Glucose metabolism in sporadic Creutzfeldt–Jakob disease: a statistical parametric mapping analysis of 18F‐FDG PET

Background and purpose:  Reports describing functional neuroimaging techniques, such as positron emission tomography (PET) and single‐photon emission computed tomography (SPECT), in sporadic Creutzfeldt–Jakob disease (sCJD) have consistently suggested that these tools are sensitive for the identification of areas of hypoperfusion or hypometabolism, even in the early stages of sCJD. However, there are few reports on the use of [18F]fluoro‐2‐deoxy‐D‐glucose (FDG) PET in sCJD, and most of them are single case reports. Only two small cohort studies based on visual inspection or a region of interest method have been published to date. Using a statistical parametric mapping (SPM) analysis of 18F‐FDG PET, we investigated whether there are brain regions preferentially affected in sCJD.

[1]  G. Macchi,et al.  Resistance of the hippocampus in Creutzfeldt-Jakob disease. , 1997, Clinical neuropathology.

[2]  H. Budka,et al.  Unilateral Creutzfeldt‐Jakob disease , 1986, Neurology.

[3]  W. Heiss,et al.  Positron emission tomography in Creutzfeldt-Jakob disease. , 1990, Archives of neurology.

[4]  B. Barbiroli,et al.  Pathologic correlates of diffusion MRI changes in Creutzfeldt-Jakob disease , 2009, Neurology.

[5]  A. Luxen,et al.  Positron emission tomography and histopathology in Creutzfeldt‐Jakob disease , 1993, Neurology.

[6]  H. Fukuyama,et al.  Heidenhain Variant of Creutzfeldtjakob Disease: Diffusion‐Weighted MRI and PET Characteristics , 2004, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[7]  F. Aichner,et al.  Multitracer study in Heidenhain variant of Creutzfeldt-Jakob disease: mismatch pattern of cerebral hypometabolism and perfusion imaging. , 2008, Neuro endocrinology letters.

[8]  P. Garcia,et al.  Correlating DWI MRI With Pathologic and Other Features of Jakob-Creutzfeldt Disease , 2009, Alzheimer disease and associated disorders.

[9]  R. Hilker,et al.  Multitracer PET imaging in Heidenhain variant of Creutzfeldt–Jakob disease , 2005, Journal of Neurology.

[10]  J. Ruhlmann,et al.  18F-fluorodeoxyglucose-PET and99mTc-bicisate-SPECT in Creutzfeldt-Jakob disease , 1996, Annals of nuclear medicine.

[11]  S. Prusiner,et al.  Bitemporal hypometabolism in Creutzfeldt-Jakob disease measured by positron emission tomography with [18F]-2-fluorodeoxyglucose. , 1984, Journal of computer assisted tomography.

[12]  C. Begue,et al.  Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease , 2009, Brain : a journal of neurology.

[13]  J. Parisi,et al.  A 54-year-old man with slowness of movement and confusion , 2007, Neurology.

[14]  Hideo Tsukada,et al.  Multitracer study with positron emission tomography in Creutzfeldt-Jakob disease , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[15]  A. Drzezga,et al.  Positron emission tomography with [18F]FDG in the diagnosis of Creutzfeldt-Jakob disease (CJD) , 2002, Journal of Neurology.

[16]  Michael P. Alexander,et al.  Creutzfeldt‐Jakob disease presenting as isolated aphasia , 1989, Neurology.

[17]  G. Worrell,et al.  Lateralized and focal clinical, EEG, and FLAIR MRI abnormalities in Creutzfeldt–Jakob disease , 2003, Clinical Neurophysiology.

[18]  B. Steinhoff,et al.  The Heidenhain variant of Creutzfeldt-Jakob disease. , 1999, Archives of neurology.

[19]  H. Urbach,et al.  Pattern of Cortical Changes in Sporadic Creutzfeldt-Jakob Disease , 2007, American Journal of Neuroradiology.

[20]  M. Westover,et al.  Premortem Diagnosis of Sporadic Creutzfeldt-Jakob Disease Aided by Positron-Emission Tomography Imaging , 2010, American Journal of Neuroradiology.

[21]  Jae-Il Kim,et al.  Association of sporadic Creutzfeldt–Jakob disease with homozygous genotypes at PRNP codons 129 and 219 in the Korean population , 2005, Neurogenetics.

[22]  J. Adair,et al.  Diffusion-weighted magnetic resonance imaging in probable Creutzfeldt-Jakob disease: a clinical-anatomic correlation. , 1999, Archives of neurology.

[23]  H. Urbach,et al.  MRI in sporadic Creutzfeldt-Jakob disease: Correlation with clinical and neuropathological data , 1998, Neuroradiology.

[24]  Peter B Kingsley,et al.  Correlation of diffusion-weighted magnetic resonance imaging with neuropathology in Creutzfeldt-Jakob disease. , 2002, Archives of neurology.

[25]  Y. Itoyama,et al.  Diffusion-weighted MRI abnormalities as an early diagnostic marker for Creutzfeldt–Jakob disease , 2004, Neurology.

[26]  T. Sato,et al.  Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease , 2005, Neurology.

[27]  C. Tegeler,et al.  Asymmetric Neuroimaging in Creutzfeldt‐Jakob Disease: A Ruse , 2003, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[28]  A. Pénicaud,et al.  MRI and FDG PET/CT findings in a case of probable Heidenhain variant Creutzfeldt-Jakob disease. , 2008, Journal of neuroradiology. Journal de neuroradiologie.

[29]  D. Galanaud,et al.  MRI lesion profiles in sporadic Creutzfeldt–Jakob disease , 2009, Neurology.

[30]  B. Miller,et al.  Diffusion-weighted and fluid-attenuated inversion recovery imaging in Creutzfeldt-Jakob disease: high sensitivity and specificity for diagnosis. , 2005, AJNR. American journal of neuroradiology.

[31]  A. Alavi,et al.  Photo essay. MRI and positron emission tomography findings in Heidenhain variant Creutzfeldt-Jakob disease. , 2010, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.

[32]  K. Arima,et al.  Prion disease causes less severe lesions in human hippocampus than other parts of brain , 2008, Psychiatry and clinical neurosciences.

[33]  H. Engler,et al.  Multitracer study with positron emission tomography in Creutzfeldt-Jakob disease , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[34]  R. Henry,et al.  Diffusion-weighted MRI hyperintensity patterns differentiate CJD from other rapid dementias , 2011, Neurology.

[35]  A. Kirk,et al.  Unilateral Creutzfeldt-Jakob Disease Presenting as Rapidly Progressive Aphasia , 1994, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.