert,et al.  Screening strategies for pulmonary arterial hypertension , 2019, European heart journal supplements : journal of the European Society of Cardiology.

[5]  S. Adusumalli,et al.  Pulmonary Hypertension in Heart Failure Patients , 2019, Cardiac failure review.

[6]  A. Barker,et al.  Proximal pulmonary vascular stiffness as a prognostic factor in children with pulmonary arterial hypertension , 2019, European heart journal cardiovascular Imaging.

[7]  D. Ivy,et al.  Paediatric pulmonary arterial hypertension: updates on definition, classification, diagnostics and management , 2019, European Respiratory Journal.

[8]  M. Graves,et al.  Diagnostic and prognostic significance of cardiovascular magnetic resonance native myocardial T1 mapping in patients with pulmonary hypertension , 2018, Journal of Cardiovascular Magnetic Resonance.

[9]  F. McGowan,et al.  Early Right Ventricular Systolic Dysfunction and Pulmonary Hypertension Are Associated With Worse Outcomes in Pediatric Acute Respiratory Distress Syndrome , 2018, Critical care medicine.

[10]  J. Wild,et al.  Diagnosis of Pulmonary Hypertension with Cardiac MRI: Derivation and Validation of Regression Models , 2018, Radiology.

[11]  M. Humbert,et al.  Pulmonary Vascular Involvement in Chronic Obstructive Pulmonary Disease. Is There a Pulmonary Vascular Phenotype? , 2018, American journal of respiratory and critical care medicine.

[12]  F. Wacker,et al.  Cardio-pulmonary MRI for detection of treatment response after a single BPA treatment session in CTEPH patients , 2018, European Radiology.

[13]  A. Barker,et al.  Noninvasive wave intensity analysis predicts functional worsening in children with pulmonary arterial hypertension. , 2018, American journal of physiology. Heart and circulatory physiology.

[14]  D. Ivy,et al.  3D echocardiographic evaluation of right ventricular function and strain: a prognostic study in paediatric pulmonary hypertension , 2018, European heart journal cardiovascular Imaging.

[15]  T. Derlin,et al.  Advanced imaging in pulmonary hypertension: emerging techniques and applications , 2018, The International Journal of Cardiovascular Imaging.

[16]  Jeroen J. Bax,et al.  Prognostic Value of Right Ventricular Strain Using Speckle-Tracking Echocardiography in Pulmonary Hypertension: A Systematic Review and Meta-analysis. , 2018, The Canadian journal of cardiology.

[17]  J. Wild,et al.  The impact of patient choice on survival in chronic thromboembolic pulmonary hypertension , 2018, European Respiratory Journal.

[18]  J. Wild,et al.  Identifying At-Risk Patients with Combined Pre- and Postcapillary Pulmonary Hypertension Using Interventricular Septal Angle at Cardiac MRI , 2018, Radiology.

[19]  S. Ghio,et al.  Strengths and weaknesses of echocardiography for the diagnosis of pulmonary hypertension. , 2018, International journal of cardiology.

[20]  K. Collins,et al.  Effect of electrical dyssynchrony on left and right ventricular mechanics in children with pulmonary arterial hypertension. , 2018, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[21]  J. Kasprzak,et al.  Imaging the Right Heart-Pulmonary Circulation Unit: The Role of Ultrasound. , 2018, Heart failure clinics.

[22]  Jürgen Biederer,et al.  Magnetic resonance angiography for the primary diagnosis of pulmonary embolism: A review from the international workshop for pulmonary functional imaging , 2018, World journal of radiology.

[23]  J. Wild,et al.  Pulmonary Artery Size in Interstitial Lung Disease and Pulmonary Hypertension: Association with Interstitial Lung Disease Severity and Diagnostic Utility , 2018, Front. Cardiovasc. Med..

[24]  A. Swift,et al.  CT derived left atrial size identifies left heart disease in suspected pulmonary hypertension: Derivation and validation of predictive thresholds , 2018, International journal of cardiology.

[25]  J. Remy,et al.  Dual-energy CT (DECT) lung perfusion in pulmonary hypertension: concordance rate with V/Q scintigraphy in diagnosing chronic thromboembolic pulmonary hypertension (CTEPH) , 2018, European Radiology.

[26]  D. O’Regan,et al.  Exercise cardiac MRI unmasks right ventricular dysfunction in acute hypoxia and chronic pulmonary arterial hypertension , 2018, American journal of physiology. Heart and circulatory physiology.

[27]  Raúl San José Estépar,et al.  Pulmonary Artery–Vein Classification in CT Images Using Deep Learning , 2018, IEEE Transactions on Medical Imaging.

[28]  F. Wacker,et al.  Feasibility of quantitative regional ventilation and perfusion mapping with phase‐resolved functional lung (PREFUL) MRI in healthy volunteers and COPD, CTEPH, and CF patients , 2018, Magnetic resonance in medicine.

[29]  O. Elci,et al.  Right ventricular function mirrors clinical improvement with use of prostacyclin analogues in pediatric pulmonary hypertension , 2018, Pulmonary circulation.

[30]  S. Wolff,et al.  Use of Cardiac Magnetic Resonance Imaging in Assessing Mitral Regurgitation: Current Evidence. , 2018, Journal of the American College of Cardiology.

[31]  M. B. Bacchi Reggiani,et al.  Pulmonary hypertension due to left heart disease: analysis of survival according to the haemodynamic classification of the 2015 ESC/ERS guidelines and insights for future changes , 2018, European journal of heart failure.

[32]  J. Roos‐Hesselink,et al.  Pulmonary arterial stiffness indices assessed by intravascular ultrasound in children with early pulmonary vascular disease: prediction of advanced disease and mortality during 20-year follow-up , 2018, European heart journal cardiovascular Imaging.

[33]  K. Hunter,et al.  Measuring Flow Hemodynamic Indices and Oxygen Consumption in Children with Pulmonary Hypertension: A Comparison of Catheterization and Phase-Contrast MRI , 2018, Pediatric Cardiology.

[34]  G. S. Gulsin,et al.  Cardiovascular magnetic resonance in the evaluation of heart valve disease , 2017, BMC Medical Imaging.

[35]  D. Ivy,et al.  Right Atrial Deformation in Predicting Outcomes in Pediatric Pulmonary Hypertension , 2017, Circulation. Cardiovascular imaging.

[36]  Fengyuan Hu,et al.  Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension , 2017, Circulation.

[37]  J. Wild,et al.  Non-invasive methods for estimating mPAP in COPD using cardiovascular magnetic resonance imaging , 2017, European Radiology.

[38]  Ami A. Shah,et al.  Right ventricular longitudinal strain is diminished in systemic sclerosis compared with idiopathic pulmonary arterial hypertension , 2017, European Respiratory Journal.

[39]  S. Colan,et al.  Relationship of Echocardiographic Z Scores Adjusted for Body Surface Area to Age, Sex, Race, and Ethnicity: The Pediatric Heart Network Normal Echocardiogram Database , 2017, Circulation. Cardiovascular imaging.

[40]  T. Crowe,et al.  Non-invasive imaging of global and regional cardiac function in pulmonary hypertension , 2017, Pulmonary circulation.

[41]  I. Lang,et al.  Distinguishing Chronic Thromboembolic Pulmonary Hypertension From Other Causes of Pulmonary Hypertension Using CT. , 2017, AJR. American journal of roentgenology.

