Ethanol Intoxication in Drosophila: Genetic and Pharmacological Evidence for Regulation by the cAMP Signaling Pathway

[1]  T. Yagi,et al.  Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. , 1997, Science.

[2]  M. Cann,et al.  Cloning and characterization of a Drosophila adenylyl cyclase homologous to mammalian type IX , 1997, FEBS Letters.

[3]  I. Diamond,et al.  Cellular and molecular neuroscience of alcoholism. , 1997, Physiological reviews.

[4]  R. Hen,et al.  Elevated alcohol consumption in null mutant mice lacking 5–HT1B serotonin receptors , 1996, Nature Genetics.

[5]  K. Buck Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol , 1996, Behavior genetics.

[6]  B. Tabakoff,et al.  Alcohol Addiction: An Enigma among Us , 1996, Neuron.

[7]  F. Crews,et al.  Effects of ethanol on ion channels. , 1996, International review of neurobiology.

[8]  W. Quinn,et al.  A neuropeptide gene defined by the Drosophila memory mutant amnesiac. , 1995, Science.

[9]  S. Tonegawa,et al.  Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type A receptors. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[10]  JF Ferveur,et al.  Genetic feminization of brain structures and changed sexual orientation in male Drosophila , 1995, Science.

[11]  D. Lovinger,et al.  Cellular and behavioral neurobiology of alcohol: receptor-mediated neuronal processes. , 1995, Clinical neuroscience.

[12]  J. Crabbe,et al.  Genetic animal models of alcohol and drug abuse. , 1994, Science.

[13]  M Heisenberg,et al.  Associative odor learning in Drosophila abolished by chemical ablation of mushroom bodies. , 1994, Science.

[14]  M. Schuckit Low level of response to alcohol as a predictor of future alcoholism. , 1994, The American journal of psychiatry.

[15]  Ronald L. Davis,et al.  Preferential expression in mushroom bodies of the catalytic subunit of protein kinase A and its role in learning and memory , 1993, Neuron.

[16]  D. Kalderon,et al.  Genetic investigation of cAMP-dependent protein kinase function in Drosophila development. , 1993, Genes & development.

[17]  Ronald L. Davis,et al.  Preferential expression of the drosophila rutabaga gene in mushroom bodies, neural centers for learning in insects , 1992, Neuron.

[18]  Ronald L. Davis,et al.  The Drosophila learning and memory gene rutabaga encodes a Ca 2+ calmodulin -responsive , 1992, Cell.

[19]  Y. Hiromi,et al.  Enhancer Trap Method in Drosophila: Its Application to Neurobiology , 1992 .

[20]  R. Davis,et al.  Characterization of the memory gene dunce of Drosophila melanogaster. , 1991, Journal of molecular biology.

[21]  Ronald L. Davis,et al.  The cyclic AMP phosphodiesterase encoded by the drosophila dunce gene is concentrated in the mushroom body neuropil , 1991, Neuron.

[22]  T. Dunwiddie,et al.  Genetic differences in the ethanol sensitivity of GABAA receptors expressed in Xenopus oocytes. , 1990, Science.

[23]  C. Wilson,et al.  P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. , 1989, Genes & development.

[24]  J. Rothermel,et al.  A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. , 1988, The Biochemical journal.

[25]  M. Schuckit,et al.  A simultaneous evaluation of multiple markers of ethanol/placebo challenges in sons of alcoholics and controls. , 1988, Archives of general psychiatry.

[26]  B. Tabakoff,et al.  Differences in platelet enzyme activity between alcoholics and nonalcoholics. , 1988, The New England journal of medicine.

[27]  I. Diamond,et al.  Basal and adenosine receptor-stimulated levels of cAMP are reduced in lymphocytes from alcoholic patients. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[28]  R. Davis,et al.  Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[29]  A. Hoffmann,et al.  Genetic divergence under uniform selection. II. Different responses to selection for knockdown resistance to ethanol among Drosophila melanogaster populations and their replicate lines. , 1986, Genetics.

[30]  T. Tully,et al.  Deletion mapping of the Drosophila memory mutant amnesiac. , 1986, Journal of neurogenetics.

[31]  M. Livingstone,et al.  Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant , 1984, Cell.

[32]  R. Doolittle,et al.  A simple method for displaying the hydropathic character of a protein. , 1982, Journal of molecular biology.

[33]  Ronald L. Davis,et al.  Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system , 1981, The Journal of cell biology.

[34]  Ronald L. Davis,et al.  Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster , 1981, Nature.

[35]  W. Quinn,et al.  The Drosophila memory mutant amnesiac , 1979, Nature.

[36]  J. Mohler Developmental genetics of the Drosophila egg. I. Identification of 59 sex-linked cistrons with maternal effects on embryonic development. , 1977, Genetics.

[37]  Y. Jan,et al.  dunce, a mutant of Drosophila deficient in learning. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[38]  J. Raymond [Cyclic AMP]. , 1972, La Nouvelle presse medicale.