c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells

[1]  K. Pinkerton,et al.  MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of rats. , 2005, Carcinogenesis.

[2]  Qiang Shen,et al.  cFos is critical for MCF-7 breast cancer cell growth , 2005, Oncogene.

[3]  Andrew D. Yates,et al.  Somatic mutations of the protein kinase gene family in human lung cancer. , 2005, Cancer research.

[4]  J. Ptak,et al.  Colorectal cancer: Mutations in a signalling pathway , 2005, Nature.

[5]  P. LoRusso,et al.  Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  B. Shin,et al.  Urokinase plasminogen activator receptor is upregulated by Helicobacter pylori in human gastric cancer AGS cells via ERK, JNK, and AP-1. , 2005, Biochemical and biophysical research communications.

[7]  G. Kundu,et al.  JNK1 Differentially Regulates Osteopontin-induced Nuclear Factorinducing Kinase/MEKK1-dependent Activating Protein-1-mediated Promatrix Metalloproteinase-9 Activation* , 2005, Journal of Biological Chemistry.

[8]  D. Noonan,et al.  Transcriptional control of cell density dependent regulation of matrix metalloproteinase and TIMP expression in breast cancer cell lines , 2005, Thrombosis and Haemostasis.

[9]  K. Belguise,et al.  FRA-1 expression level regulates proliferation and invasiveness of breast cancer cells , 2005, Oncogene.

[10]  Qiang Shen,et al.  AP-1 blockade in breast cancer cells causes cell cycle arrest by suppressing G1 cyclin expression and reducing cyclin-dependent kinase activity , 2004, Oncogene.

[11]  Ken Jacobson,et al.  MAP kinases and cell migration , 2004, Journal of Cell Science.

[12]  Yong Pan,et al.  Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors , 2004, Oncogene.

[13]  T. Löning,et al.  The Role of the AP-1 Transcription Factors c-Fos, FosB, Fra-1 and Fra-2 in the Invasion Process of Mammary Carcinomas , 2004, Breast Cancer Research and Treatment.

[14]  A. Groyer,et al.  Disruption of MKK4 signaling reveals its tumor-suppressor role in embryonic stem cells , 2004, Oncogene.

[15]  S. Gabriel,et al.  EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy , 2004, Science.

[16]  S. Vicent,et al.  Mitogen-Activated Protein Kinase Phosphatase-1 Is Overexpressed in Non-Small Cell Lung Cancer and Is an Independent Predictor of Outcome in Patients , 2004, Clinical Cancer Research.

[17]  Patricia L. Harris,et al.  Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. , 2004, The New England journal of medicine.

[18]  R. Silverman,et al.  An Apoptotic Signaling Pathway in the Interferon Antiviral Response Mediated by RNase L and c-Jun NH2-terminal Kinase* , 2004, Journal of Biological Chemistry.

[19]  Ken Jacobson,et al.  JNK phosphorylates paxillin and regulates cell migration , 2003, Nature.

[20]  G. Mills,et al.  Evidence That Phosphatidylinositol 3-Kinase- and Mitogen-activated Protein Kinase Kinase-4/c-Jun NH2-terminal Kinase-dependent Pathways Cooperate to Maintain Lung Cancer Cell Survival* , 2003, Journal of Biological Chemistry.

[21]  N. Kennedy,et al.  Role of JNK in Tumor Development , 2003, Cell cycle.

[22]  D. Bar-Sagi,et al.  Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. , 2003, Genes & development.

[23]  A. Montag,et al.  Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma. , 2002, Cancer research.

[24]  M. Castellazzi,et al.  Transcriptional upregulation of SPARC, in response to c-Jun overexpression, contributes to increased motility and invasion of MCF7 breast cancer cells , 2002, Oncogene.

[25]  Christian A. Rees,et al.  Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[26]  G. Johnson,et al.  Signalling: Mixed-lineage kinase control of JNK and p38 MAPK pathways , 2002, Nature Reviews Molecular Cell Biology.

[27]  T. Jacks,et al.  Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[28]  Richard A. Flavell,et al.  Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts , 2002, Nature Genetics.

[29]  Ximing J. Yang,et al.  Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers. , 2001, Cancer research.

[30]  M. Gorospe,et al.  c-Jun N-terminal Kinase Is Essential for Growth of Human T98G Glioblastoma Cells* , 2000, The Journal of Biological Chemistry.

[31]  E. Bossy‐Wetzel,et al.  Cell cycle‐dependent variations in c‐Jun and JunB phosphorylation: a role in the control of cyclin D1 expression , 2000, The EMBO journal.

[32]  W. Lang,et al.  A dominant role for the c-Jun NH2-terminal kinase in oncogenic ras-induced morphologic transformation of human lung carcinoma cells. , 2000, Cancer research.

[33]  Ash A. Alizadeh,et al.  Genome-wide analysis of DNA copy-number changes using cDNA microarrays , 1999 .

[34]  O. Potapova,et al.  The Jun Kinase 2 Isoform Is Preferentially Required for Epidermal Growth Factor-Induced Transformation of Human A549 Lung Carcinoma Cells , 1999, Molecular and Cellular Biology.

[35]  T. Sasaki,et al.  Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. , 1999, Development.

[36]  R. Hruban,et al.  Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. , 1998, Cancer research.

[37]  Y. Ip,et al.  Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development. , 1998, Current opinion in cell biology.

[38]  M. Skolnick,et al.  Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. , 1997, Cancer research.

[39]  O. Potapova,et al.  The Jun Kinase/Stress-activated Protein Kinase Pathway Functions to Regulate DNA Repair and Inhibition of the Pathway Sensitizes Tumor Cells to Cisplatin* , 1997, The Journal of Biological Chemistry.

[40]  T. Mak,et al.  Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3 , 1997, Nature.

[41]  K. Sugimachi,et al.  ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis. , 1992, Cancer research.

[42]  J. Minna,et al.  Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines. , 1991, Oncogene.

[43]  C. Harris,et al.  A human bronchial epithelial cell strain with unusual in vitro growth potential which undergoes neoplastic transformation after SV40 T antigen gene transfection , 1991, International journal of cancer.

[44]  C. Harris,et al.  Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. , 1988, Cancer research.

[45]  J. Rhim,et al.  C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.