论文信息 - Proton beams generated with high-intensity lasers: Applications to medical isotope production

Proton beams generated with high-intensity lasers: Applications to medical isotope production

Proton beams of up to 10 MeV have been obtained by the interaction of a 10 Hz “table-top” laser, focused to intensities of 6×10^19 W/cm^2, with 6-μm-thin foil targets. Such proton beams can be used to induce 11B(p,n)11C reactions, which could yield an integrated activity of 13.4 MBq (0.36 mCi) after 30 min laser irradiation. This can be extended to GBq levels using similar lasers with kilohertz repetition rates, making this positron-emission tomography isotope production scheme comparable to the one using conventional accelerators.

[1] Edward B. Clark,et al. Experimental study of proton emission from 60-fs, 200-mJ high-repetition-rate tabletop-laser pulses interacting with solid targets. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[2] A. E. Dangor,et al. Laser generation of proton beams for the production of short-lived positron emitting radioisotopes , 2001 .

[3] M. Pittman,et al. Design and characterization of a near-diffraction-limited femtosecond 100-TW 10-Hz high-intensity laser system , 2002 .

[4] Thomas Alan Mehlhorn,et al. A finite material temperature model for ion energy deposition in ion‐driven inertial confinement fusion targets , 1981 .

[5] Gerard Mourou,et al. Laser-triggered ion acceleration and table top isotope production , 2001 .

[6] A. E. Dangor,et al. Production of radioactive nuclides by energetic protons generated from intense laser-plasma interactions , 2001 .

[7] T. C. Sangster,et al. Intense high-energy proton beams from Petawatt-laser irradiation of solids. , 2000, Physical review letters.

[8] Manuel Aguilar-Benitez,et al. Review of Particle Physics, 1996-1997 , 1996 .