[42]  R. Frantz,et al.  Unraveling the RV Ejection Doppler Envelope: Insight Into Pulmonary Artery Hemodynamics and Disease Severity. , 2017, JACC. Cardiovascular imaging.

[43]  M. Jinzaki,et al.  Diagnostic accuracy of lung subtraction iodine mapping CT for the evaluation of pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension: Correlation with perfusion SPECT/CT. , 2017, International journal of cardiology.

[44]  S. Sakao,et al.  Mosaic attenuation pattern in non-contrast computed tomography for the assessment of pulmonary perfusion in chronic thromboembolic pulmonary hypertension. , 2017, Respiratory investigation.

[45]  J. Kasprzak,et al.  Imaging the right heart pulmonary circulation unit: Insights from advanced ultrasound techniques , 2017, Echocardiography.

[46]  J. Wild,et al.  Magnetic Resonance Imaging in the Prognostic Evaluation of Patients with Pulmonary Arterial Hypertension , 2017, American journal of respiratory and critical care medicine.

[47]  T. Kolb,et al.  Improvement in Right Ventricular Strain with Ambrisentan and Tadalafil Upfront Therapy in Scleroderma-associated Pulmonary Arterial Hypertension. , 2017, American journal of respiratory and critical care medicine.

[48]  Xiaofei Gao,et al.  Targeted drugs for pulmonary arterial hypertension: a network meta-analysis of 32 randomized clinical trials , 2017, Patient preference and adherence.

[49]  N. Screaton,et al.  Imaging of acute and chronic thromboembolic disease: state of the art. , 2017, Clinical radiology.

[50]  D. Ivy,et al.  Tricuspid annular plane systolic excursion is preserved in young patients with pulmonary hypertension except when associated with repaired congenital heart disease , 2017, European heart journal cardiovascular Imaging.

[51]  J. Remy,et al.  Lung perfusion characteristics in pulmonary arterial hypertension (PAH) and peripheral forms of chronic thromboembolic pulmonary hypertension (pCTEPH): Dual-energy CT experience in 31 patients , 2017, European Radiology.

[52]  M. Zeng,et al.  Association of native T1 times with biventricular function and hemodynamics in precapillary pulmonary hypertension , 2017, The International Journal of Cardiovascular Imaging.

[53]  Justin D. Roberts,et al.  Follow-up tricuspid annular plane systolic excursion predicts survival in pulmonary arterial hypertension , 2017, Pulmonary circulation.

[54]  A. Leung,et al.  Left Atrium Maximal Axial Cross-Sectional Area is a Specific Computed Tomographic Imaging Biomarker of World Health Organization Group 2 Pulmonary Hypertension , 2017, Journal of thoracic imaging.

[55]  A. Swift,et al.  Idiopathic and Systemic Sclerosis‐Associated Pulmonary Arterial Hypertension: A Comparison of Demographic, Hemodynamic, and MRI Characteristics and Outcomes , 2017, Chest.

[56]  Hamid Jafarkhani,et al.  Automatic segmentation of the right ventricle from cardiac MRI using a learning‐based approach , 2017, Magnetic resonance in medicine.

[57]  Daniel Rueckert,et al.  Machine Learning of Three-dimensional Right Ventricular Motion Enables Outcome Prediction in Pulmonary Hypertension: A Cardiac MR Imaging Study , 2017, Radiology.

[58]  V. Muthurangu,et al.  Magnetic Resonance-Augmented Cardiopulmonary Exercise Testing: Comprehensively Assessing Exercise Intolerance in Children With Cardiovascular Disease. , 2016, Circulation. Cardiovascular imaging.

[59]  R. Naeije,et al.  Simple functional imaging of the right ventricle in pulmonary hypertension: Can right ventricular ejection fraction be improved? , 2016, International journal of cardiology.

[60]  J. Marcus,et al.  CTA-derived left to right atrial size ratio distinguishes between pulmonary hypertension due to heart failure and idiopathic pulmonary arterial hypertension. , 2016, International journal of cardiology.

[61]  A. Hamvas,et al.  Pulmonary Artery Acceleration Time Provides a Reliable Estimate of Invasive Pulmonary Hemodynamics in Children. , 2016, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[62]  A. Carusi,et al.  A social‐technological epistemology of clinical decision‐making as mediated by imaging , 2016, Journal of evaluation in clinical practice.

[63]  E. V. van Beek,et al.  Dynamic (4D) CT perfusion offers simultaneous functional and anatomical insights into pulmonary embolism resolution. , 2016, European journal of radiology.

[64]  M. Uetani,et al.  Quantification of lung perfusion blood volume (lung PBV) by dual-energy CT in patients with chronic thromboembolic pulmonary hypertension (CTEPH) before and after balloon pulmonary angioplasty (BPA): Preliminary results. , 2016, European journal of radiology.

[65]  N. Chesler,et al.  Imaging right ventricular function to predict outcome in pulmonary arterial hypertension. , 2016, International journal of cardiology.

[66]  H. Shimokawa,et al.  Dual-energy CT to estimate clinical severity of chronic thromboembolic pulmonary hypertension: Comparison with invasive right heart catheterization. , 2016, European journal of radiology.

[67]  J. Basha,et al.  Pulmonary Hypertension Due to Left Heart Disease , 2016, Indian Journal of Cardiovascular Disease in Women WINCARS.

[68]  Sanjiv J. Shah,et al.  Reduced haemodynamic coupling and exercise are associated with vascular stiffening in pulmonary arterial hypertension , 2016, Heart.

[69]  Carlos D Davila,et al.  Methods for Evaluating Right Ventricular Function and Ventricular-Arterial Coupling. , 2016, Progress in cardiovascular diseases.

[70]  V. Fuster,et al.  Characterization and clinical significance of right ventricular mechanics in pulmonary hypertension evaluated with cardiovascular magnetic resonance feature tracking , 2016, Journal of Cardiovascular Magnetic Resonance.

[71]  F. Wacker,et al.  MR Imaging-derived Regional Pulmonary Parenchymal Perfusion and Cardiac Function for Monitoring Patients with Chronic Thromboembolic Pulmonary Hypertension before and after Pulmonary Endarterectomy. , 2016, Radiology.

[72]  Michael Markl,et al.  MR and CT Imaging for the Evaluation of Pulmonary Hypertension. , 2016, JACC. Cardiovascular imaging.

[73]  A. Lungu,et al.  Diagnosis of Pulmonary Hypertension from Magnetic Resonance Imaging–Based Computational Models and Decision Tree Analysis , 2016, Pulmonary circulation.

[74]  M. Goumans,et al.  Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle , 2016, Circulation.

[75]  S. Ghio,et al.  Prognostic value of TAPSE after therapy optimisation in patients with pulmonary arterial hypertension is independent of the haemodynamic effects of therapy , 2016, Open Heart.

[76]  J. Wells,et al.  Pulmonary Artery Enlargement Is Associated With Cardiac Injury During Severe Exacerbations of COPD. , 2016, Chest.

[77]  A. Greiser,et al.  Native myocardial T1 mapping in pulmonary hypertension: correlations with cardiac function and hemodynamics , 2016, European Radiology.

[78]  Shao-Liang Chen,et al.  Pulmonary Artery Denervation for Treatment of a Patient with Pulmonary Hypertension Secondary to Left Heart Disease , 2016, Pulmonary circulation.

