Aromatic Amines and Biomarkers of Human Exposure

Biomarkers are determinants in blood, urine, or exhaled air that estimate exposure, susceptibility, or approximate effect. Biomarkers are finding increasing use in the context of occupational and environmental exposures. For example, the Biological Exposure Indices (BEI) Committee of the American Conference of Governmental Industrial Hygienists (ACGIH) has recommended the use of biomarkers to estimate occupational exposure to more than 40 chemical agents (1) and the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area similarly has established guides for the use of biomarkers for about 80 compounds (2). The impetus for the use of biomarkers comes from a public health model for cancer prevention that emphasizes primary and secondary interventions to prevent disease over the treatment of disease model (3). Exposure to certain aromatic amines is clearly related to human bladder cancer

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