A solid-state electrochemical sensing platform based on a supramolecular hydrogel

Abstract Supramolecular hydrogels formed from the biopolymer chitosan and zinc ions were used as disposable electrochemical sensing platforms for the determination of hydroxyl radicals and hydrogen peroxide for the first time. The enclosed chitosan hydrogel served as the electrolyte for the system. In the presence of hydroxyl radicals or hydrogen peroxide, the chitosan hydrogel underwent depolymerization, resulting in the release of zinc ions from complexes formed with the hydrogel. The changes in the current from the zinc ions were then monitored and used as a signal for determining the concentration of analyte. The proposed chitosan hydrogel sensing platform exhibited a comparable detection performance with wide linear ranges and low detection limits for the two analytes. The linear detection range could be further manipulated by varying the depolymerization time. Due to the low cost and simplicity of the preparation process, this enzyme- and DNA-free sensing platform possesses great potential for application in disposable point-of-care devices and in-field testing. Additionally, the application of the proposed chitosan hydrogel to antioxidant screening could be further explored.

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