TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults

[1]  Takao K Hensch,et al.  Trajectory of Parvalbumin Cell Impairment and Loss of Cortical Inhibition in Traumatic Brain Injury , 2017, Cerebral cortex.

[2]  U. Heinemann,et al.  Epileptiform activity and spreading depolarization in the blood–brain barrier-disrupted peri-infarct hippocampus are associated with impaired GABAergic inhibition and synaptic plasticity , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[3]  Marta Miquel,et al.  Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity , 2016, The Journal of Neuroscience.

[4]  D. Kaufer,et al.  A potential role for glia‐derived extracellular matrix remodeling in postinjury epilepsy , 2016, Journal of neuroscience research.

[5]  C. Moy,et al.  ALIAS (Albumin in Acute Ischemic Stroke) Trials: Analysis of the Combined Data From Parts 1 and 2 , 2016, Stroke.

[6]  U. Heinemann,et al.  Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin , 2016, Neurobiology of Disease.

[7]  Jing Ma,et al.  Losartan Attenuates Myocardial Endothelial-To-Mesenchymal Transition in Spontaneous Hypertensive Rats via Inhibiting TGF-β/Smad Signaling , 2016, PloS one.

[8]  H. Kitagawa,et al.  Involvement of chondroitin 6-sulfation in temporal lobe epilepsy , 2015, Experimental Neurology.

[9]  A. Simeone,et al.  Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons. , 2015, Cell reports.

[10]  B. Porter,et al.  Perineuronal net degradation in epilepsy , 2015, Epilepsia.

[11]  J. Huguenard,et al.  Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction , 2015, Neurobiology of Disease.

[12]  Matthew McMillin,et al.  TGFβ1 exacerbates blood–brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5 , 2015, Laboratory Investigation.

[13]  Arthur W. Toga,et al.  Blood-Brain Barrier Breakdown in the Aging Human Hippocampus , 2015, Neuron.

[14]  R. Guevara-Guzmán,et al.  Role of TGF-β signaling pathway on Tenascin C protein upregulation in a pilocarpine seizure model , 2014, Epilepsy Research.

[15]  Hua Yu,et al.  Revisiting STAT3 signalling in cancer: new and unexpected biological functions , 2014, Nature Reviews Cancer.

[16]  Arthur Brown,et al.  Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis , 2014, Neurobiology of Disease.

[17]  Egle Cekanaviciute,et al.  Astrocytic transforming growth factor‐beta signaling reduces subacute neuroinflammation after stroke in mice , 2014, Glia.

[18]  Phillip G. Popovich,et al.  Extracellular matrix regulation of inflammation in the healthy and injured spinal cord , 2014, Experimental Neurology.

[19]  U. Heinemann,et al.  Losartan prevents acquired epilepsy via TGF‐β signaling suppression , 2014, Annals of neurology.

[20]  G. K. Gray,et al.  NF-κB-Induced IL-6 Ensures STAT3 Activation and Tumor Aggressiveness in Glioblastoma , 2013, PloS one.

[21]  Simon Hametner,et al.  Iron and neurodegeneration in the multiple sclerosis brain , 2013, Annals of neurology.

[22]  T. Hensch,et al.  Perineuronal nets protect fast-spiking interneurons against oxidative stress , 2013, Proceedings of the National Academy of Sciences.

[23]  A. Faissner,et al.  Primary Hippocampal Neurons, Which Lack Four Crucial Extracellular Matrix Molecules, Display Abnormalities of Synaptic Structure and Function and Severe Deficits in Perineuronal Net Formation , 2013, The Journal of Neuroscience.

[24]  Mario Cammarota,et al.  Fast spiking interneuron control of seizure propagation in a cortical slice model of focal epilepsy , 2013, The Journal of physiology.

[25]  A. Friedman,et al.  Peri-infarct blood–brain barrier dysfunction facilitates induction of spreading depolarization associated with epileptiform discharges , 2012, Neurobiology of Disease.

[26]  D. Kaufer,et al.  Blood–brain barrier dysfunction–induced inflammatory signaling in brain pathology and epileptogenesis , 2012, Epilepsia.

[27]  A. Hata,et al.  Targeting the TGFβ signalling pathway in disease , 2012, Nature Reviews Drug Discovery.

[28]  Mansher Singh,et al.  Modulation of Transforming Growth Factor-&bgr; Signaling and Extracellular Matrix Production in Myxomatous Mitral Valves by Angiotensin II Receptor Blockers , 2012, Circulation.

[29]  A. Prochiantz,et al.  Otx2 Binding to Perineuronal Nets Persistently Regulates Plasticity in the Mature Visual Cortex , 2012, The Journal of Neuroscience.

[30]  M. de Curtis,et al.  Seizure‐induced brain‐borne inflammation sustains seizure recurrence and blood–brain barrier damage , 2012, Annals of neurology.

[31]  Yunyong Ma,et al.  Functional alterations in GABAergic fast-spiking interneurons in chronically injured epileptogenic neocortex , 2012, Neurobiology of Disease.

[32]  H. Hartung,et al.  Macrophages prevent hemorrhagic infarct transformation in murine stroke models , 2012, Annals of neurology.

[33]  Edward O. Mann,et al.  Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model , 2012, Cell.

[34]  C. Elger,et al.  Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions , 2012, Epilepsia.

[35]  D. Centonze,et al.  Impaired striatal GABA transmission in experimental autoimmune encephalomyelitis , 2011, Brain, Behavior, and Immunity.

