1. BIOMATH, Department of Mathematical Modelling, Statistics and Bioinformatics, Faculty of Bioscience Engineering, Ghent University, Belgium 2. Laboratory of Pharmaceutical Process Analytical Technology, Department of Pharmaceutical Analysis, Ghent University, Belgium 3. School of Pharmacy, University of Eastern Finland, Finland 4. Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Ghent University, Belgium 5. Optical Measurement Technologies, VTT Technical Research Centre, Finland 6. CAPEC-PROCESS, Department of Chemical and Biochemical Engineering, Technical University of Denmark, Denmark Email: Ingmar.Nopens@UGent.be, *Shared last authorship