Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors.
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A. Linusson | G. Mangiatordi | T. Latronico | G. M. Liuzzi | M. Catto | L. Pisani | Sara Marchese | Pietro Delre | D. V. Miniero | C. Binda | Mariagrazia Rullo | Margherita Mastromarino | Andrea Gottinger | Gabriella La Spada
[1] A. Linusson,et al. Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies. , 2022, Journal of medicinal chemistry.
[2] F. Ekström,et al. Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures , 2022, ACS medicinal chemistry letters.
[3] Giuseppe Felice Mangiatordi,et al. Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study , 2021, J. Chem. Inf. Model..
[4] Gregory A Ross,et al. OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space. , 2021, Journal of chemical theory and computation.
[5] G. Zengin,et al. Role of Monoamine Oxidase Activity in Alzheimer’s Disease: An Insight into the Therapeutic Potential of Inhibitors , 2021, Molecules.
[6] Shoaib Manzoor,et al. A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer's disease agents: A review. , 2020, European journal of medicinal chemistry.
[7] M. Saviano,et al. Repurposing Known Drugs as Covalent and Non-covalent Inhibitors of the SARS-CoV-2 Papain-Like Protease , 2020, Frontiers in Chemistry.
[8] A. Mattevi,et al. Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging , 2020, ACS chemical biology.
[9] B. Salehi,et al. Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health , 2020, ACS omega.
[10] C. Datta,et al. Role of Monoamine Oxidase A (MAO-A) in Cardiac Aging , 2020 .
[11] Janez Konc,et al. Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B , 2020, Journal of medicinal chemistry.
[12] S. Carradori,et al. Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement? , 2019, Expert opinion on drug discovery.
[13] Ashwini M. Londhe,et al. Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease , 2019, Science Advances.
[14] Allen F. Brooks,et al. Classics in Neuroimaging: Development of PET Tracers for Imaging Monoamine Oxidases. , 2019, ACS chemical neuroscience.
[15] E. Uriarte,et al. Quercetin and Related Chromenone Derivatives as Monoamine Oxidase Inhibitors: Targeting Neurological and Mental Disorders , 2019, Molecules.
[16] R. Iacobazzi,et al. Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors. , 2019, European journal of medicinal chemistry.
[17] J. Shih. Monoamine oxidase isoenzymes: genes, functions and targets for behavior and cancer therapy , 2018, Journal of Neural Transmission.
[18] Chun-Peng Liao,et al. Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate , 2018, Oncogene.
[19] S. Carradori,et al. MAO inhibitors and their wider applications: a patent review , 2018, Expert opinion on therapeutic patents.
[20] O. Nicolotti,et al. Mannich base approach to 5‐methoxyisatin 3‐(4‐isopropylphenyl)hydrazone: A water‐soluble prodrug for a multitarget inhibition of cholinesterases, beta‐amyloid fibrillization and oligomer‐induced cytotoxicity , 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[21] Lirong Wang,et al. ProSelection: A Novel Algorithm to Select Proper Protein Structure Subsets for in Silico Target Identification and Drug Discovery Research , 2017, J. Chem. Inf. Model..
[22] M. Catto,et al. Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo‐ and Heterodimerization of Coumarin‐Based Moieties , 2017, ChemMedChem.
[23] B. Winblad,et al. Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels , 2017, Alzheimer's Research & Therapy.
[24] G. Lattanzi,et al. A rational approach to elucidate human monoamine oxidase molecular selectivity , 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[25] Lydia Siragusa,et al. Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents. , 2016, Journal of medicinal chemistry.
[26] Sheetal,et al. Recent developments on the structure–activity relationship studies of MAO inhibitors and their role in different neurological disorders , 2016 .
[27] S. Genheden,et al. The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities , 2015, Expert opinion on drug discovery.
[28] Meryem Köse,et al. 8‐Benzyltetrahydropyrazino[2,1‐f]purinediones: Water‐Soluble Tricyclic Xanthine Derivatives as Multitarget Drugs for Neurodegenerative Diseases , 2014, ChemMedChem.
[29] C. Müller,et al. Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency. , 2014, Journal of medicinal chemistry.
[30] H. Sies. Role of Metabolic H2O2 Generation , 2014, The Journal of Biological Chemistry.
[31] O. Nicolotti,et al. Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors. , 2013, European journal of medicinal chemistry.
[32] R. Ramsay. Inhibitor design for monoamine oxidases. , 2013, Current pharmaceutical design.
[33] Walter Cabri,et al. Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors. , 2013, Journal of medicinal chemistry.
[34] C. Saal,et al. Optimizing solubility: kinetic versus thermodynamic solubility temptations and risks. , 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[35] Andrea Mattevi,et al. Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs. , 2012, ACS medicinal chemistry letters.
[36] A. Mattevi,et al. The ‘gating’ residues Ile199 and Tyr326 in human monoamine oxidase B function in substrate and inhibitor recognition , 2011, The FEBS journal.
[37] K. Fujimori,et al. Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells , 2011, Neuroscience Letters.
[38] J. P. Petzer,et al. Inhibition of monoamine oxidase by indole and benzofuran derivatives. , 2010, European journal of medicinal chemistry.
[39] C. Caccia,et al. Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B i , 2009, Journal of medicinal chemistry.
[40] F. Forneris,et al. ThermoFAD, a Thermofluor®‐adapted flavin ad hoc detection system for protein folding and ligand binding , 2009, The FEBS journal.
[41] E. Yamashita,et al. Structure of human monoamine oxidase A at 2.2-Å resolution: The control of opening the entry for substrates/inhibitors , 2008, Proceedings of the National Academy of Sciences.
[42] R. Lea,et al. Monoamine oxidase and tobacco dependence. , 2007, Neurotoxicology.
[43] Keith F. Tipton,et al. The therapeutic potential of monoamine oxidase inhibitors , 2006, Nature Reviews Neuroscience.
[44] Andrea Mattevi,et al. Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[45] Andrea Mattevi,et al. Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[46] Enzo Agostinelli,et al. Simple, potent, and selective pyrrole inhibitors of monoamine oxidase types A and B. , 2003, Journal of medicinal chemistry.
[47] K. Castagnoli,et al. Synthesis and biological evaluation of MAO-A selective 1,4-disubstituted-1,2,3,6-tetrahydropyridinyl substrates. , 2002, Bioorganic & medicinal chemistry.
[48] R. Copeland. Tight Binding Inhibitors , 2002 .
[49] R. Friesner,et al. Evaluation and Reparametrization of the OPLS-AA Force Field for Proteins via Comparison with Accurate Quantum Chemical Calculations on Peptides† , 2001 .
[50] D. Edmondson,et al. High-level expression of human liver monoamine oxidase B in Pichia pastoris. , 2000, Protein expression and purification.
[51] J. Shih,et al. Monoamine oxidase: from genes to behavior. , 1999, Annual review of neuroscience.
[52] V. Chan‐Palay,et al. Increased monoamine oxidase b activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography , 1994, Neuroscience.
[53] M. Berridge,et al. Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. , 1993, Archives of biochemistry and biophysics.
[54] K. Tipton,et al. Interactions of monoamine oxidase with substrates and inhibitors , 1989, Medicinal research reviews.
[55] W. Haefely,et al. On tyramine, food, beverages and the reversible MAO inhibitor moclobemide. , 1988, Journal of neural transmission. Supplementum.
[56] E. Zeller,et al. In vivo Inhibition of Liver and Brain Monoamine Oxidase by 1-Isonicotinyl-2-Isopropyl Hydrazine.∗ , 1952, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.