论文信息 - HL-A haplotype frequencies in Denmark and Norway.

HL-A haplotype frequencies in Denmark and Norway.

A total of 1,291 Danish and Norwegian random HL—A haplotypes in 338 families were studied. Ninety-nine different haplotypes could be distinguished and their frequencies were estimated (1) from the entire family data and (2) from the parental phenotype (population) data alone. The results obtained with these two methods compared fairly well. No significant differences could be demonstrated for the frequencies of the different haplotypes in Denmark and Norway. Estimates were calculated for the gametic associations (D values) of the various sets of genetic determinants from the first and second segregant series of the HL-A system. The gametic associations seemed to be strongest in Norway. The segregation ratios of the HL-A1, 8 and 3, 7 haplotypes were analysed and showed no deviation from expectations.

E. Thorsby | A. Svejgaard | M. Hauge | F. Kissmeyer-Nielsen

[1] E. Thorsby,et al. The HL-A system: antigenic heterogeneity and four new antigens. , 2008 .

[2] E. Thorsby,et al. HL-A antigens and susceptibility to diseases. A study of patients with acute lymphoblastic leukaemia, Hodgkin's disease, and childhood asthma. , 2008, Tissue antigens.

[3] E. Thorsby,et al. The recombination fraction of the HL-A system. , 2008, Tissue antigens.

[4] E. Thorsby,et al. The HL‐A Transplantation System , 1971 .

[5] E. Thorsby,et al. HL-A haplotypes and their inheritance. , 1971, Transplantation proceedings.

[6] E. Thorsby,et al. Possibility of a third sublocus. , 1971, Transplantation proceedings.

[7] J G Bodmer,et al. Studies on African Pygmies. IV. A comparative study of the HL-A polymorphism in the Babinga Pygmies and other African and Caucasian populations. , 1970, American journal of human genetics.

[8] E. Thorsby,et al. Genetics of the HL‐A System A Population and Family Study , 1970, Vox sanguinis.

[9] M. Kimura,et al. A ǵene‐countinǵ method of maximum likelihood for estimating ǵenefrequencies in ABO and ABO‐like systems * , 1968, Annals of human genetics.