MRI assessment of cerebral blood volume in patients with brain infarcts

Abstract MRI perfusion studies have focussed mainly on acute ischaemia and characterisation in ischaemia. Our purpose was to analyse regional brain haemodynamic information in acute, subacute, and chronic ischaemia. We performed 16 examinations of 11 patients on a 1.5 T MR images. Conventional and dynamic contrast-enhanced imaging were employed in all examinations. For the dynamic susceptibility sequences, a bolus (0.2 mmol/kg) of gadopentetate dimeglumine was injected. Reconstructed regional relative cerebral blood volume (rCBV) maps, bolus maps, and conventional images were analysed by consensus reading. In all examinations decreases in rCBV were observed in the lesions. The distribution of regional rCBV in lesions was heterogeneous. The rCBV of the periphery of the lesions was higher than that at their center. There was a correlation between the time since onset and abnormalities on the rCBV map and T2-weighted images (T2WI). In the early stage of acute stroke, the abnormalities tended to be larger on the rCBV than on T2WI. Many patterns of bolus passage were observed in ischaemic regions. rCBV maps provide additional haemodynamic information in patients with brain infarcts.

[1]  M. Hennerici,et al.  Assessment of regional cerebral blood volume in acute human stroke by use of single-slice dynamic susceptibility contrast-enhanced magnetic resonance imaging. , 1996, Stroke.

[2]  U. Mödder,et al.  Einsatzmöglichkeiten von kernspintomographischen Parameterbildern des zerebralen Blutvolumens in der Diagnostik von Hirntumoren , 1995 .

[3]  J W Belliveau,et al.  Functional cerebral imaging by susceptibility‐contrast NMR , 1990, Magnetic resonance in medicine.

[4]  J. Kurhanewicz,et al.  Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats. , 1990, AJNR. American journal of neuroradiology.

[5]  F. Binkofski,et al.  Kernspintomographische Blutvolumenmessungen in der Diagnostik des Schlaganfalls: Ergebnisse einer klinischen Pilotstudie , 1996 .

[6]  D. Marquardt An Algorithm for Least-Squares Estimation of Nonlinear Parameters , 1963 .

[7]  M. Reiser,et al.  Regional relative blood volume MR maps of meningiomas before and after partial embolization. , 1998, Journal of computer assisted tomography.

[8]  M. Reiser,et al.  Diffusion measurements in the ischemic human brain with a steady-state sequence. , 1996, Investigative radiology.

[9]  T. Kent,et al.  Cerebral blood volume in a rat model of ischemia by MR imaging at 4.7 T. , 1989, AJNR. American journal of neuroradiology.

[10]  F. Godtliebsen,et al.  Combined perfusion and diffusion-weighted magnetic resonance imaging in a rat model of reversible middle cerebral artery occlusion. , 1995, Stroke.

[11]  T. L. Davis,et al.  Hyperacute stroke: evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo-planar MR imaging. , 1996, Radiology.

[12]  B R Rosen,et al.  Echo-planar MR determination of relative cerebral blood volume in human brain tumors: T1 versus T2 weighting. , 1996, AJNR. American journal of neuroradiology.

[13]  S. Heiland,et al.  Early MR detection of experimentally induced cerebral ischemia using magnetic susceptibility contrast agents: comparison between gadopentetate dimeglumine and iron oxide particles. , 1995, AJNR. American journal of neuroradiology.

[14]  J W Belliveau,et al.  Measurement of Cerebrovascular Changes in Cats After Transient Ischemia Using Dynamic Magnetic Resonance Imaging , 1993, Stroke.

[15]  Mark S. Cohen,et al.  Contrast agents and cerebral hemodynamics , 1991, Magnetic resonance in medicine.

[16]  M E Moseley,et al.  Echo-planar perfusion-sensitive MR imaging of acute cerebral ischemia. , 1993, Radiology.

[17]  M E Moseley,et al.  Early detection of ischemic injury: comparison of spectroscopy, diffusion-, T2-, and magnetic susceptibility-weighted MRI in cats. , 1990, Acta neurochirurgica. Supplementum.

[18]  S. Majumdar,et al.  Cerebral perfusion in children: detection with dynamic contrast-enhanced T2*-weighted MR images. , 1993, Radiology.

[19]  B. Rosen,et al.  MR Contrast Due to Microscopically Heterogeneous Magnetic Susceptibility: Numerical Simulations and Applications to Cerebral Physiology , 1991, Magnetic resonance in medicine.

[20]  Wei Li,et al.  Acute cerebral ischemia: evaluation with dynamic contrast-enhanced MR imaging and MR angiography. , 1992, Radiology.

[21]  T. Matsuda,et al.  Acute stroke in cats: comparison of dynamic susceptibility-contrast MR imaging with T2- and diffusion-weighted MR imaging. , 1993, Radiology.

[22]  M. Knopp,et al.  Age dependency of the regional cerebral blood volume (rCBV) measured with dynamic susceptibility contrast MR imaging (DSC). , 1996, Magnetic resonance imaging.

[23]  W. J. Lorenz,et al.  Quantification of regional cerebral blood flow and volume with dynamic susceptibility contrast-enhanced MR imaging. , 1994, Radiology.

[24]  B. Rosen,et al.  Dynamic imaging with lanthanide chelates in normal brain: Contrast due to magnetic susceptibility effects , 1988, Magnetic resonance in medicine.

[25]  G Brix,et al.  Assessment of Cerebral Blood Volume with Dynamic Susceptibility Contrast Enhanced Gradient‐Echo Imaging , 1994, Journal of computer assisted tomography.

[26]  T Hackländer,et al.  Cerebral blood volume maps with dynamic contrast-enhanced T1-weighted FLASH imaging: normal values and preliminary clinical results. , 1996, Journal of computer assisted tomography.