Biomedical applications of terahertz technology

Abstract In order to meet the requirements of sustainable growth and development for human beings, biomedical research has been the focus of our attention. Terahertz (THz) is recognized as one of the most promising technologies and it has been widely used in biomedicine. A depiction of the basic principle of THz spectroscopy and THz imaging at the beginning of this article, some emerging techniques like THz microfluidic chips and scattering-type scanning near-field THz spectroscopy (S-SNTS) are investigated as well and it is indicated that these techniques have the potential to tackle some shortcomings of THz technology. This article reviews the applications of THz characterization techniques and THz biological effects in biomedicine between 2010 and 2018. The applications of THz characterization techniques are overviewed by five parts: amino acid and polypeptide, DNA, protein, the detection of cancer, and other applications. The research of THz biological effects mainly concentrates on the effect of THz on the tissue and cells of organisms. Besides, this article briefly introduces the basics of chemometric methods which are mainly applied in data preprocessing and multivariate analysis. Furthermore, we address the drawbacks of THz technology in biomedicine at the end of this article, these need our further study.

[1]  Daniel M Mittleman,et al.  Twenty years of terahertz imaging [Invited]. , 2018, Optics express.

[2]  Jun-ichi Nishizawa,et al.  Terahertz-wave spectroscopy for precise histopathological imaging of tumor and non-tumor lesions in paraffin sections. , 2011, The Tohoku journal of experimental medicine.

[3]  P. Glancy,et al.  Concentration-dependent effects on fully hydrated DNA at terahertz frequencies , 2015, Journal of biological physics.

[4]  N. Kolchanov,et al.  No DNA damage response and negligible genome-wide transcriptional changes in human embryonic stem cells exposed to terahertz radiation , 2015, Scientific Reports.

[5]  Ke Yang,et al.  Biomedical Applications of Terahertz Spectroscopy and Imaging. , 2016, Trends in biotechnology.

[6]  Warren S. Grundfest,et al.  Reflective THz and MR imaging of burn wounds: a potential clinical validation of THz contrast mechanisms , 2012, Optical Engineering + Applications.

[7]  Jingxian Wu,et al.  Pulsed terahertz imaging of breast cancer in freshly excised murine tumors , 2018, Journal of biomedical optics.

[8]  S. G. Brouwer de Koning,et al.  Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue. , 2017, Biomedical optics express.

[9]  Warren S. Grundfest,et al.  Advances in biomedical imaging using THz technology with applications to burn-wound assessment , 2012, OPTO.

[10]  W. Fan,et al.  First principles investigation of L-alanine in terahertz region , 2012, Journal of biological physics.

[11]  Keisuke Tominaga,et al.  Low-Frequency Spectra of Amino Acids and Short-Chain Peptides Studied by Terahertz Time-Domain Spectroscopy , 2010 .

[12]  Martin O Culjat,et al.  Terahertz sensing in corneal tissues. , 2011, Journal of biomedical optics.

[13]  Huo Zhang,et al.  Discrimination of traditional herbal medicines based on terahertz spectroscopy , 2017 .

[14]  M. Tani,et al.  A direct comparison between terahertz time-domain spectroscopy and far-infrared Fourier transform spectroscopy , 2001 .

[15]  Hans Christian Bakken Skjeie.  Terahertz Time-Domain Spectroscopy , 2012 .

[16]  Liangping Xia,et al.  Detection of DNA oligonucleotides with base mutations by terahertz spectroscopy and microstructures , 2018, PloS one.

[17]  Oleksandr Sushko,et al.  Sub-terahertz spectroscopy reveals that proteins influence the properties of water at greater distances than previously detected. , 2015, The Journal of chemical physics.

[18]  Magda El-Shenawee,et al.  Terahertz Imaging of Three-Dimensional Dehydrated Breast Cancer Tumors , 2017 .

[19]  Hakan Altan,et al.  Terahertz pulsed imaging study of dental caries , 2015, European Conference on Biomedical Optics.

[20]  D. Abbott,et al.  Tracking Aggregation and Fibrillation of Globular Proteins Using Terahertz and Far-Infrared Spectroscopies , 2016, IEEE Transactions on Terahertz Science and Technology.

[21]  Olga P. Cherkasova,et al.  The influence of terahertz radiation on the cell’s genetic apparatus , 2017 .

[22]  Dustin G. Mixon,et al.  In vitro investigation of the biological effects associated with human dermal fibroblasts exposed to 2.52 THz radiation , 2011, Lasers in surgery and medicine.

