One‐year follow‐up of young children hospitalized for wheezing: the influence of early anti‐inflammatory therapy and risk factors for subsequent wheezing and asthma

We investigated the 1‐year outcome of children hospitalized for wheezing, paying special attention to the effect of early anti‐inflammatory therapy. In addition, we identified risk factors for recurrent wheezing and asthma. Eighty‐eight children under 2 years old treated in the hospital for wheezing were followed for 1 year. Nebulized anti‐inflammatory therapy was given for 16 weeks: 31 patients received budesonide, 29 patients cromolyn sodium, and 28 control patients received no therapy. The number of subsequent physician‐diagnosed wheezing episodes was recorded.

[1]  K. Savolainen,et al.  Nasopharyngeal eosinophil cationic protein in bronchiolitis , 1997, Pediatric pulmonology.

[2]  M Korppi,et al.  Serum eosinophil cationic protein as a predictor of wheezing after bronchiolitis , 1997, Pediatric pulmonology.

[3]  C. Delacourt,et al.  Efficacy of nebulized budesonide in treatment of severe infantile asthma: a double-blind study. , 1996, The Journal of allergy and clinical immunology.

[4]  M. Korppi,et al.  Anti-inflammatory therapy reduces wheezing after bronchiolitis. , 1996, Archives of pediatrics & adolescent medicine.

[5]  M. Wickman,et al.  Indoor environmental risk factors in young asthmatics: a case-control study. , 1995, Archives of disease in childhood.

[6]  M. Korppi,et al.  The clinical efficacy of nebulized racemic epinephrine and albuterol in acute bronchiolitis. , 1995, Archives of pediatrics & adolescent medicine.

[7]  F. Martinez,et al.  Viral infections and the development of asthma. , 1995, American journal of respiratory and critical care medicine.

[8]  B. Björkstén,et al.  Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls. , 1995, Pediatrics.

[9]  W. Morgan,et al.  Asthma and wheezing in the first six years of life. The Group Health Medical Associates. , 1995, The New England journal of medicine.

[10]  L I Landau,et al.  Lung function, airway responsiveness, and respiratory symptoms before and after bronchiolitis. , 1995, Archives of disease in childhood.

[11]  M. Korppi,et al.  Bronchial asthma and hyperreactivity after early childhood bronchiolitis or pneumonia. An 8-year follow-up study. , 1994, Archives of pediatrics & adolescent medicine.

[12]  S. H. Arshad,et al.  The effect of genetic and environmental factors on the prevalence of allergic disorders at the age of two years , 1993, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[13]  M. Korppi,et al.  A 2- to 3-year outcome after bronchiolitis. , 1993, American journal of diseases of children.

[14]  W. Morgan,et al.  Child day care, smoking by caregivers, and lower respiratory tract illness in the first 3 years of life. Group Health Medical Associates. , 1993, Pediatrics.

[15]  W. Morgan,et al.  Risk factors for developing wheezing and asthma in childhood. , 1992, Pediatric clinics of North America.

[16]  C. O’Callaghan,et al.  Respiratory status and allergy after bronchiolitis. , 1992, Archives of disease in childhood.

[17]  G. Wennergren,et al.  Characteristics and prognosis of hospital‐treated obstructive bronchitis in children aged less than two years , 1992, Acta paediatrica.

[18]  S. Stick,et al.  Bronchial responsiveness and lung function in recurrently wheezy infants. , 1991, The American review of respiratory disease.

[19]  S. Halken,et al.  Recurrent wheezing in relation to environmental risk factors in infancy , 1991, Allergy.

[20]  P. Venge,et al.  Radioimmunoassay of human eosinophil cationic protein (ECP) by an improved method. Establishment of normal levels in serum and turnover in vivo , 1991, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[21]  T. Klassen,et al.  Randomized trial of salbutamol in acute bronchiolitis. , 1991, The Journal of pediatrics.

[22]  H. Levison,et al.  Nebulized albuterol in acute bronchiolitis. , 1990, The Journal of pediatrics.

[23]  K. Carlsen,et al.  Nebulised beclomethasone dipropionate in recurrent obstructive episodes after acute bronchiolitis. , 1988, Archives of disease in childhood.

[24]  W. Morgan,et al.  Diminished lung function as a predisposing factor for wheezing respiratory illness in infants. , 1988, The New England journal of medicine.

[25]  F. Martinez,et al.  Parental smoking enhances bronchial responsiveness in nine-year-old children. , 1988, The American review of respiratory disease.

[26]  G. M. Stokes,et al.  Respiratory problems 2 years after acute bronchiolitis in infancy. , 1983, Archives of disease in childhood.

[27]  E. Hey,et al.  Underdiagnosis and undertreatment of asthma in childhood. , 1983, British medical journal.

[28]  M. Kajosaari,et al.  SERUM IMMUNOGLOBULIN E IN ATOPIC AND NON‐ATOPIC CHILDREN AGED 6 MONTHS TO 5 YEARS , 1982, Acta paediatrica Scandinavica.

[29]  P. Phelan,et al.  Respiratory Illness in Children , 1975 .

[30]  B. Zweiman,et al.  The relationship between bronchiolitis and allergic asthma. A prospective study with allergy evaluation. , 1966, The Journal of allergy.