[79]  U. Reiter,et al.  MR phase-contrast imaging in pulmonary hypertension , 2016, The British journal of radiology.

[80]  M. Balaan,et al.  Acute Respiratory Distress Syndrome , 2016, Critical care nursing quarterly.

[81]  J. Remy,et al.  Impact of CT perfusion imaging on the assessment of peripheral chronic pulmonary thromboembolism: clinical experience in 62 patients , 2016, European Radiology.

[82]  A. Yamada,et al.  Prognostic value of right ventricular free wall strain in pulmonary hypertension patients with pseudo-normalized tricuspid annular plane systolic excursion values , 2016, The International Journal of Cardiovascular Imaging.

[83]  D. Ivy,et al.  Three-dimensional Echocardiography of Right Ventricular Function Correlates with Severity of Pediatric Pulmonary Hypertension. , 2016, Congenital heart disease.

[84]  Raúl San José Estépar,et al.  Pulmonary Vascular Morphology as an Imaging Biomarker in Chronic Thromboembolic Pulmonary Hypertension , 2016, Pulmonary circulation.

[85]  Héctor Bueno,et al.  Guía ESC/ERS 2015 sobre diagnóstico y tratamiento de la hipertensión pulmonar , 2016 .

[86]  Simon Gibbs,et al.  2015 ESC/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension. , 2016, Revista espanola de cardiologia.

[87]  A. Swift,et al.  Pulmonary Hypertension in Patients with Heart Failure and Preserved Ejection Fraction: Differential Diagnosis and Management , 2016, Pulmonary circulation.

[88]  V. Tapson,et al.  Abnormalities in Hyperpolarized 129Xe Magnetic Resonance Imaging and Spectroscopy in two Patients with Pulmonary Vascular Disease , 2016, Pulmonary circulation.

[89]  G. Hansmann,et al.  Transthoracic Echocardiography in the Evaluation of Pediatric Pulmonary Hypertension and Ventricular Dysfunction , 2016, Pulmonary circulation.

[90]  Hamid Jafarkhani,et al.  A combined deep-learning and deformable-model approach to fully automatic segmentation of the left ventricle in cardiac MRI , 2015, Medical Image Anal..

[91]  A. Peacock,et al.  Imaging the heart in pulmonary hypertension: an update , 2015, European Respiratory Review.

[92]  W. Chung,et al.  Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society , 2015, Circulation.

[93]  J. Gunn,et al.  Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary Hypertension , 2015, Circulation. Cardiovascular interventions.

[94]  E. Bossone,et al.  Echocardiography in pulmonary hypertension , 2015, Current opinion in cardiology.

[95]  J. Gunn,et al.  Computational fluid dynamics modelling in cardiovascular medicine , 2015, Heart.

[96]  J. Marcus,et al.  Increased native T1-values at the interventricular insertion regions in precapillary pulmonary hypertension , 2015, The International Journal of Cardiovascular Imaging.

[97]  M. Markl,et al.  4D flow cardiovascular magnetic resonance consensus statement , 2015, Journal of Cardiovascular Magnetic Resonance.

[98]  Matt A. Bernstein,et al.  Cardiovascular magnetic resonance phase contrast imaging , 2015, Journal of Cardiovascular Magnetic Resonance.

[99]  C. McCracken,et al.  Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients , 2015, Echocardiography.

[100]  M. Friedberg,et al.  Left Ventricular Myocardial Function in Children With Pulmonary Hypertension: Relation to Right Ventricular Performance and Hemodynamics. , 2015, Circulation. Cardiovascular imaging.

[101]  P. Wenaweser,et al.  Effect of Pulmonary Hypertension Hemodynamic Presentation on Clinical Outcomes in Patients With Severe Symptomatic Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Implantation: Insights From the New Proposed Pulmonary Hypertension Classification , 2015, Circulation. Cardiovascular interventions.

[102]  Serghei Cebotari,et al.  Performance of perfusion‐weighted Fourier decomposition MRI for detection of chronic pulmonary emboli , 2015, Journal of magnetic resonance imaging : JMRI.

[103]  R. Staff,et al.  Planar and SPECT ventilation/perfusion imaging and computed tomography for the diagnosis of pulmonary embolism: A systematic review and meta-analysis of the literature, and cost and dose comparison. , 2015, European journal of radiology.

[104]  Jeffrey Mueller,et al.  Patient-specific computational modeling of blood flow in the pulmonary arterial circulation , 2015, Comput. Methods Programs Biomed..

[105]  J. Wild,et al.  Right Ventricular Sex Differences in Patients with Idiopathic Pulmonary Arterial Hypertension Characterised by Magnetic Resonance Imaging: Pair-Matched Case Controlled Study , 2015, PloS one.

[106]  D. Bluemke,et al.  Normal values for cardiovascular magnetic resonance in adults and children , 2015, Journal of Cardiovascular Magnetic Resonance.

[107]  R. Naeije Assessment of Right Ventricular Function in Pulmonary Hypertension , 2015, Current Hypertension Reports.

[108]  Horst Olschewski,et al.  Blood flow vortices along the main pulmonary artery measured with MR imaging for diagnosis of pulmonary hypertension. , 2015, Radiology.

[109]  N. Hill,et al.  A computational study of pressure wave reflections in the pulmonary arteries , 2015, Journal of mathematical biology.

[110]  C. Fischer,et al.  Reference Ranges for and Determinants of Right Ventricular Area in Healthy Adults by Two-Dimensional Echocardiography , 2015, Respiration.

[111]  S. Solomon,et al.  Effect of imatinib as add-on therapy on echocardiographic measures of right ventricular function in patients with significant pulmonary arterial hypertension. , 2015, European heart journal.

[112]  C. Gaudio,et al.  Three‐Dimensional Echocardiography and 2D‐3D Speckle‐Tracking Imaging in Chronic Pulmonary Hypertension: Diagnostic Accuracy in Detecting Hemodynamic Signs of Right Ventricular (RV) Failure , 2015, Journal of the American Heart Association.

[113]  Srinivas Murali,et al.  The Role of Wall Shear Stress in the Assessment of Right Ventricle Hydraulic Workload , 2015, Pulmonary circulation.

[114]  Stefan L. Zimmerman,et al.  Comparison of strain measurement from multimodality tissue tracking with strain-encoding MRI and harmonic phase MRI in pulmonary hypertension. , 2015, International journal of cardiology.

[115]  M. Quail,et al.  Accuracy and Reproducibility of Right Ventricular Quantification in Patients with Pressure and Volume Overload Using Single-Beat Three-Dimensional Echocardiography , 2015, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[116]  Victor Mor-Avi,et al.  Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. , 2015, European heart journal cardiovascular Imaging.

[117]  M. Quail,et al.  Noninvasive pulmonary artery wave intensity analysis in pulmonary hypertension , 2015, American Journal of Physiology. Heart and Circulatory Physiology.

[118]  G. Di Salvo,et al.  Pulmonary Arterial Hypertension: The Key Role of Echocardiography , 2015, Echocardiography.

[119]  H. Hillege,et al.  Echocardiography in pediatric pulmonary arterial hypertension: early study on assessing disease severity and predicting outcome. , 2014, Circulation. Cardiovascular imaging.

[120]  A. Swift,et al.  CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry , 2014, Thorax.

