GGAs Tie Up the Loose Ends

Cargo receptors, which recruit cargo proteins into transport vesicles, must themselves be sorted into appropriate vesicles budding from the correct cellular compartment. The job of sorting CI-MPR and CD-MPR cargo receptors into newly forming vesicles at the trans-Golgi network (TGN) has been widely attributed to the adaptor protein AP-1. Now, as [Tooze][1] explains in her Perspective, the job of sorting MPRs into TGN vesicles appears to be carried out instead by members of the GGA protein family ([ Zhu et al .][2], [ Puertollano et al .][3]). [1]: http://www.sciencemag.org/cgi/content/full/292/5522/1663 [2]: http://www.sciencemag.org/cgi/content/short/292/5522/1716 [3]: http://www.sciencemag.org/cgi/content/short/292/5522/1712