Epidermal changes associated with symptomatic resolution of dandruff: biomarkers of scalp health

Background  Dandruff is a common scalp condition characterized by flakes, pruritus and sometimes mild erythema. These symptoms reflect underlying histopathologic and biochemical events that must be reversed if treatment is to be effective.

[1]  Z. Ikezawa,et al.  New Horny Layer Marker Proteins for Evaluating Skin Condition in Atopic Dermatitis , 2009, International Archives of Allergy and Immunology.

[2]  M. Robinson Noninvasive Clinical Assessment of Skin Irritation/Inflammation , 2009 .

[3]  P. Parren,et al.  IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis1 , 2008, The Journal of Immunology.

[4]  T. E. Youket,et al.  Optimization of the skin multiple analyte profile bioanalytical method for determination of skin biomarkers from D‐Squame® tape samples , 2007, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[5]  M. Kleine,et al.  Barrier function, epidermal differentiation, and human beta-defensin 2 expression in tinea corporis. , 2007, The Journal of investigative dermatology.

[6]  P. Reygagne,et al.  Clobetasol propionate shampoo 0.05% in the treatment of seborrheic dermatitis of the scalp: results of a pilot study. , 2007, Cutis.

[7]  P. V. D. van de Kerkhof,et al.  Monitoring hyperproliferative disorders in human skin: Flow cytometry of changing cytokeratin expression , 2004, Cytometry. Part B, Clinical cytometry.

[8]  P. Zeeuwen Epidermal differentiation: the role of proteases and their inhibitors. , 2004, European journal of cell biology.

[9]  G. Bulmer,et al.  The antifungal action of dandruff shampoos , 2004, Mycopathologia.

[10]  E. Civila,et al.  The importance of microscopic examination in the management of desquamative diseases of the scalp , 2004, Mycopathologia.

[11]  C. Harding,et al.  Increased scalp skin lipids in response to antidandruff treatment containing zinc pyrithione , 2003, Archives of Dermatological Research.

[12]  M. Robinson,et al.  A non‐invasive tape absorption method for recovery of inflammatory mediators to differentiate normal from compromised scalp conditions , 2002, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[13]  C. Harding,et al.  Dandruff: a condition characterized by decreased levels of intercellular lipids in scalp stratum corneum and impaired barrier function , 2002, Archives of Dermatological Research.

[14]  E. Evans,et al.  Immunology of Diseases Associated with Malassezia Species , 2002, Clinical Microbiology Reviews.

[15]  R. Warner,et al.  Dandruff has an altered stratum corneum ultrastructure that is improved with zinc pyrithione shampoo. , 2001, Journal of the American Academy of Dermatology.

[16]  P. Elias,et al.  Pathogenesis of the permeability barrier abnormality in epidermolytic hyperkeratosis. , 2001, The Journal of investigative dermatology.

[17]  G. Piérard,et al.  Comparative Anti-Dandruff Efficacy between a Tar and a Non-Tar Shampoo , 2000, Dermatology.

[18]  P. Steinert,et al.  Bricks and mortar of the epidermal barrier , 1999, Experimental & Molecular Medicine.

[19]  J. Jensen,et al.  Expression of epidermal keratins and the cornified envelope protein involucrin is influenced by permeability barrier disruption. , 1998, The Journal of investigative dermatology.

[20]  P. Coulombe Towards a molecular definition of keratinocyte activation after acute injury to stratified epithelia. , 1997, Biochemical and biophysical research communications.

[21]  R. Hay,et al.  Dandruff and seborrhoeic dermatitis: causes and management , 1997, Clinical and experimental dermatology.

[22]  Rt M. KLICMaN,et al.  The Nature of Dandruff , 1976 .