Quantitative assessment of regional pulmonary perfusion in the entire lung using three‐dimensional ultrafast dynamic contrast‐enhanced magnetic resonance imaging: Preliminary experience in 40 subjects

To assess regional differences in quantitative pulmonary perfusion parameters, i.e., pulmonary blood flow (PBF), mean transit time (MTT), and pulmonary blood volume (PBV) in the entire lung on a pixel‐by‐pixel basis in normal volunteers and pulmonary hypertension patients.

[1]  M. Welch,et al.  Measurement of regional pulmonary blood flow with PET. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[2]  G. E. Newman,et al.  Chronic multiple pulmonary emboli. Regional response of the bronchial circulation. , 1989, Investigative radiology.

[3]  G W Dean,et al.  Gravity-independent inequality in pulmonary blood flow in humans. , 1987, Journal of applied physiology.

[4]  M. Shinohara,et al.  Accuracy of deconvolution analysis based on singular value decomposition for quantification of cerebral blood flow using dynamic susceptibility contrast-enhanced magnetic resonance imaging. , 2001, Physics in medicine and biology.

[5]  H. Palevsky,et al.  Classification of Histologic Lesions in Primary Pulmonary Hypertension Group Medial lesions Intimal lesions Medial hypertrophy Increased smooth muscle , 2005 .

[6]  D. Chemla,et al.  Haemodynamic evaluation of pulmonary hypertension , 2002, European Respiratory Journal.

[7]  R R Edelman,et al.  Pulmonary perfusion: Qualitative assessment with dynamic contrast‐enhanced MRI using ultra‐short TE and inversion recovery turbo FLASH , 1996, Magnetic resonance in medicine.

[8]  S. Pass,et al.  Current and Emerging Therapy for Primary Pulmonary Hypertension , 2002, The Annals of pharmacotherapy.

[9]  A. Fishman,et al.  Nonrespiratory functions of the lungs. , 1977, Chest.

[10]  B. Rosen,et al.  Pitfalls in MR measurement of tissue blood flow with intravascular tracers: Which mean transit time? , 1993, Magnetic resonance in medicine.

[11]  B. Rosen,et al.  High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: Mathematical approach and statistical analysis , 1996, Magnetic resonance in medicine.

[12]  Hiroto Hatabu,et al.  Solitary pulmonary nodules: potential role of dynamic MR imaging in management initial experience. , 2002, Radiology.

[13]  B. Rosen,et al.  High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results , 1996, Magnetic resonance in medicine.

[14]  T. Hara,et al.  Using H2(15)O and C15O in noninvasive pulmonary measurements. , 1994, Chest.

[15]  Kenya Murase,et al.  Quantitative evaluation of mean transit times obtained with dynamic susceptibility contrast-enhanced MR imaging and with (133)Xe SPECT in occlusive cerebrovascular disease. , 2002, AJR. American journal of roentgenology.

[16]  J. Hogg,et al.  Regional pulmonary transit times in humans. , 1989, Journal of applied physiology.

[17]  T. Jones,et al.  Interrelationships between regional blood flow, blood volume, and ventilation in supine humans. , 1994, Journal of applied physiology.

[18]  J. Scott,et al.  Primary pulmonary hypertension: diagnosis, medical and surgical treatment. , 1990, Respiratory medicine.

[19]  R R Edelman,et al.  Evaluation of regional pulmonary perfusion using ultrafast magnetic resonance imaging , 2001, Magnetic resonance in medicine.

[20]  K. Zierler.  Indicator Dilution Methods for Measuring Blood Flow, Volume, and Other Properties of Biological Systems: A Brief History and Memoir , 2000, Annals of Biomedical Engineering.

[21]  L. Rubin,et al.  Primary Pulmonary Hypertension: AN ANALYSIS OF 28 CASES AND A REVIEW OF THE LITERATURE , 1986 .

[22]  M. Pistolesi,et al.  Perfusion lung imaging in the adult respiratory distress syndrome , 1986, Journal of thoracic imaging.

[23]  Y. Ohno,et al.  Contrast-enhanced MR perfusion imaging and MR angiography: utility for management of pulmonary arteriovenous malformations for embolotherapy. , 2002, European journal of radiology.

[24]  R. Lisbona,et al.  Effect of body posture on spatial distribution of pulmonary blood flow. , 1988, Journal of applied physiology.

[25]  D. Schuster.  ARDS: clinical lessons from the oleic acid model of acute lung injury. , 1994, American journal of respiratory and critical care medicine.

[26]  K. Murase,et al.  Determination of arterial input function using fuzzy clustering for quantification of cerebral blood flow with dynamic susceptibility contrast‐enhanced MR imaging , 2001, Journal of magnetic resonance imaging : JMRI.

[27]  R R Edelman,et al.  Quantitative assessment of pulmonary perfusion with dynamic contrast‐enhanced MRI , 1999, Magnetic resonance in medicine.

[28]  B. Brogdon.  Perspective on the Four-Year Residency , 1989 .

[29]  D. Buff.  Primary pulmonary hypertension. , 1987, Annals of internal medicine.

[30]  S. Lindahl,et al.  Pulmonary perfusion is more uniform in the prone than in the supine position: scintigraphy in healthy humans. , 1999, Journal of applied physiology.

[31]  K. Zierler,et al.  On the theory of the indicator-dilution method for measurement of blood flow and volume. , 1954, Journal of applied physiology.

[32]  J. Wilson,et al.  Dynamic measurement of regional ventilation and perfusion of the lung with Xe-133. , 1977, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[33]  R. Wilson,et al.  Magnetic resonance quantification of the myocardial perfusion reserve with a Fermi function model for constrained deconvolution. , 1998, Medical physics.