[121]  J. Wild,et al.  LGE patterns in pulmonary hypertension do not impact overall mortality. , 2014, JACC. Cardiovascular imaging.

[122]  C. Xiong,et al.  Oral targeted therapies in the treatment of pulmonary arterial hypertension: a meta-analysis of clinical trials. , 2014, Pulmonary pharmacology & therapeutics.

[123]  K. Okumura,et al.  Longitudinal assessment of right ventricular myocardial strain in relation to transplant-free survival in children with idiopathic pulmonary hypertension. , 2014, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[124]  D. Ivy,et al.  Echocardiography in Pediatric Pulmonary Hypertension , 2014, Front. Pediatr..

[125]  B. Madden,et al.  Dual-energy CT for imaging of pulmonary hypertension: challenges and opportunities. , 2014, Radiographics : a review publication of the Radiological Society of North America, Inc.

[126]  A. Galdó,et al.  Assessing Pulmonary Hypertensive Vascular Disease in Childhood. Data from the Spanish Registry , 2014 .

[127]  W. Seeger,et al.  Updated treatment algorithm of pulmonary arterial hypertension. , 2013, Journal of the American College of Cardiology.

[128]  D. Badesch,et al.  [Definitions and diagnosis of pulmonary hypertension]. , 2014, Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir.

[129]  A. Lungu,et al.  MRI model-based non-invasive differential diagnosis in pulmonary hypertension. , 2014, Journal of biomechanics.

[130]  M. Pinsky,et al.  RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension , 2014, Heart.

[131]  E. V. van Beek,et al.  Magnetic resonance imaging of ventilation and perfusion changes in response to pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. , 2014, American journal of respiratory and critical care medicine.

[132]  Thoralf M Sundt,et al.  2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. , 2014, Journal of the American College of Cardiology.

[133]  J. Marcus,et al.  State of the Art: Advanced Imaging of the Right Ventricle and Pulmonary Circulation in Humans (2013 Grover Conference Series) , 2014, Pulmonary circulation.

[134]  Angelo Branzi,et al.  Current era survival of patients with pulmonary arterial hypertension associated with congenital heart disease: a comparison between clinical subgroups. , 2014, European heart journal.

[135]  Mette S Olufsen,et al.  Numerical simulation of blood flow and pressure drop in the pulmonary arterial and venous circulation , 2014, Biomechanics and modeling in mechanobiology.

[136]  E. V. van Beek,et al.  Quantitative Magnetic Resonance Imaging of Pulmonary Hypertension: A Practical Approach to the Current State of the Art , 2014, Journal of thoracic imaging.

[137]  B. Madden,et al.  Dual-energy Computed Tomography in the Assessment of Vascular and Parenchymal Enhancement in Suspected Pulmonary Hypertension , 2014, Journal of thoracic imaging.

[138]  H. Marshall,et al.  Dynamic Contrast–Enhanced Magnetic Resonance Imaging in Patients with Pulmonary Arterial Hypertension , 2014, Pulmonary circulation.

[139]  R. Stollberger,et al.  Non-invasive determination of pulmonary hypertension with dynamic contrast-enhanced computed tomography: a pilot study , 2014, European Radiology.

[140]  D. Ivy,et al.  Right ventricular to left ventricular diameter ratio at end-systole in evaluating outcomes in children with pulmonary hypertension. , 2014, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[141]  W. Chung,et al.  EIF2AK4 mutations in pulmonary capillary hemangiomatosis. , 2014, Chest.

[142]  M. Urschler,et al.  Quantification of Tortuosity and Fractal Dimension of the Lung Vessels in Pulmonary Hypertension Patients , 2014, PloS one.

[143]  B. Schnackenburg,et al.  Classification of diastolic function with phase-contrast cardiac magnetic resonance imaging: validation with echocardiography and age-related reference values , 2014, Clinical Research in Cardiology.

[144]  J. Marcus,et al.  Changes in Right Ventricular Function Measured by Cardiac Magnetic Resonance Imaging in Patients Receiving Pulmonary Arterial Hypertension–Targeted Therapy: The EURO-MR Study , 2014, Circulation. Cardiovascular imaging.

[145]  J. Wild,et al.  Prognostic Value of Cardiovascular Magnetic Resonance Imaging Measurements Corrected for Age and Sex in Idiopathic Pulmonary Arterial Hypertension , 2014, Circulation. Cardiovascular imaging.

[146]  T. Fleming,et al.  Pediatric pulmonary hypertension. , 2013, Journal of the American College of Cardiology.

[147]  W. Seeger,et al.  Algorithm of Pulmonary Arterial Hypertension , 2022 .

[148]  Toru Satoh,et al.  Definitions and diagnosis of pulmonary hypertension. , 2013, Journal of the American College of Cardiology.

[149]  Horst Olschewski,et al.  Evaluation of Elevated Mean Pulmonary Arterial Pressure Based on Magnetic Resonance 4D Velocity Mapping: Comparison of Visualization Techniques , 2013, PloS one.

[150]  M. Humbert,et al.  EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension , 2013, Nature Genetics.

[151]  N. Galiè,et al.  New horizons in pulmonary arterial hypertension therapies , 2013, European Respiratory Review.

[152]  L. Sinak,et al.  Pericardial effusions in pulmonary arterial hypertension: characteristics, prognosis, and role of drainage. , 2013, Chest.

[153]  C. Fischer,et al.  Assessment and Prognostic Relevance of Right Ventricular Contractile Reserve in Patients With Severe Pulmonary Hypertension , 2013, Circulation.

[154]  B. Boerrigter,et al.  Risk Factors for Hemoptysis in Idiopathic and Hereditary Pulmonary Arterial Hypertension , 2013, PloS one.

[155]  Emanuele Romeo,et al.  Accuracy and precision of echocardiography versus right heart catheterization for the assessment of pulmonary hypertension. , 2013, International journal of cardiology.

[156]  A. Morton,et al.  Noninvasive estimation of PA pressure, flow, and resistance with CMR imaging: derivation and prospective validation study from the ASPIRE registry. , 2013, JACC. Cardiovascular imaging.

[157]  G. Stone,et al.  Pulmonary artery denervation to treat pulmonary arterial hypertension: the single-center, prospective, first-in-man PADN-1 study (first-in-man pulmonary artery denervation for treatment of pulmonary artery hypertension). , 2013, Journal of the American College of Cardiology.

[158]  P. Pellikka,et al.  Outcome Prediction by Quantitative Right Ventricular Function Assessment in 575 Subjects Evaluated for Pulmonary Hypertension , 2013, Circulation. Cardiovascular imaging.

[159]  J. Mazurek,et al.  Enhancing the accuracy of echocardiography in the diagnosis of pulmonary arterial hypertension: looking at the heart to learn about the lungs , 2013, Current opinion in pulmonary medicine.

[160]  Ami A. Shah,et al.  Right Ventricular Dysfunction in Systemic Sclerosis–Associated Pulmonary Arterial Hypertension , 2013, Circulation. Heart failure.

[161]  M. Goddard,et al.  Primary pulmonary artery sarcoma and coexisting chronic thromboembolic pulmonary hypertension. , 2013, American journal of respiratory and critical care medicine.

[162]  R. Stollberger,et al.  Determination of cardiac output with dynamic contrast-enhanced computed tomography , 2013, The International Journal of Cardiovascular Imaging.

