Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy

[1]  J. K. Leach,et al.  Increased Survival and Function of Mesenchymal Stem Cell Spheroids Entrapped in Instructive Alginate Hydrogels , 2016, Stem cells translational medicine.

[2]  David J. Mooney,et al.  Biomaterials and emerging anticancer therapeutics: engineering the microenvironment , 2015, Nature Reviews Cancer.

[3]  B. Newland,et al.  Tackling Cell Transplantation Anoikis: An Injectable, Shape Memory Cryogel Microcarrier Platform Material for Stem Cell and Neuronal Cell Growth. , 2015, Small.

[4]  G. Ehninger,et al.  Bispecific antibody releasing-mesenchymal stromal cell machinery for retargeting T cells towards acute myeloid leukemia blasts , 2015, Blood Cancer Journal.

[5]  D. Mooney,et al.  Engineered Materials for Cancer Immunotherapy. , 2015, Nano today.

[6]  J. Steinbach,et al.  (18)F-Labeled 1,4-Dioxa-8-azaspiro[4.5]decane Derivative: Synthesis and Biological Evaluation of a σ1 Receptor Radioligand with Low Lipophilicity as Potent Tumor Imaging Agent. , 2015, Journal of medicinal chemistry.

[7]  J. Tabernero,et al.  A phase I trial of intravenous catumaxomab: a bispecific monoclonal antibody targeting EpCAM and the T cell coreceptor CD3 , 2015, Cancer Chemotherapy and Pharmacology.

[8]  L. Álvarez-Vallina,et al.  Microencapsulation of therapeutic bispecific antibodies producing cells: immunotherapeutic organoids for cancer management , 2015, Journal of drug targeting.

[9]  Albrecht Reichle,et al.  Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[10]  S. Akber.  A new approach to cancer treatment* , 2014, Journal of Radiotherapy in Practice.

[11]  G. Ehninger,et al.  Development of a Bispecific Antibody-Releasing Stem Cell System for the Eradication of Acute Myeloid Leukemia Blasts Via Redirected Immune Effector Cells , 2014 .

[12]  J. Friedrichs,et al.  Cryogel Micromechanics Unraveled by Atomic Force Microscopy‐Based Nanoindentation , 2014, Advanced healthcare materials.

[13]  Nicholas A Peppas,et al.  Hydrogels and Scaffolds for Immunomodulation , 2014, Advanced materials.

[14]  E. Eggenhofer,et al.  The Life and Fate of Mesenchymal Stem Cells , 2014, Front. Immunol..

[15]  J. Steinbach,et al.  Effect of [(18)F]FMISO stratified dose-escalation on local control in FaDu hSCC in nude mice. , 2014, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[16]  J. Steinbach,et al.  Radiolabeled anti-EGFR-antibody improves local tumor control after external beam radiotherapy and offers theragnostic potential. , 2014, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[17]  Jianlin Yuan,et al.  Protective Effects of Mesenchymal Stem Cells with CXCR4 Up-Regulation in a Rat Renal Transplantation Model , 2013, PloS one.

[18]  Lieping Chen,et al.  Cancer immunotherapy: are we there yet? , 2013, Experimental Hematology & Oncology.

[19]  G. Ehninger,et al.  Enhancing The Efficacy and Specificity Of Antibody-Based T Cell Retargeting Strategies Against Hematological Malignancies , 2013 .

[20]  Paul J Conroy,et al.  A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications , 2013, Trends in Biotechnology.

[21]  S. Brocchini,et al.  Antibody fragments: Prolonging circulation half-life special issue-antibody research , 2013 .

[22]  G. Ehninger,et al.  Redirection of T cells with a first fully humanized bispecific CD33–CD3 antibody efficiently eliminates AML blasts without harming hematopoietic stem cells , 2013, Leukemia.

[23]  David J Mooney,et al.  Injectable preformed scaffolds with shape-memory properties , 2012, Proceedings of the National Academy of Sciences.

[24]  G. Ehninger,et al.  Novel Humanized and Highly Efficient Bispecific Antibodies Mediate Killing of Prostate Stem Cell Antigen-Expressing Tumor Cells by CD8+ and CD4+ T Cells , 2012, The Journal of Immunology.

[25]  G. Gurtner,et al.  Mesenchymal Stem Cells Home to Sites of Injury and Inflammation. , 2012, Advances in wound care.

[26]  C. Werner,et al.  Macroporous starPEG-heparin cryogels. , 2012, Biomacromolecules.

[27]  S. Banerjee,et al.  Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications , 2012, Journal of drug delivery.

[28]  T. Gajewski,et al.  Cancer immunotherapy , 2012, Molecular oncology.

[29]  Jens Pietzsch,et al.  Design, evaluation, and comparison of ghrelin receptor agonists and inverse agonists as suitable radiotracers for PET imaging. , 2012, Bioconjugate chemistry.

[30]  M. Machluf,et al.  Alginate encapsulated cells secreting Fas‐ligand reduce lymphoma carcinogenicity , 2012, Cancer science.

[31]  George Coukos,et al.  Cancer immunotherapy comes of age , 2011, Nature.

[32]  M. Ravic,et al.  A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin lymphoma. , 2011, Blood.

[33]  A. Temme,et al.  Retargeting of T cells to prostate stem cell antigen expressing tumor cells: Comparison of different antibody formats , 2011, The Prostate.

[34]  C. Figdor,et al.  Mesenchymal stem cells respond to TNF but do not produce TNF , 2010, Journal of leukocyte biology.

[35]  S. Yakar,et al.  Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastases. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

[36]  L. Álvarez-Vallina,et al.  Tumor Immunotherapy Using Gene-Modified Human Mesenchymal Stem Cells Loaded into Synthetic Extracellular Matrix Scaffolds , 2009, Stem cells.

[37]  Michael Baumann,et al.  Comparison of [18F]FDG uptake and distribution with hypoxia and proliferation in FaDu human squamous cell carcinoma (hSCC) xenografts after single dose irradiation , 2009, International journal of radiation biology.

[38]  D. Martineau,et al.  Neo-organoid of marrow mesenchymal stromal cells secreting interleukin-12 for breast cancer therapy. , 2008, Cancer research.

[39]  M. Krieg,et al.  Tensile forces govern germ-layer organization in zebrafish , 2008, Nature Cell Biology.

[40]  Matthias Schieker,et al.  Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer , 2008, Journal of cellular and molecular medicine.

[41]  Sundararajan V Madihally,et al.  Cell colonization in degradable 3D porous matrices , 2008, Cell adhesion & migration.

[42]  I. Davis,et al.  Tumor Antigen Expression in Melanoma Varies According to Antigen and Stage , 2006, Clinical Cancer Research.

[43]  I. Bellantuono,et al.  A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. , 2004, Blood.

[44]  M. Croft.  Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? , 2003, Nature Reviews Immunology.

[45]  K. Lachapelle,et al.  A neovascularized organoid derived from retrovirally engineered bone marrow stroma leads to prolonged in vivo systemic delivery of erythropoietin in nonmyeloablated, immunocompetent mice , 2003, Gene Therapy.

[46]  J. Bechhoefer,et al.  Calibration of atomic‐force microscope tips , 1993 .

[47]  C S Patlak,et al.  Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[48]  G. Ehninger,et al.  Costimulation improves the killing capability of T cells redirected to tumor cells expressing low levels of CD33: description of a novel modular targeting system , 2014, Leukemia.

[49]  Teodor Gotszalk,et al.  Calibration of atomic force microscope , 2008 .

[50]  T. Watts,et al.  TNF/TNFR family members in costimulation of T cell responses. , 2005, Annual review of immunology.