Nedd4‐1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function
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B. Ciruna | F. Sicheri | P. Dirks | D. Rotin | I. Clarke | S. Guettler | P. Alberts | Avinash K. Persaud | M. Hayes
[1] D. Rotin,et al. Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease , 2011, Proceedings of the National Academy of Sciences.
[2] M. Brand,et al. Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking , 2011, Nature Cell Biology.
[3] S. Ota,et al. FGF receptor gene expression and its regulation by FGF signaling during early zebrafish development , 2010, Genesis.
[4] R. Flavell,et al. Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling. , 2010, Cancer cell.
[5] S. Gygi,et al. Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor , 2010, The Journal of cell biology.
[6] Christian Rosenmund,et al. Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development , 2010, Neuron.
[7] N. Turner,et al. Fibroblast growth factor signalling: from development to cancer , 2010, Nature Reviews Cancer.
[8] B. Bruneau,et al. The Ubiquitin Ligase Nedd4-1 Is Required for Heart Development and Is a Suppressor of Thrombospondin-1* , 2009, The Journal of Biological Chemistry.
[9] John Parkinson,et al. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays , 2009, Molecular systems biology.
[10] R. Russell,et al. Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. , 2009, Cell stem cell.
[11] D. Rotin,et al. Physiological functions of the HECT family of ubiquitin ligases , 2009, Nature Reviews Molecular Cell Biology.
[12] R. Oppenheim,et al. Abnormal development of the neuromuscular junction in Nedd4-deficient mice. , 2009, Developmental biology.
[13] P. Marrack,et al. Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells , 2008, Nature Immunology.
[14] David R. Croucher,et al. Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling , 2008, Science Signaling.
[15] J. Stokes,et al. Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. , 2008, American journal of physiology. Renal physiology.
[16] J. Wesche,et al. Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis. , 2008, Molecular biology of the cell.
[17] G. Parkin,et al. Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture , 2008, Molecular and Cellular Neuroscience.
[18] Chunaram Choudhary,et al. Flt3-dependent transformation by inactivating c-Cbl mutations in AML. , 2007, Blood.
[19] D. Rotin,et al. Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination , 2006, The Journal of cell biology.
[20] F. Lee,et al. Cell Survival through Trk Neurotrophin Receptors Is Differentially Regulated by Ubiquitination , 2006, Neuron.
[21] J. Forman-Kay,et al. Structural determinants for high-affinity binding in a Nedd4 WW3* domain-Comm PY motif complex. , 2006, Structure.
[22] Austin G Smith,et al. Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell , 2005, PLoS biology.
[23] V. P. Eswarakumar,et al. Cellular signaling by fibroblast growth factor receptors. , 2005, Cytokine & growth factor reviews.
[24] H. Stenmark,et al. Defective downregulation of receptor tyrosine kinases in cancer , 2004, The EMBO journal.
[25] S. Scholpp,et al. Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary , 2004, Development Genes and Evolution.
[26] Y. Yarden,et al. Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases , 2004, Oncogene.
[27] Wolfgang Wurst,et al. The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum , 2003, Development.
[28] A. Vecchione,et al. The Grb10/Nedd4 Complex Regulates Ligand-Induced Ubiquitination and Stability of the Insulin-Like Growth Factor I Receptor , 2003, Molecular and Cellular Biology.
[29] Wolfgang Wurst,et al. FGFR1 is independently required in both developing mid‐ and hindbrain for sustained response to isthmic signals , 2003, The EMBO journal.
[30] I. Lax,et al. FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[31] Pier Paolo Di Fiore,et al. A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins , 2002, Nature.
[32] I. Dikic,et al. Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptors , 2002, Nature.
[33] D. Rotin,et al. Nedd4 Regulates Ubiquitination and Stability of the Guanine-Nucleotide Exchange Factor CNrasGEF* , 2001, The Journal of Biological Chemistry.
[34] H. Band,et al. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. , 2001, Molecular cell.
[35] P. Snyder,et al. Multiple WW Domains, but Not the C2 Domain, Are Required for Inhibition of the Epithelial Na+ Channel by Human Nedd4* , 2001, The Journal of Biological Chemistry.
[36] J. Forman-Kay,et al. Solution structure of a Nedd4 WW domain–ENaC peptide complex , 2001, Nature Structural Biology.
[37] A. Vandewalle,et al. A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[38] J. Schlessinger. Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.
[39] K. Losos,et al. FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. , 1999, Development.
[40] Y. Yarden,et al. The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor* , 1999, The Journal of Biological Chemistry.
[41] I. Cobos,et al. FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. , 1999, Development.
[42] L. Schild,et al. Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome. , 1999, The Journal of clinical investigation.
[43] H. Yeger,et al. The C2 Domain of the Ubiquitin Protein Ligase Nedd4 Mediates Ca2+-dependent Plasma Membrane Localization* , 1997, The Journal of Biological Chemistry.
[44] M. Fürthauer,et al. A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula. , 1997, Development.
[45] Joseph Schlessinger,et al. Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism , 1996, Cell.
[46] O. Staub,et al. WW domains of Nedd4 bind to the proline‐rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. , 1996, The EMBO journal.
[47] R. Harland,et al. Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern. , 1995, Development.
[48] M. Mishina,et al. Differential expression of two zebrafish emx homeoprotein mRNAs in the developing brain , 1995, Neuroscience Letters.
[49] R. Patient,et al. Analysis of FGF function in normal and no tail zebrafish embryos reveals separate mechanisms for formation of the trunk and the tail. , 1995, Development.
[50] J. Schlessinger,et al. Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766. , 1994, The Journal of biological chemistry.
[51] E. Oxtoby,et al. Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development. , 1993, Nucleic acids research.
[52] M. Jaye,et al. A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1 , 1991, Molecular and cellular biology.
[53] Terje Johansen,et al. Expression pattern of zebrafish pax genes suggests a role in early brain regionalization , 1991, Nature.
[54] V. Fried,et al. Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor. , 1989, Science.
[55] S. Ota,et al. The roles of the FGF signal in zebrafish embryos analyzed using constitutive activation and dominant-negative suppression of different FGF receptors , 2009, Mechanisms of Development.
[56] I. Cobos,et al. FGF 8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx 2 expression , 1999 .