[163]  S. Pullamsetti,et al.  Heterogeneity in Lung 18FDG Uptake in Pulmonary Arterial Hypertension: Potential of Dynamic 18FDG Positron Emission Tomography With Kinetic Analysis as a Bridging Biomarker for Pulmonary Vascular Remodeling Targeted Treatments , 2013, Circulation.

[164]  S. Toyooka,et al.  Different sizes of centrilobular ground-glass opacities in chest high-resolution computed tomography of patients with pulmonary veno-occlusive disease and patients with pulmonary capillary hemangiomatosis. , 2013, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[165]  S. Fanti,et al.  Pulmonary artery intimal sarcoma. Problems in the differential diagnosis , 2013, La radiologia medica.

[166]  A. Taylor,et al.  Guidelines and protocols for cardiovascular magnetic resonance in children and adults with congenital heart disease: SCMR expert consensus group on congenital heart disease , 2013, Journal of Cardiovascular Magnetic Resonance.

[167]  G. Ferretti,et al.  ECG-gated computed tomography to assess pulmonary capillary wedge pressure in pulmonary hypertension , 2013, European Radiology.

[168]  M. Friedberg,et al.  Prognostic significance of 2-dimensional, M-mode, and Doppler echo indices of right ventricular function in children with pulmonary arterial hypertension. , 2013, American heart journal.

[169]  H. Heinzl,et al.  Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study , 2013, Annals of the rheumatic diseases.

[170]  A. Taylor,et al.  Prognostic Significance of Cardiac Magnetic Resonance Imaging in Children With Pulmonary Hypertension , 2013, Circulation. Cardiovascular imaging.

[171]  Shao-Liang Chen,et al.  Pulmonary arterial hypertension: pharmacologic therapies and potential pulmonary artery denervation treatment. , 2013, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.

[172]  D. Kiely,et al.  Pulmonary hypertension: diagnosis and management , 2013, BMJ : British Medical Journal.

[173]  Dudley J Pennell,et al.  Reference right atrial dimensions and volume estimation by steady state free precession cardiovascular magnetic resonance , 2013, Journal of Cardiovascular Magnetic Resonance.

[174]  Reza Razavi,et al.  Native T1 mapping in differentiation of normal myocardium from diffuse disease in hypertrophic and dilated cardiomyopathy. , 2013, JACC. Cardiovascular imaging.

[175]  M. Holland,et al.  Doppler echocardiography inaccurately estimates right ventricular pressure in children with elevated right heart pressure. , 2013, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[176]  H. Ghofrani,et al.  Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension: Results of the Randomized IMPRES Study , 2013, Circulation.

[177]  J. Barberà,et al.  Sildenafil to improve respiratory rehabilitation outcomes in COPD: a controlled trial , 2013, European Respiratory Journal.

[178]  N. Chesler,et al.  Methods for Measuring Right Ventricular Function and Hemodynamic Coupling with the Pulmonary Vasculature , 2013, Annals of Biomedical Engineering.

[179]  N. Osman,et al.  The strain-encoded (SENC) MR imaging for detection of global right ventricular dysfunction in pulmonary hypertension , 2013, The International Journal of Cardiovascular Imaging.

[180]  H. Marshall,et al.  3D contrast-enhanced lung perfusion MRI is an effective screening tool for chronic thromboembolic pulmonary hypertension: results from the ASPIRE Registry , 2013, Thorax.

[181]  D. Ivy,et al.  Tissue Doppler imaging predicts adverse outcome in children with idiopathic pulmonary arterial hypertension. , 2012, The Journal of pediatrics.

[182]  J. Afilalo,et al.  A Simple Echocardiographic Prediction Rule for Hemodynamics in Pulmonary Hypertension , 2012, Circulation. Cardiovascular imaging.

[183]  S. Cross,et al.  Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension , 2012, The Journal of experimental medicine.

[184]  J. Wild,et al.  Pulmonary Artery Relative Area Change Detects Mild Elevations in Pulmonary Vascular Resistance and Predicts Adverse Outcome in Pulmonary Hypertension , 2012, Investigative radiology.

[185]  J. Wild,et al.  Pulmonary hypertension in COPD: results from the ASPIRE registry , 2012, European Respiratory Journal.

[186]  M. Humbert,et al.  Computed tomography findings of pulmonary venoocclusive disease in scleroderma patients presenting with precapillary pulmonary hypertension. , 2012, Arthritis and rheumatism.

[187]  G. Ferretti,et al.  Pulmonary artery and right ventricle assessment in pulmonary hypertension: correlation between functional parameters of ECG-gated CT and right-side heart catheterization , 2012, Acta radiologica.

[188]  Luke S. Howard,et al.  Echocardiographic assessment of pulmonary hypertension: standard operating procedure , 2012, European Respiratory Review.

[189]  Mette S Olufsen,et al.  Rarefaction and blood pressure in systemic and pulmonary arteries , 2012, Journal of Fluid Mechanics.

[190]  W. Fang,et al.  Comparison of 18F-FDG uptake by right ventricular myocardium in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease , 2012, Pulmonary circulation.

[191]  Jim M Wild,et al.  Diagnostic accuracy of cardiovascular magnetic resonance imaging of right ventricular morphology and function in the assessment of suspected pulmonary hypertension results from the ASPIRE registry , 2012, Journal of Cardiovascular Magnetic Resonance.

[192]  James O. Mudd,et al.  Pulmonary arterial hypertension: MR imaging-derived first-pass bolus kinetic parameters are biomarkers for pulmonary hemodynamics, cardiac function, and ventricular remodeling. , 2012, Radiology.

[193]  K. Kerr,et al.  Pulmonary Circulation | April-june 2012 | Vol 2 | No 2 Review Ar Ticle Evaluation of Patients with Chronic Thromboembolic Pulmonary Hypertension for Pulmonary Endarterectomy Clinical Presentation , 2022 .

[194]  S. Archer,et al.  Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension. , 2012, American journal of respiratory and critical care medicine.

[195]  M. Mcgoon,et al.  REVEAL: a contemporary US pulmonary arterial hypertension registry , 2012, European Respiratory Review.

[196]  S. Ley,et al.  Diagnostic performance of state-of-the-art imaging techniques for morphological assessment of vascular abnormalities in patients with chronic thromboembolic pulmonary hypertension (CTEPH) , 2012, European Radiology.

[197]  H. Marshall,et al.  Black blood MRI has diagnostic and prognostic value in the assessment of patients with pulmonary hypertension , 2012, European Radiology.

[198]  Amit R. Patel,et al.  Late gadolinium enhancement cardiovascular magnetic resonance predicts clinical worsening in patients with pulmonary hypertension , 2012, Journal of Cardiovascular Magnetic Resonance.

[199]  J. Wild,et al.  Diagnostic accuracy of contrast-enhanced MR angiography and unenhanced proton MR imaging compared with CT pulmonary angiography in chronic thromboembolic pulmonary hypertension , 2012, European Radiology.

[200]  R. Mohiaddin,et al.  Cardiovascular magnetic resonance in pulmonary hypertension , 2012, Journal of Cardiovascular Magnetic Resonance.

[201]  Nico Westerhof,et al.  Pulmonary endarterectomy normalizes interventricular dyssynchrony and right ventricular systolic wall stress , 2012, Journal of Cardiovascular Magnetic Resonance.

