论文信息 - Closeout of the award DE-FG02-05ER46223. Trustees of the University of Pennsylvania. Project title- "Modular Designed Protein Constructions for Solar Generated H2 From Water

Closeout of the award DE-FG02-05ER46223. Trustees of the University of Pennsylvania. Project title- "Modular Designed Protein Constructions for Solar Generated H2 From Water

As the title of the grant clearly states, this project has explores a unique way that makes use of manmade proteins to turn solar energy into chemical fuels. A major impetus to the work is that there is growing support for the view that two related forces will impact on future livability of Earth. The first is the finite supply of fossil fuels to power the Earth making it prudent to save this resource for the creation of useful chemicals. The second is that burning fossil fuels to generate power releases “greenhouse” gases into the atmosphere. There is mounting evidence that this is a major contribution to the warming trend in the Earth’s atmosphere and biosphere.

P. Leslie Dutton

[1] R. Hochstrasser,et al. Design of amphiphilic protein maquettes: enhancing maquette functionality through binding of extremely hydrophobic cofactors to lipophilic domains. , 2005, Biochemistry.

[2] P. Dutton,et al. A Flavin Analogue with Improved Solubility in Organic Solvents. , 2007, Tetrahedron letters.

[3] P. Dutton,et al. Synthetic hydrogenases: incorporation of an iron carbonyl thiolate into a designed peptide. , 2007, Journal of the American Chemical Society.

[4] P. Dutton,et al. 15N solid-state NMR provides a sensitive probe of oxidized flavin reactive sites. , 2006, Journal of the American Chemical Society.

[5] Sarah E. Chobot,et al. Distance metrics for heme protein electron tunneling. , 2008, Biochimica et biophysica acta.

[6] P. Dutton,et al. Hydrogen bond-free flavin redox properties: managing flavins in extreme aprotic solvents. , 2008, Organic & biomolecular chemistry.