[23]  A. Davies,et al.  Applying broadband terahertz time‐domain spectroscopy to the analysis of crystalline proteins: a dehydration study , 2011 .

[24]  Yong He,et al.  Soil Nitrogen Content Influence on Canopy Reflectance Spectra , 2011 .

[25]  Mattias Beck,et al.  Imaging with a Terahertz quantum cascade laser. , 2004, Optics express.

[26]  杨. Y. Kun,et al.  Comparison Between Pulsed Terahertz Imaging and Continuous-Wave Terahertz Imaging , 2009 .

[27]  Yong He,et al.  Application of Infrared Spectroscopy Technique and Chemometrics for Measurement of Components in Rice after Radiation , 2009 .

[28]  J. Aizpurua,et al.  Terahertz near-field nanoscopy of mobile carriers in single semiconductor nanodevices. , 2008, Nano letters.

[29]  Babar Rao,et al.  Early detection of skin cancer via terahertz spectral profiling and 3D imaging. , 2016, Biosensors & bioelectronics.

[30]  Joo-Hiuk Son,et al.  Toward Clinical Cancer Imaging Using Terahertz Spectroscopy , 2017, IEEE Journal of Selected Topics in Quantum Electronics.

[32]  Bo Zhang,et al.  Terahertz spectroscopic investigation of gallic acid and its monohydrate. , 2018, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[33]  K. Erande,et al.  Terahertz technology and its applications , 2013 .

[34]  Hui Yan,et al.  [Terahertz spectroscopy of DNA nucleobases: cytosine and thymine]. , 2013, Guang pu xue yu guang pu fen xi = Guang pu.

[35]  Tao Chen,et al.  Application of terahertz science and technology in biology and medicine research: Application of terahertz science and technology in biology and medicine research , 2013 .

[36]  Yi-Bin Ying,et al.  [Research progress of Terahertz wave technology in quality measurement of food and agricultural products]. , 2007, Guang pu xue yu guang pu fen xi = Guang pu.

[37]  Hironaru Murakami,et al.  Invited Article: Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms , 2018 .

[38]  Joo-Hiuk Son,et al.  Terahertz imaging of excised oral cancer at frozen temperature. , 2013, Biomedical optics express.

[39]  J. Orenstein,et al.  Terahertz time-domain spectroscopy , 1998 .

[40]  C. Otani,et al.  Terahertz imaging diagnostics of the cancer tissues with chemometrics technique , 2007, 2006 Joint 31st International Conference on Infrared Millimeter Waves and 14th International Conference on Teraherz Electronics.

[41]  G. Park,et al.  Biological Effects of Femtosecond-Terahertz Pulses on C57BL/6 Mouse Skin , 2014, Annals of dermatology.

[42]  Patrick Kung,et al.  Observation of Hydrofluoric Acid Burns on Osseous Tissues by Means of Terahertz Spectroscopic Imaging , 2013, IEEE Transactions on Terahertz Science and Technology.

[43]  Seung Jae Oh,et al.  Measuring water contents in animal organ tissues using terahertz spectroscopic imaging. , 2018, Biomedical optics express.

[44]  Ke Yang,et al.  Label‐free bacterial colony detection and viability assessment by continuous‐wave terahertz transmission imaging , 2018, Journal of biophotonics.

[45]  June-Soo Park,et al.  High exposure of California firefighters to polybrominated diphenyl ethers. , 2015, Environmental science & technology.

[46]  Yong He,et al.  Quantification of Nitrogen Status in Rice by Least Squares Support Vector Machines and Reflectance Spectroscopy , 2009, Food and Bioprocess Technology.

[47]  A. N. Panin,et al.  Terahertz spectroscopy of DNA , 2013 .

[48]  Nicholette D. Palmer,et al.  Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries , 2018, PloS one.

[49]  Joo-Hiuk Son,et al.  Terahertz molecular resonance of cancer DNA , 2016, Scientific Reports.

[50]  Da-Wen Sun,et al.  Emerging non-destructive terahertz spectroscopic imaging technique: Principle and applications in the agri-food industry , 2017 .

[51]  Emilio Giovenale,et al.  Study of the effects of 0.15 terahertz radiation on genome integrity of adult fibroblasts , 2018, Environmental and molecular mutagenesis.

[52]  Zhuoyong Zhang,et al.  Simultaneous determination of amino acid mixtures in cereal by using terahertz time domain spectroscopy and chemometrics , 2017 .