[202]  Udo Hoffmann,et al.  Reference Values for Normal Pulmonary Artery Dimensions by Noncontrast Cardiac Computed Tomography: The Framingham Heart Study , 2012, Circulation. Cardiovascular imaging.

[203]  Nico Westerhof,et al.  Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy. , 2011, Journal of the American College of Cardiology.

[204]  B. Griffith,et al.  Pulmonary hypertension adversely affects short- and long-term survival after mitral valve operation for mitral regurgitation: implications for timing of surgery. , 2011, The Journal of thoracic and cardiovascular surgery.

[205]  James O. Mudd,et al.  Tricuspid Annular Plane Systolic Excursion Is a Robust Outcome Measure in Systemic Sclerosis-associated Pulmonary Arterial Hypertension , 2011, The Journal of Rheumatology.

[206]  V. Fuster,et al.  Right ventriculo-arterial coupling in pulmonary hypertension: a magnetic resonance study , 2011, Heart.

[207]  J. Wild,et al.  ASPIRE registry: Assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre , 2011, European Respiratory Journal.

[208]  Grzegorz Bauman,et al.  Pulmonary functional imaging: qualitative comparison of Fourier decomposition MR imaging with SPECT/CT in porcine lung. , 2011, Radiology.

[209]  E. V. van Beek,et al.  CT pulmonary angiography combined with echocardiography in suspected systemic sclerosis-associated pulmonary arterial hypertension. , 2011, Rheumatology.

[210]  R. Kronmal,et al.  Sex and Race Differences in Right Ventricular Structure and Function: The Multi-Ethnic Study of Atherosclerosis–Right Ventricle Study , 2011, Circulation.

[211]  P. Pellikka,et al.  Right ventricular strain for prediction of survival in patients with pulmonary arterial hypertension. , 2011, Chest.

[212]  M. Mcgoon,et al.  Integration of clinical and hemodynamic parameters in the prediction of long-term survival in patients with pulmonary arterial hypertension. , 2011, Chest.

[213]  Sanjiv J Shah,et al.  Inaccuracy of Doppler echocardiographic estimates of pulmonary artery pressures in patients with pulmonary hypertension: implications for clinical practice. , 2011, Chest.

[214]  J. Babb,et al.  Sex-specific normalized reference values of heart and great vessel dimensions in cardiac CT angiography. , 2011, AJR. American journal of roentgenology.

[215]  S. Mirsadraee,et al.  Dual-energy CT angiography for assessment of regional pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension: initial experience. , 2011, AJR. American journal of roentgenology.

[216]  J. Remy,et al.  Chest computed tomography using iterative reconstruction vs filtered back projection (Part 2): image quality of low-dose CT examinations in 80 patients , 2011, European Radiology.

[217]  A. Taylor,et al.  Fractal branching quantifies vascular changes and predicts survival in pulmonary hypertension: a proof of principle study , 2011, Heart.

[218]  Jeroen J. Bax,et al.  Left ventricular diastolic function assessment from three‐dimensional three‐directional velocity‐encoded MRI with retrospective valve tracking , 2011, Journal of magnetic resonance imaging : JMRI.

[219]  V. Ferrari,et al.  Shape of the right ventricular Doppler envelope predicts hemodynamics and right heart function in pulmonary hypertension. , 2011, American journal of respiratory and critical care medicine.

[220]  C. Hoh,et al.  Single photon emission computed tomography in chronic thromboembolic pulmonary hypertension , 2011, Respirology.

[221]  N. Westerhof,et al.  Progressive dilatation of the main pulmonary artery is a characteristic of pulmonary arterial hypertension and is not related to changes in pressure. , 2010, Chest.

[222]  Jens Frahm,et al.  Real‐time MRI at a resolution of 20 ms , 2010, NMR in biomedicine.

[223]  M. Friedberg,et al.  Imaging the right ventricle—current state of the art , 2010, Nature Reviews Cardiology.

[224]  B. McCrindle,et al.  Usefulness of the right ventricular systolic to diastolic duration ratio to predict functional capacity and survival in children with pulmonary arterial hypertension. , 2010, The American journal of cardiology.

[225]  MarcHumbert,et al.  Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era , 2010 .

[226]  M. Sheppard,et al.  Understanding late gadolinium enhancement in pulmonary hypertension. , 2010, Circulation. Cardiovascular imaging.

[227]  N. Bellenger,et al.  A comparison of radiation doses between state-of-the-art multislice CT coronary angiography with iterative reconstruction, multislice CT coronary angiography with standard filtered back-projection and invasive diagnostic coronary angiography , 2010, Heart.

[228]  Chao-shu Tang,et al.  Meta-analysis of randomized controlled trials on treatment of pulmonary arterial hypertension. , 2010, Circulation journal : official journal of the Japanese Circulation Society.

[229]  Raúl San José Estépar,et al.  Pulmonary hypertension and computed tomography measurement of small pulmonary vessels in severe emphysema. , 2010, American journal of respiratory and critical care medicine.

[230]  Anand Devaraj,et al.  Detection of pulmonary hypertension with multidetector CT and echocardiography alone and in combination. , 2010, Radiology.

[231]  D. Gopalan,et al.  Dual energy CT pulmonary angiography: findings in a patient with chronic thromboembolic pulmonary hypertension , 2009, Thorax.

[232]  G. Simonneau,et al.  The use of combination therapy in pulmonary arterial hypertension: new developments , 2009, European Respiratory Review.

[233]  M. Galanski,et al.  Chronic thromboembolic pulmonary hypertension: evaluation with 64-detector row CT versus digital substraction angiography. , 2009, European journal of radiology.

[234]  Robin Shandas,et al.  Effects of Pathological Flow on Pulmonary Artery Endothelial Production of Vasoactive Mediators and Growth Factors , 2009, Journal of Vascular Research.

[235]  H. Ghofrani,et al.  Updated evidence-based treatment algorithm in pulmonary arterial hypertension. , 2009, Journal of the American College of Cardiology.

[236]  W. Ravekes,et al.  Right ventricular function in infants, children and adolescents: reference values of the tricuspid annular plane systolic excursion (TAPSE) in 640 healthy patients and calculation of z score values. , 2009, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[237]  E. Gasparetto,et al.  Myocardial delayed enhancement in patients with pulmonary hypertension and right ventricular failure: evaluation by cardiac MRI. , 2009, The British journal of radiology.

[238]  Mario J. Garcia,et al.  Evaluation of pulmonary artery stiffness in pulmonary hypertension with cardiac magnetic resonance. , 2009, JACC. Cardiovascular imaging.

[239]  M. Humbert,et al.  Stress Doppler Echocardiography in Relatives of Patients With Idiopathic and Familial Pulmonary Arterial Hypertension: Results of a Multicenter European Analysis of Pulmonary Artery Pressure Response to Exercise and Hypoxia , 2009, Circulation.

[240]  J. Remy,et al.  Pulmonary hypertension: ECG-gated 64-section CT angiographic evaluation of new functional parameters as diagnostic criteria. , 2009, Radiology.

[241]  A. Torbicki,et al.  Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial. , 2008, Journal of the American College of Cardiology.

[242]  D. Hansell,et al.  The effect of diffuse pulmonary fibrosis on the reliability of CT signs of pulmonary hypertension. , 2008, Radiology.

