Preparation and Physicochemical Characterization of Acid Modified Cassava Starch and Its Evaluation as Directly Compressible Tablet Excipient

®were produced with acceptable tablet characteristics (a minimum of 50 N crushing strength and < 1% friability) up to 0.75% and at 0.25% magnesium stearate concentrations, respectively. The spray dried AMCS was able to accommodate up to 40% paracetamol by weight with crushing strength of 55.90 ± 2.84 N and friability of 0.80 ± 0.06%. Starch 1500 ® tablets were more friable and exhibited lower crushing strengths at all paracetamol concentrations as compared to the spray dried AMCS tablets (P < 0.05). The dilution potential and lubricant sensitivity of the spray-dried AMCS were significantly higher than those of spray dried NCS and Starch 1500 ® . Hence, spray dried AMCS has the potential for application as a directly compressible tablet excipient.

[1]  N. Armstrong.  Tablet Manufacture by Direct Compression , 2013 .

[2]  I. Rashid,et al.  Characterization of the impact of magnesium stearate lubrication on the tableting properties of chitin-Mg silicate as a superdisintegrating binder when compared to Avicel® 200 , 2010 .

[3]  K. Picker-Freyer,et al.  Characterization of acid modified Dioscorea starches as direct compression excipient , 2009, Pharmaceutical development and technology.

[4]  Gregory E. Amidon,et al.  Particle, Powder, and Compact Characterization , 2009 .

[5]  I. Demiate,et al.  Effect of acid-methanol treatment on the physicochemical and structural characteristics of cassava and maize starches , 2008 .

[6]  O. Itiola,et al.  Comparative Evaluation of the Binding Properties of Two Species of Khaya Gum Polymer in a Paracetamol Tablet Formulation , 2008 .

[7]  N. Sutanthavibul,et al.  Spherical composite particles of rice starch and microcrystalline cellulose: A new coprocessed excipient for direct compression , 2004, AAPS PharmSciTech.

[8]  R. Beck,et al.  Effects of Filler-Binders and Lubricants on Physicochemical Properties of Tablets Obtained by Direct Compression: A 2 2 Factorial Design , 2008 .

[9]  Yolima Baena,et al.  Physicochemical Characterization and Application of Yam (Dioscorea cayenensis‐rotundata) Starch as a Pharmaceutical Excipient , 2007 .

[10]  Jaspreet Singh,et al.  Factors influencing the physico-chemical, morphological, thermal and rheological properties of some chemically modified starches for food applications--A review , 2007 .

[11]  A. Ekiti,et al.  Investigation on modification of cassava starch using active components of ginger roots (Zingiber officinale Roscoe) , 2006 .

[12]  M. Lanz.  Pharmaceutical powder technology : towards a science based understanding of the behavior of powder systems , 2006 .

[13]  A. Shukla,et al.  Evaluation of Preflo® Modified Starches as New Direct Compression Excipients. I. Tabletting Characteristics , 1993, Pharmaceutical Research.

[14]  Arvind K. Bansal,et al.  Coprocessed excipients for solid dosage forms , 2004 .

[15]  W. Bergthaller,et al.  Characterization and Utilization of Acid‐modified Rice Starches for Use in Pharmaceutical Tablet Compression , 2003 .

[16]  Saiyavit Varavinit,et al.  Characterization and utilization of acid-modified cross-linked Tapioca starch in pharmaceutical tablets , 2003 .

[17]  S. N. Moorthy.  Physicochemical and Functional Properties of Tropical Tuber Starches: A Review , 2002 .

[18]  G. Alebiowu,et al.  Compressional Characteristics of Native and Pregelatinized Forms of Sorghum, Plantain, and Corn Starches and the Mechanical Properties of Their Tablets , 2002, Drug development and industrial pharmacy.

[19]  R. Ferris,et al.  Marketing opportunities for starch and high quality flour production from cassava and sweetpotato in Uganda: RCMP research monograph, No. 29 , 2002 .

[20]  Mukesh C. Gohel,et al.  Functionality testing of a multifunctional directly compressible adjuvant containing lactose, polyvinylpyrrolidone, and croscarmellose sodium , 2002 .

[21]  P. Chinachoti,et al.  A study of some physicochemical properties of high-crystalline tapioca starch , 2001 .

[22]  Klanarong Sriroth,et al.  Cassava Starch Technology: The Thai Experience , 2000 .

[23]  Saiyavit Varavinit,et al.  Morphological Properties of Acid-modified Tapioca Starch , 2000 .

[24]  G. Bolhuis,et al.  Effect of magnesium stearate on bonding and porosity expansion of tablets produced from materials with different consolidation properties. , 1999, International journal of pharmaceutics.

[25]  Jain,et al.  Mechanical properties of powders for compaction and tableting: an overview. , 1999, Pharmaceutical science & technology today.

[26]  E. S. Ghaly,et al.  Evaluation of two dextrose-based directly compressible excipients. , 1998, Drug development and industrial pharmacy.

[27]  M. Perales,et al.  Comparative Tableting and Microstructural Properties of a New Starch for Direct Compression , 1996 .

[28]  L. E. Morris,et al.  Characterization and Performance of a New Direct Compression Excipient for Chewable Tablets: Xylitab® , 1996 .

[29]  P. Schmidt,et al.  Isolation and Physico‐chemical Properties of Enset Starch , 1996 .

[30]  E. Gbur,et al.  Comparison of two models to predict amylose concentration in rice flours as determined by spectrophotometric assay , 1991 .

[31]  E. L. Parrott.  Comparative Evaluation of A New Direct Compression Excipient, Soludex™ 15 , 1989 .

[32]  G S Banker,et al.  Determination of porosity and pore-size distribution of aspirin tablets relevant to drug stability. , 1977, Journal of pharmaceutical sciences.