MmtDB: a Metazoa mitochondrial DNA variants database

The present paper describes the structure of MmtDB-a specialized database designed to collect Metazoa mitochondrial DNA variants. Priority in the data collection is given to the Metazoa species for which a large amount of variants is available, as it is the case for human variants. Starting from the sequences available in the Nucleotide Sequence Databases, the redundant sequences are removed and new sequences from other sources are added. Value-added information are associated to each variant sequence, e.g. analysed region, experimental method, tissue and cell lines, population data, sex, age, family code and information about the variation events (nucleotide position, involved gene, restriction site's gain or loss). Cross-references are introduced to the EMBL Data Library, as well as an internal cross-referencing among MmtDB entries according to their tissual, heteroplasmic, familiar and aplotypical correlation. MmtDB can be accessed through the World Wide Web at URL [see text].

[1]  J. Wrigglesworth,et al.  Achievements and perspectives of mitochondrial research , 1987 .

[2]  K. Hawkes,et al.  African populations and the evolution of human mitochondrial DNA. , 1991, Science.

[3]  M. Stoneking,et al.  Geographic variation in human mitochondrial DNA from Papua New Guinea. , 1990, Genetics.

[4]  D. Wallace.  Mitochondrial genetics: a paradigm for aging and degenerative diseases? , 1992, Science.

[5]  M. M. Nass,et al.  INTRAMITOCHONDRIAL FIBERS WITH DNA CHARACTERISTICS: I. Fixation and Electron Staining Reactions , 1963 .

[6]  C Saccone,et al.  The evolution of mitochondrial DNA. , 1994, Current opinion in genetics & development.

[7]  A. Torroni,et al.  Mitochondrial DNA variation in human populations and implications for detection of mitochondrial DNA mutations of pathological significance , 1994, Journal of bioenergetics and biomembranes.

[8]  D. Wolstenholme,et al.  Animal mitochondrial DNA: structure and evolution. , 1992, International review of cytology.

[9]  Timothy G. Littlejohn,et al.  The Organelle Genome Database Project (GOBASE) , 1998, Nucleic Acids Res..

[10]  S. Pääbo,et al.  Extensive mitochondrial diversity within a single Amerindian tribe. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[11]  W. Hauswirth,et al.  Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[12]  H. Cann,et al.  Maternal inheritance of human mitochondrial DNA. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[13]  B. Bainbridge,et al.  Genetics , 1981, Experientia.

[14]  M. Stoneking,et al.  Mitochondrial DNA and human evolution , 1987, Nature.

[15]  D. Wallace.  Mitotic segregation of mitochondrial dnas in human cell hybrids and expression of chloramphenicol resistance , 1986, Somatic cell and molecular genetics.

[16]  Shamkant B. Navathe,et al.  MITOMAP: a human mitochondrial genome database--1998 update , 1998, Nucleic Acids Res..

[17]  J. Devereux,et al.  A comprehensive set of sequence analysis programs for the VAX , 1984, Nucleic Acids Res..

[18]  Merritt Ruhlen,et al.  A Guide to the World''s Languages: Volume 1 , 1987 .

[19]  Mwj Cleeter,et al.  Achievements and perspectives of mitochondrial research , 1985 .

[20]  F. Sanger,et al.  Sequence and organization of the human mitochondrial genome , 1981, Nature.