[243]  N. Westerhof,et al.  Non-invasive stroke volume assessment in patients with pulmonary arterial hypertension: left-sided data mandatory , 2008, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[244]  R. Naeije,et al.  Pulmonary hypertension in COPD , 2008, European Respiratory Journal.

[245]  E. V. van Beek,et al.  Cavitating lung lesions in chronic thromboembolic pulmonary hypertension. , 2008, Journal of radiology case reports.

[246]  M. Fawzy,et al.  Immediate and long-term results of mitral balloon valvuloplasty in patients with severe pulmonary hypertension. , 2008, The Journal of heart valve disease.

[247]  M. Humbert,et al.  Pulmonary Veno-Occlusive Disease: Clinical, Functional, Radiologic, and Hemodynamic Characteristics and Outcome of 24 Cases Confirmed by Histology , 2008, Medicine.

[248]  Horst Olschewski,et al.  Magnetic Resonance–Derived 3-Dimensional Blood Flow Patterns in the Main Pulmonary Artery as a Marker of Pulmonary Hypertension and a Measure of Elevated Mean Pulmonary Arterial Pressure , 2008, Circulation. Cardiovascular imaging.

[249]  T. Kuriyama,et al.  Dilatation of bronchial arteries correlates with extent of central disease in patients with chronic thromboembolic pulmonary hypertension. , 2008, Circulation journal : official journal of the Japanese Circulation Society.

[250]  P. Corris,et al.  Improved outcomes in medically and surgically treated chronic thromboembolic pulmonary hypertension. , 2008, American journal of respiratory and critical care medicine.

[251]  Tal Geva,et al.  Accuracy of guideline recommendations for two-dimensional quantification of the right ventricle by echocardiography , 2008, The International Journal of Cardiovascular Imaging.

[252]  N. Westerhof,et al.  Sildenafil treatment in COPD does not affect stroke volume or exercise capacity , 2008, European Respiratory Journal.

[253]  Masafumi Kitakaze,et al.  Patterns of the interventricular septal motion can predict conditions of patients with pulmonary hypertension. , 2008, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[254]  S. Hunt,et al.  Right Ventricular Function in Cardiovascular Disease, Part II: Pathophysiology, Clinical Importance, and Management of Right Ventricular Failure , 2008, Circulation.

[255]  S. Hunt,et al.  Right Ventricular Function in Cardiovascular Disease, Part I: Anatomy, Physiology, Aging, and Functional Assessment of the Right Ventricle , 2008, Circulation.

[256]  J. Bronzwaer,et al.  Right coronary artery flow impairment in patients with pulmonary hypertension. , 2007, European heart journal.

[257]  Nico Westerhof,et al.  Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension. , 2007, Chest.

[258]  H. Fessler,et al.  Estimating pulmonary artery pressures by echocardiography in patients with emphysema , 2007, European Respiratory Journal.

[259]  James A Scott,et al.  18F-FDG PET of pulmonary embolism. , 2007, AJR. American journal of roentgenology.

[260]  N. Griffin,et al.  Eisenmenger syndrome and idiopathic pulmonary arterial hypertension: do parenchymal lung changes reflect aetiology? , 2007, Clinical radiology.

[261]  P. Gishen,et al.  Ventilation–Perfusion Scintigraphy Is More Sensitive than Multidetector CTPA in Detecting Chronic Thromboembolic Pulmonary Disease as a Treatable Cause of Pulmonary Hypertension , 2007, Journal of Nuclear Medicine.

[262]  J. Bronzwaer,et al.  Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension. , 2007, European heart journal.

[263]  D. Manson,et al.  CT of the chest in the evaluation of idiopathic pulmonary arterial hypertension in children , 2007, Pediatric Radiology.

[264]  Derliz Mereles,et al.  Quantitative 3D pulmonary MR-perfusion in patients with pulmonary arterial hypertension: correlation with invasive pressure measurements. , 2007, European journal of radiology.

[265]  H. Niessen,et al.  Extent of MRI delayed enhancement of myocardial mass is related to right ventricular dysfunction in pulmonary artery hypertension. , 2007, AJR. American journal of roentgenology.

[266]  Z. Jing,et al.  Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers. , 2006, Journal of the American College of Cardiology.

[267]  Dudley J Pennell,et al.  Reference right ventricular systolic and diastolic function normalized to age, gender and body surface area from steady-state free precession cardiovascular magnetic resonance. , 2006, European heart journal.

[268]  T. Abraham,et al.  Tricuspid annular displacement predicts survival in pulmonary hypertension. , 2006, American journal of respiratory and critical care medicine.

[269]  N. Rajagopalan,et al.  Tricuspid Annular Systolic Velocity: A Useful Measurement in Determining Right Ventricular Systolic Function Regardless of Pulmonary Artery Pressures , 2006, Echocardiography.

[270]  Nico Westerhof,et al.  Quantification of right ventricular afterload in patients with and without pulmonary hypertension. , 2006, American journal of physiology. Heart and circulatory physiology.

[271]  M. Humbert,et al.  The efficacy of bosentan in inoperable chronic thromboembolic pulmonary hypertension: a 1-year follow-up study , 2006, European Respiratory Journal.

[272]  J. Foster,et al.  Contrast enhanced-cardiovascular magnetic resonance imaging in patients with pulmonary hypertension. , 2005, European heart journal.

[273]  Jeroen J. Bax,et al.  Feasibility of tissue magnetic resonance imaging: a pilot study in comparison with tissue Doppler imaging and invasive measurement. , 2005, Journal of the American College of Cardiology.

[274]  Titus Kuehne,et al.  Magnetic Resonance Imaging Analysis of Right Ventricular Pressure-Volume Loops: In Vivo Validation and Clinical Application in Patients With Pulmonary Hypertension , 2004, Circulation.

[275]  Vivek Muthurangu,et al.  Novel Method of Quantifying Pulmonary Vascular Resistance by Use of Simultaneous Invasive Pressure Monitoring and Phase-Contrast Magnetic Resonance Flow , 2004, Circulation.

[276]  J. Garot The study of diastole by tagged MRI: are we nearly there yet? , 2004, European heart journal.

[277]  D. Mccrory,et al.  Surgical treatments/interventions for pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. , 2004, Chest.

[278]  P. Corris,et al.  Interventional and surgical modalities of treatment for pulmonary arterial hypertension. , 2004, Journal of the American College of Cardiology.

[279]  Paolo Prandoni,et al.  Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. , 2004, The New England journal of medicine.

[280]  H. Ghofrani,et al.  Chronic thromboembolic pulmonary hypertension , 2004, European Respiratory Journal.

[281]  James C Moon,et al.  Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance. , 2004, American heart journal.

[282]  D. Hill,et al.  Cardiac catheterisation guided by MRI in children and adults with congenital heart disease , 2003, The Lancet.

[283]  N. Voelkel,et al.  Pulmonary vascular involvement in chronic obstructive pulmonary disease , 2003, European Respiratory Journal.

[284]  M. Thelen,et al.  Pulmonary balloon angioplasty of chronic thromboembolic pulmonary hypertension (CTEPH) in surgically inaccessible cases. , 2003, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[285]  Benoît Rondelet,et al.  Single-beat estimation of right ventricular end-systolic pressure-volume relationship. , 2003, American journal of physiology. Heart and circulatory physiology.

[286]  W. Seeger,et al.  Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension. , 2003, American journal of respiratory and critical care medicine.

