Detection of asymptomatic celiac disease in two siblings from a mother with non-celiac gluten sensitivity

Non-celiac gluten sensitivity and celiac disease are known to be two distinct clinical entities, however, non-celiac gluten sensitivity has been detected in a proportion of first-degree relatives of celiac patients. Herein for the first time we describe the occurrence of asymptomatic celiac disease in two siblings, a girl and a boy, whose mother suffered from a proven non-celiac gluten sensitivity. Both the 12-year old girl and 9-year old boy were positive for anti-endomysial and anti-tissue transglutaminase antibodies of IgA class at a very high and low titer, respectively. Duodenal biopsy confirmed the diagnosis of active celiac disease (severe villous flattening) in the girl, whereas her brother had Marsh 1 lesion consistent with a potential celiac disease. This case report indicates that antibody screening for celiac disease can be recommended in any symptomatic or asymptomatic first-degree relatives of patients with non-celiac gluten sensitivity.

[1]  D. Schuppan,et al.  The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update , 2017, Nutrients.

[2]  R. De Giorgio,et al.  Non-coeliac gluten/wheat sensitivity: advances in knowledge and relevant questions , 2017, Expert review of gastroenterology & hepatology.

[3]  R. De Giorgio,et al.  Features and Progression of Potential Celiac Disease in Adults. , 2016, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[4]  G. Corazza,et al.  Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial. , 2015, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[5]  D. Sanders,et al.  Systematic review: noncoeliac gluten sensitivity , 2015, Alimentary pharmacology & therapeutics.

[6]  K. Rostami,et al.  Mucosal histopathology in celiac disease: a rebuttal of Oberhuber’s sub-division of Marsh III , 2015, Gastroenterology and hepatology from bed to bench.

[7]  R. De Giorgio,et al.  The changing clinical profile of celiac disease: a 15-year experience (1998-2012) in an Italian referral center , 2014, BMC Gastroenterology.

[8]  G. Corazza,et al.  An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity , 2014, BMC Medicine.

[9]  D. Leffler,et al.  Celiac Disease or Non-Celiac Gluten Sensitivity? An Approach to Clinical Differential Diagnosis , 2014, The American Journal of Gastroenterology.

[10]  D. Sanders,et al.  A UK study assessing the population prevalence of self-reported gluten sensitivity and referral characteristics to secondary care , 2014, European journal of gastroenterology & hepatology.

[11]  M. Soresi,et al.  Non-Celiac Wheat Sensitivity Diagnosed by Double-Blind Placebo-Controlled Challenge: Exploring a New Clinical Entity , 2012, The American Journal of Gastroenterology.

[12]  G. Caio,et al.  Coeliac disease: changing diagnostic criteria? , 2012, Gastroenterology and hepatology from bed to bench.

[13]  R. Giorgio,et al.  New understanding of gluten sensitivity , 2012, Nature Reviews Gastroenterology &Hepatology.

[14]  Peter HR Green,et al.  Spectrum of gluten-related disorders: consensus on new nomenclature and classification , 2012, BMC Medicine.

[15]  L. Greco,et al.  Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease. , 1999, Gastroenterology.