Anti-HMGB 1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma : Attenuated T-Lymphocyte Response and Increased Splenic CD 11 b + Gr-1 + Myeloid-Derived Suppressor Cells Require HMGB 1

1 Department of Anesthesiology, First Municipal People’s Hospital of Guangzhou, Affiliated Hospital of Guangzhou Medical College, Guangzhou, China 2Department of Surgery, University of Pittsburgh, University of Pittsburgh Medical Center, Suite F1281, 200 Lothrop Street, Pittsburgh, PA 15213, USA 3Department of Orthopaedic and Trauma Surgery, Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany

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