[287]  J. Foster,et al.  Ventricular mass index using magnetic resonance imaging accurately estimates pulmonary artery pressure , 2002, European Respiratory Journal.

[288]  G. Koch,et al.  Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension. , 2002, Journal of the American College of Cardiology.

[289]  E. Mayer,et al.  Chronische thromboembolische pulmonale Hypertonie: Diagnostische Wertigkeit von Mehrschicht-CT und selektiver Pulmonalis-DSA , 2002 .

[290]  C. Ng,et al.  A CT sign of chronic pulmonary arterial hypertension: the ratio of main pulmonary artery to aortic diameter. , 1999, Journal of thoracic imaging.

[291]  R. Coulden,et al.  CT measurement of main pulmonary artery diameter. , 1998, The British journal of radiology.

[292]  R. Kuzo,et al.  Utility of CT scan evaluation for predicting pulmonary hypertension in patients with parenchymal lung disease. Medical College of Wisconsin Lung Transplant Group. , 1998, Chest.

[293]  Elkan F. Halpern,et al.  Relationship between pulmonary artery diameter at computed tomography and pulmonary artery pressures at right-sided heart catheterization. Massachusetts General Hospital Lung Transplantation Program. , 1997, Academic radiology.

[294]  A J Tajik,et al.  Doppler echocardiographic index for assessment of global right ventricular function. , 1996, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[295]  L. Olson,et al.  Chronic pulmonary thromboembolism: detection of regional hypoperfusion with CT. , 1994, Radiology.

[296]  J. Sandoval,et al.  Survival in primary pulmonary hypertension. Validation of a prognostic equation. , 1994, Circulation.

[297]  J. Bavaria,et al.  Measurement of end-systolic pressure-volume relations by intra-aortic balloon occlusion. , 1989, Circulation.

[298]  K. Moser,et al.  Perfusion scan findings understate the severity of angiographic and hemodynamic compromise in chronic thromboembolic pulmonary hypertension. , 1988, Chest.

[299]  E H Bergofsky,et al.  Primary pulmonary hypertension. A national prospective study. , 1987, Annals of internal medicine.

[300]  M. J. Conley,et al.  An echocardiographic index for separation of right ventricular volume and pressure overload. , 1985, Journal of the American College of Cardiology.

[301]  S. Kaul,et al.  Assessment of right ventricular function using two-dimensional echocardiography. , 1984, American heart journal.

[302]  M. Hori,et al.  ECHOCARDIOGRAPHV-DOPPLER Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique , 2005 .

[303]  N S Braunwald,et al.  Successful surgical intervention in severe chronic thromboembolic pulmonary hypertension. , 1973, Chest.

[304]  K. Phan,et al.  Medical Therapy Versus Balloon Angioplasty for CTEPH: A Systematic Review and Meta-Analysis. , 2018, Heart, lung & circulation.

[305]  G. Hansmann,et al.  Normal Reference Values and z Scores of the Pulmonary Artery Acceleration Time in Children and Its Importance for the Assessment of Pulmonary Hypertension , 2017, Circulation. Cardiovascular imaging.

[306]  D. Ivy,et al.  Right Ventricular Tissue Doppler Myocardial Performance Index in Children with Pulmonary Hypertension: Relation to Invasive Hemodynamics , 2017, Pediatric Cardiology.

[307]  M. Doyle,et al.  Does Late Gadolinium Enhancement still have Value? Right Ventricular Internal Mechanical Work, Ea/Emax and Late Gadolinium Enhancement as Prognostic Markers in Patients with Advanced Pulmonary Hypertension via Cardiac MRI. , 2017, Cardiology research and cardiovascular medicine.

[308]  田村 全 Diagnostic accuracy of lung subtraction iodine mapping CT for the evaluation of pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension : correlation with perfusion SPECT/CT(審査報告) , 2017 .

[309]  A. Torbicki,et al.  Centrilobular nodules in high resolution computed tomography of the lung in IPAH patients - preliminary data concerning clinico-radiological correlates. , 2016, Pneumonologia i alergologia polska.

[310]  F. Wacker,et al.  Comparison of C-arm Computed Tomography and Digital Subtraction Angiography in Patients with Chronic Thromboembolic Pulmonary Hypertension , 2015, CardioVascular and Interventional Radiology.

[311]  V. Fuster,et al.  Association of myocardial T1-mapping CMR with hemodynamics and RV performance in pulmonary hypertension. , 2015, JACC. Cardiovascular imaging.

[312]  Victor Mor-Avi,et al.  Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. , 2015, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[313]  Simon Gibbs,et al.  [2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension]. , 2015, Kardiologia polska.

[314]  S. Solomon,et al.  GUIDELINES AND STANDARDS , 2010 .

[315]  A. Sabaté Rotés,et al.  Assessing pulmonary hypertensive vascular disease in childhood. Data from the Spanish registry. , 2014, American journal of respiratory and critical care medicine.

[316]  M. Rubenfire,et al.  Echocardiography in pulmonary arterial hypertension: from diagnosis to prognosis. , 2013, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[317]  N. Westerhof,et al.  Accurate assessment of load-independent right ventricular systolic function in patients with pulmonary hypertension. , 2013, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[318]  D. Bluemke,et al.  Regional and global biventricular function in pulmonary arterial hypertension: a cardiac MR imaging study. , 2013, Radiology.

[319]  F. Laurent,et al.  Dual-energy CT perfusion and angiography in chronic thromboembolic pulmonary hypertension: diagnostic accuracy and concordance with radionuclide scintigraphy , 2013, European Radiology.

[320]  Biykem Bozkurt,et al.  2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. , 2013, Circulation.

[321]  H. Olschewski,et al.  [Pulmonary hypertension]. , 2012, Deutsche medizinische Wochenschrift.

[322]  David A Bluemke,et al.  Myocardial delayed enhancement in pulmonary hypertension: pulmonary hemodynamics, right ventricular function, and remodeling. , 2011, AJR. American journal of roentgenology.

[323]  D. Bluemke,et al.  Right and left ventricular myocardial perfusion reserves correlate with right ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension. , 2011, Radiology.

[324]  C. McCollough,et al.  Dose reduction in helical CT: dynamically adjustable z-axis X-ray beam collimation. , 2010, AJR. American journal of roentgenology.

[325]  W. Fang,et al.  [Value of radionuclide lung scintigraphy in the diagnosis and quantitative analysis of chronic thromboembolic pulmonary hypertension]. , 2008, Zhonghua xin xue guan bing za zhi.

[326]  K. Murase,et al.  Primary pulmonary hypertension: 3D dynamic perfusion MRI for quantitative analysis of regional pulmonary perfusion. , 2007, AJR. American journal of roentgenology.

[327]  M. Thelen,et al.  [Chronic thromboembolic pulmonary hypertension: diagnostic impact of Multislice-CT and selective Pulmonary-DSA]. , 2002, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[328]  Kluwer Academic Publishers The international journal of cardiovascular imaging , 2001 .

[329]  T. McLoud,et al.  Relationship between pulmonary artery diameter at computed tomography and pulmonary artery pressures at right-sided heart catheterization. Massachusetts General Hospital Lung Transplantation Program. , 1997, Academic radiology.

[330]  HighWire Press European respiratory review : an official journal of the European Respiratory Society. , 1991 .