SGLT2 inhibition eliminates senescent cells and alleviates pathological aging

[1]  David K. Finlay,et al.  Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity. , 2023, Cell metabolism.

[2]  M. Serrano,et al.  Hallmarks of aging: An expanding universe , 2022, Cell.

[3]  A. Sharpe,et al.  Age-associated remodeling of T cell immunity and metabolism. , 2022, Cell metabolism.

[4]  T. Eleftheriadis,et al.  Dapagliflozin Prevents High-Glucose-Induced Cellular Senescence in Renal Tubular Epithelial Cells , 2022, International journal of molecular sciences.

[5]  Y. Furukawa,et al.  Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes , 2022, Nature.

[6]  J. Kirkland,et al.  Cellular senescence and senolytics: the path to the clinic , 2022, Nature Medicine.

[7]  Shujiro Okuda,et al.  Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice , 2021, Nature Aging.

[8]  Hu Li,et al.  p21 produces a bioactive secretome that places stressed cells under immunosurveillance , 2021, Science.

[9]  Y. Cho,et al.  Sodium‐glucose cotransporter‐2 inhibition reduces cellular senescence in the diabetic kidney by promoting ketone body‐induced NRF2 activation , 2021, Diabetes, obesity & metabolism.

[10]  N. LaRusso,et al.  An aged immune system drives senescence and ageing of solid organs , 2021, Nature.

[11]  G. Freeman,et al.  Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade. , 2021, Molecular cell.

[12]  D. Vignali,et al.  Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups , 2019, Nature Immunology.

[13]  M. Jensen,et al.  Targeting senescent cells alleviates obesity‐induced metabolic dysfunction , 2019, Aging cell.

[14]  T. Minamino,et al.  p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia. , 2019, Journal of molecular and cellular cardiology.

[15]  W. Symmans,et al.  Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. , 2018, Molecular cell.

[16]  K. Sugimoto,et al.  Elimination of p19ARF‐expressing cells protects against pulmonary emphysema in mice , 2018, Aging cell.

[17]  K. Sakimura,et al.  Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum , 2018, Nature Communications.

[18]  D. Allison,et al.  Senolytics Improve Physical Function and Increase Lifespan in Old Age , 2018, Nature Medicine.

[19]  E. Ferrannini.  Sodium-Glucose Co-transporters and Their Inhibition: Clinical Physiology. , 2017, Cell metabolism.

[20]  E. Ma,et al.  The role of AMPK in T cell metabolism and function. , 2017, Current opinion in immunology.

[21]  C. Conover,et al.  Senescent intimal foam cells are deleterious at all stages of atherosclerosis , 2016, Science.

[22]  K. Sugimoto,et al.  Elimination of p19ARF-expressing cells enhances pulmonary function in mice. , 2016, JCI insight.

[23]  A. Pezeshki,et al.  Naturally occurring p16Ink4a-positive cells shorten healthy lifespan , 2016, Nature.

[24]  Manuel Serrano,et al.  Cellular senescence: from physiology to pathology , 2014, Nature Reviews Molecular Cell Biology.

[25]  T. Okazaki,et al.  A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application , 2013, Nature Immunology.

[26]  I. Komuro,et al.  p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. , 2012, Cell metabolism.

[27]  Masayuki Orimo,et al.  A crucial role for adipose tissue p53 in the regulation of insulin resistance , 2009, Nature Medicine.

[28]  Issei Komuro,et al.  Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes , 2008, Nature Clinical Practice Cardiovascular Medicine.

[29]  R. Hennekam.  Hutchinson–Gilford progeria syndrome: Review of the phenotype , 2006, American journal of medical genetics. Part A.

[30]  I. Komuro,et al.  Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway , 2004, The EMBO journal.