[36]  Xiaoming Jin,et al.  Reorganization of inhibitory synaptic circuits in rodent chronically injured epileptogenic neocortex. , 2011, Cerebral cortex.

[37]  A. Buchan,et al.  Neurological complications of acute ischaemic stroke , 2011, The Lancet Neurology.

[38]  Markus Schuelke,et al.  Gamma oscillations in the hippocampus require high complex I gene expression and strong functional performance of mitochondria. , 2011, Brain : a journal of neurology.

[39]  Melitta Schachner,et al.  Compartmentalization from the outside: the extracellular matrix and functional microdomains in the brain , 2010, Trends in Neurosciences.

[40]  L. Sorokin The impact of the extracellular matrix on inflammation , 2010, Nature Reviews Immunology.

[41]  Alon Friedman,et al.  Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury , 2010, Nature Reviews Neurology.

[42]  C. Glass,et al.  Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. , 2010, Molecular cell.

[43]  C. Schachtrup,et al.  Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-β after Vascular Damage , 2010, The Journal of Neuroscience.

[44]  I. Fried,et al.  Epileptogenic temporal cavernous malformations: Operative strategies and postoperative seizure outcomes , 2010, Seizure.

[45]  M. Shapira,et al.  Transcriptome Profiling Reveals TGF-β Signaling Involvement in Epileptogenesis , 2009, The Journal of Neuroscience.

[46]  A. Prochiantz,et al.  Experience-Dependent Transfer of Otx2 Homeoprotein into the Visual Cortex Activates Postnatal Plasticity , 2008, Cell.

[47]  Jun Tan,et al.  Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology , 2008, Nature Medicine.

[48]  L. Kaczmarek,et al.  Important role of matrix metalloproteinase 9 in epileptogenesis , 2008, The Journal of cell biology.

[49]  B. Zlokovic The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders , 2008, Neuron.

[50]  C. Elger,et al.  Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy , 2007, Neurology.

[51]  D. Judge,et al.  Angiotensin II type 1 receptor blockade attenuates TGF-β–induced failure of muscle regeneration in multiple myopathic states , 2007, Nature Medicine.

[52]  Alon Friedman,et al.  TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. , 2007, Brain : a journal of neurology.

[53]  T. Hensch Critical period plasticity in local cortical circuits , 2005, Nature Reviews Neuroscience.

[54]  S. Prime,et al.  Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF‐β1 involves MAPK, Smad and AP‐1 signalling pathways , 2005, Journal of cellular biochemistry.

[55]  Jens P Dreier,et al.  Lasting Blood-Brain Barrier Disruption Induces Epileptic Focus in the Rat Somatosensory Cortex , 2004, The Journal of Neuroscience.

[56]  P. Brown,et al.  Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[57]  A. Schulze-Bonhage,et al.  CD34-immunoreactive balloon cells in cortical malformations , 2004, Acta Neuropathologica.

[58]  A. Bringmann,et al.  Diffuse perineuronal nets and modified pyramidal cells immunoreactive for glutamate and the GABAA receptor α1 subunit form a unique entity in rat cerebral cortex , 2003, Experimental Neurology.

[59]  S. Mori,et al.  Kainic acid-induced convulsions cause prolonged changes in the chondroitin sulfate proteoglycans neurocan and phosphacan in the limbic structures , 2003, Experimental Neurology.

[60]  V. Sementchenko,et al.  Ets1 Is an Effector of the Transforming Growth Factor β (TGF-β) Signaling Pathway and an Antagonist of the Profibrotic Effects of TGF-β* , 2002, The Journal of Biological Chemistry.

[61]  M. Joyce,et al.  Annexin 1: a new paracrine agent secreted by a novel mechanism , 2002, Journal of anatomy.

[62]  M. Karin,et al.  Signal transduction by tumor necrosis factor and its relatives. , 2001, Trends in cell biology.

[63]  J. Avruch,et al.  Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. , 2001, Physiological reviews.

[64]  R. Busto,et al.  Human Albumin Therapy of Acute Ischemic Stroke: Marked Neuroprotective Efficacy at Moderate Doses and With a Broad Therapeutic Window , 2001, Stroke.

[65]  J. Fawcett,et al.  Neurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes , 2000, The Journal of Neuroscience.

[66]  I. Stamenkovic,et al.  Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. , 2000, Genes & development.

[67]  P. Pattany,et al.  Diffusion-weighted magnetic resonance imaging confirms marked neuroprotective efficacy of albumin therapy in focal cerebral ischemia. , 1998, Stroke.

[68]  M. Frotscher,et al.  Up-regulation of astrocyte-derived tenascin-C correlates with neurite outgrowth in the rat dentate gyrus after unilateral entorhinal cortex lesion , 1997, Neuroscience.

[69]  G. Buzsáki,et al.  Temporal structure in spatially organized neuronal ensembles: a role for interneuronal networks , 1995, Current Opinion in Neurobiology.

[70]  L. Mucke,et al.  Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1. , 1995, The American journal of pathology.

[71]  J R Wolff,et al.  Perineuronal nets provide a polyanionic, glia‐associated form of microenvironment around certain neurons in many parts of the rat brain , 1993, Glia.

[72]  J. Prehn,et al.  Transforming Growth Factor-β1 Prevents Glutamate Neurotoxicity in Rat Neocortical Cultures and Protects Mouse Neocortex from Ischemic Injury in vivo , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[73]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[74]  V. Sementchenko,et al.  Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta. , 2002, The Journal of biological chemistry.

[75]  Inder M Verma,et al.  NF-kappaB regulation in the immune system. , 2002, Nature reviews. Immunology.