Application of multiple inversion recovery for suppression of macromolecule resonances in short echo time (1)H NMR spectroscopy of human brain.

Macromolecules contribute broad "background" resonances to the (1)H NMR brain spectra at short echo times. The application of long echo times is the most widely used method for removing these resonances. Here, it is demonstrated that these background resonances may be suppressed at short echo times using multiple inversion recovery (MIR). In the technique presented, the MIR sequence consists of four adiabatic inversion pulses, applied preparatory to a 20-ms echo time stimulated echo localization sequence. The inversion times (359, 157, 69, and 20 ms) were selected to preferentially suppress macromolecules with longitudinal relaxation times between 38 and 300 ms. While the resulting spectra have lower overall signal-to-noise, baseline contributions from macromolecules are greatly reduced. Unlike the typical long TE acquisitions, the short TE MIR acquisition preserves the myo-inositol resonance.

[1]  A A Bankier,et al.  Double inversion recovery imaging of the brain: initial experience and comparison with fluid attenuated inversion recovery imaging. , 1998, Magnetic resonance imaging.

[2]  Jens Frahm,et al.  Localized proton MRS of the human hippocampus: Metabolite concentrations and relaxation times , 1999, Magnetic resonance in medicine.

[3]  O Henriksen,et al.  In vivo quantification of brain metabolites by 1H-MRS using water as an internal standard. , 1993, Magnetic resonance imaging.

[4]  H. Larsson,et al.  The concentration of N-acetyl aspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium. , 1993, Magnetic resonance imaging.

[5]  B D Ross,et al.  Absolute Quantitation of Water and Metabolites in the Human Brain. I. Compartments and Water , 1993 .

[6]  R. B. Kingsley,et al.  WET, a T1- and B1-insensitive water-suppression method for in vivo localized 1H NMR spectroscopy. , 1994, Journal of magnetic resonance. Series B.

[7]  Chrit T. W. Moonen,et al.  Highly Effective Water Suppression for in vivo proton NMR Spectroscopy (DRYSTEAM) , 1990 .

[8]  J. Saunders,et al.  Double inversion recovery improves water suppression in vivo , 1993, Magnetic resonance in medicine.

[9]  R. Kimmich,et al.  Volume-selective multipulse spin-echo spectroscopy , 1987 .

[10]  T W Redpath,et al.  Technical note: use of a double inversion recovery pulse sequence to image selectively grey or white brain matter. , 1994, The British journal of radiology.

[11]  Joseph Granot,et al.  Selected Volume Excitation Using Stimulated Echoes (VEST). Applications to spatially localized spectroscopy and imaging , 1986 .

[12]  K. Behar,et al.  Analysis of macromolecule resonances in 1H NMR spectra of human brain , 1994, Magnetic resonance in medicine.

[13]  P A Narayana,et al.  In vivo proton magnetic resonance spectroscopy studies of human brain. , 1991, Magnetic resonance imaging.

[14]  J. Frahm,et al.  Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentrations of cerebral metabolites , 1989, Magnetic resonance in medicine.

[15]  P. Bottomley.  Spatial Localization in NMR Spectroscopy in Vivo , 1987, Annals of the New York Academy of Sciences.

[16]  T. Ernst,et al.  Improved water suppression for localized in vivo 1H spectroscopy. , 1995, Journal of magnetic resonance. Series B.

[17]  O. Henriksen,et al.  Reduced N-acetylaspartate content in the frontal part of the brain in patients with probable Alzheimer's disease. , 1995, Magnetic resonance imaging.

[18]  Jens Frahm,et al.  Localized proton spectroscopy using stimulated echoes. , 1987 .

[19]  G P Stomp,et al.  Multiple inversion recovery reduces static tissue signal in angiograms , 1991, Magnetic resonance in medicine.

[20]  Effect of long TE on T1 measurement in STEAM progressive saturation experiment. , 1997, Journal of magnetic resonance.

[21]  Takashi Ogino,et al.  Characterization of macromolecule resonances in the 1H NMR spectrum of rat brain , 1993, Magnetic resonance in medicine.

[22]  V. Mai,et al.  Improved visualization of the human lung in 1H MRI using multiple inversion recovery for simultaneous suppression of signal contributions from fat and muscle , 1999, Magnetic resonance in medicine.

[23]  P. Tofts,et al.  A critical assessment of methods of measuring metabolite concentrations by NMR spectroscopy , 1988, NMR in biomedicine.

[24]  J H Duyn,et al.  Multisection proton MR spectroscopic imaging of the brain. , 1993, Radiology.

[25]  A Horsman,et al.  Determination of proton metabolite concentrations and relaxation parameters in normal human brain and intracranial tumours , 1995, NMR in biomedicine.