Norovirus GII-4 causes a more severe gastroenteritis than other noroviruses in young children.

Norovirus (NoV) GII-4 has emerged as the predominant NoV genotype in outbreaks of gastroenteritis worldwide. We determined clinical features of NoV GII-4 associated acute gastroenteritis (AGE) in comparison with AGE associated with other NoV types in infants during seasons 2001 and 2002. During the prospective follow-up period, 128 primary infections of AGE due to NoV were identified in 405 infants; of these, GII-4 was found in 40 cases (31%). NoV GII-4 was associated with longer duration of diarrhea and vomiting than other NoV genotypes, suggesting greater virulence of NoV GII-4.

[1]  P. Teunis,et al.  Differences in clinical presentation between norovirus genotypes in nursing homes. , 2009, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[2]  X. Pang,et al.  Human calicivirus-associated sporadic gastroenteritis in Finnish children less than two years of age followed prospectively during a rotavirus vaccine trial. , 1999, The Pediatric infectious disease journal.

[3]  R. Siezen,et al.  Epochal Evolution of GGII.4 Norovirus Capsid Proteins from 1995 to 2006 , 2007, Journal of Virology.

[4]  M. Estes,et al.  Detection of Norwalk virus or Norwalk-like virus infections in Finnish infants and young children. , 1994, The Journal of infectious diseases.

[5]  L. Maunula,et al.  Norovirus genotypes causing gastroenteritis outbreaks in Finland 1998-2002. , 2005, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[6]  T. Vesikari,et al.  Efficacy of RIX4414 Live Attenuated Human Rotavirus Vaccine in Finnish Infants , 2004, The Pediatric infectious disease journal.

[7]  Harry Vennema,et al.  Increase in viral gastroenteritis outbreaks in Europe and epidemic spread of new norovirus variant , 2004, The Lancet.

[8]  Y. Jing,et al.  Genetic diversity among sapoviruses , 2004, Archives of Virology.

[9]  M. Salimans,et al.  Rapid and simple method for purification of nucleic acids , 1990, Journal of clinical microbiology.

[10]  L. Svensson,et al.  Molecular Epidemiology of Norovirus Infections in Stockholm, Sweden, during the Years 2000 to 2003: Association of the GGIIb Genetic Cluster with Infection in Children , 2005, Journal of Clinical Microbiology.

[11]  T. Vesikari,et al.  Norovirus gastroenteritis in young children receiving human rotavirus vaccine , 2010, Scandinavian journal of infectious diseases.

[12]  T. Vesikari,et al.  Rotavirus disease in Finnish children: use of numerical scores for clinical severity of diarrhoeal episodes. , 1990, Scandinavian journal of infectious diseases.

[13]  X. Jiang,et al.  Design and evaluation of a primer pair that detects both Norwalk- and Sapporo-like caliciviruses by RT-PCR. , 1999, Journal of virological methods.

[14]  A. Bosch,et al.  Molecular Epidemiology of Caliciviruses Causing Outbreaks and Sporadic Cases of Acute Gastroenteritis in Spain , 2002, Journal of Clinical Microbiology.