Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers

[1]  Jérémie Rossy,et al.  Ezrin/radixin/moesin: versatile controllers of signaling molecules and of the cortical cytoskeleton. , 2008, The international journal of biochemistry & cell biology.

[2]  J. Partanen,et al.  3D view to tumor suppression: lkb1, polarity and the arrest of oncogenic c-myc , 2009, Cell cycle.

[3]  W. Link,et al.  Membrane localization of all class I PI 3‐kinase isoforms suppresses c‐Myc‐induced apoptosis in Rat1 fibroblasts via Akt , 2005, Journal of cellular biochemistry.

[4]  Marissa E. Nolan,et al.  The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. , 2008, Cancer research.

[5]  B. Hemmings,et al.  PI3K-PKB/Akt pathway. , 2012, Cold Spring Harbor perspectives in biology.

[6]  F. Nwariaku,et al.  p66Shc mediates anoikis through RhoA , 2007, The Journal of cell biology.

[7]  Gary D Bader,et al.  Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling. , 2010, The Biochemical journal.

[8]  Dongmin Gu,et al.  Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity. , 2009, Cold Spring Harbor perspectives in biology.

[9]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[10]  I. Hariharan,et al.  Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. , 2006, Annual review of genetics.

[11]  S. Lowe,et al.  Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy , 2004, Nature.

[12]  G. Evan,et al.  Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB , 1997, Nature.

[13]  Miranda Thomas,et al.  Human tumour viruses and the deregulation of cell polarity in cancer , 2012, Nature Reviews Cancer.

[14]  B. Margolis,et al.  Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells , 2005, Journal of Cell Science.

[15]  George A. R. Wiggins,et al.  E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition , 2014, BMC Cancer.

[16]  Jayanta Debnath,et al.  Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. , 2003, Methods.

[17]  H. Richardson,et al.  scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila , 2003, The EMBO journal.

[18]  Z. Werb,et al.  Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity , 2012, Proceedings of the National Academy of Sciences.

[19]  Fan Mou,et al.  Protein kinases of the Hippo pathway: regulation and substrates. , 2012, Seminars in cell & developmental biology.

[20]  E. Cameron,et al.  The Runx genes: lineage-specific oncogenes and tumor suppressors , 2004, Oncogene.

[21]  Jayanta Debnath,et al.  The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini , 2002, Cell.

[22]  S. Lechuga,et al.  ZO‐2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis , 2012, Annals of the New York Academy of Sciences.

[23]  Tzu-Ling Cheng,et al.  Regulation of anoikis by Cdc42 and Rac1. , 2004, Experimental cell research.

[24]  T. Stein,et al.  PKCζ regulates cell polarisation and proliferation restriction during mammary acinus formation , 2010, Journal of Cell Science.

[25]  H. Richardson,et al.  Using Drosophila melanogaster to map human cancer pathways , 2005, Nature Reviews Cancer.

[26]  T. Mäkelä,et al.  Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization , 2007, Proceedings of the National Academy of Sciences.

[27]  P. Kovanen,et al.  Faulty epithelial polarity genes and cancer. , 2011, Advances in Cancer Research.

[28]  J. Montalbano,et al.  Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis. , 2012, Cancer cell.

[29]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[30]  Benjamin J. Raphael,et al.  Mutational landscape and significance across 12 major cancer types , 2013, Nature.

[31]  C. Scuoppo,et al.  Dysregulation of Cell Polarity Proteins Synergize with Oncogenes or the Microenvironment to Induce Invasive Behavior in Epithelial Cells , 2012, PloS one.

[32]  A. Georgiadis,et al.  Regulation of PCNA and Cyclin D1 Expression and Epithelial Morphogenesis by the ZO-1-Regulated Transcription Factor ZONAB/DbpA , 2006, Molecular and Cellular Biology.

[33]  A. Le Bivic,et al.  Polarity complex proteins. , 2008, Biochimica et biophysica acta.

[34]  Xi He,et al.  Wnt/beta-catenin signaling: components, mechanisms, and diseases. , 2009, Developmental cell.

[35]  D Bilder,et al.  Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. , 2000, Science.

[36]  Tian Xu,et al.  A Genetic Screen in Drosophila for Metastatic Behavior , 2003, Science.

[37]  R. Medema,et al.  Myc‐induced proliferation and transformation require Akt‐mediated phosphorylation of FoxO proteins , 2004, The EMBO journal.

[38]  S. Muthuswamy,et al.  Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators. , 2010, Current opinion in genetics & development.

[39]  P. Cohen,et al.  Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα , 1997, Current Biology.

[40]  T. Brody,et al.  The Interactive Fly: gene networks, development and the Internet. , 1999, Trends in Genetics.

[41]  Valeri Vasioukhin,et al.  Cell polarity and cancer – cell and tissue polarity as a non-canonical tumor suppressor , 2008, Journal of Cell Science.

[42]  P. Meltzer,et al.  PAR6B is required for tight junction formation and activated PKCζ localization in breast cancer. , 2012, American journal of cancer research.

[43]  J. Brugge,et al.  Outgrowth of Single Oncogene-expressing Cells from Suppressive Epithelial Environments , 2012, Nature.

[44]  Ricky W Johnstone,et al.  AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer , 2011, Science Signaling.

[45]  A. McClatchey,et al.  Nf2/Merlin: a coordinator of receptor signalling and intercellular contact , 2007, British Journal of Cancer.

[46]  Sophie Lelièvre,et al.  beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. , 2002, Cancer cell.

[47]  M. Perez-Moreno,et al.  Epithelial cell polarity, stem cells and cancer , 2011, Nature Reviews Cancer.

[48]  Chris Sander,et al.  MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to mTOR Inhibitors , 2011, PloS one.

[49]  Velia M. Fowler,et al.  Tmod3 regulates polarized epithelial cell morphology , 2007, Journal of Cell Science.

[50]  B. Snel,et al.  Evolution and function of the mitotic checkpoint. , 2012, Developmental cell.

[51]  K. Mostov,et al.  From cells to organs: building polarized tissue , 2008, Nature Reviews Molecular Cell Biology.

[52]  A. Hennige,et al.  The Par6α/aPKC complex regulates Akt1 activity by phosphorylating Thr34 in the PH-domain , 2007, Molecular and Cellular Endocrinology.

[53]  Z. Xuan,et al.  Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma , 2008, Cell.

[54]  Xin Lu,et al.  Epithelial cell polarity: a major gatekeeper against cancer? , 2011, Cell Death and Differentiation.