Oncogenicity by Methyl Methanesulfonate in Male RF Mice

The incidences of lung tumors and thymic lymphomas were increased in young adult male RF mice receiving 30 milligrams of methyl meth anesulfonate per kilogram of body weight daily in the drinking water throughout life. Differences in oncogenicity between treatment with methyl methanesulfonate and with dimethylnitrosamine or diethylnitrosamine suggest a qualitative difference between the site (or sites) of alkylation by methyl methanesulfonate and by dimethylnitrosamine or diethylnitrosamine within the nucleic acids.

[1]  A. Craig,et al.  Carcinogenic effects of diethylnitrosamine in RF mice. , 1967, Journal of the National Cancer Institute.

[2]  V. Craddock.  REACTION OF THE CARCINOGEN DIMETHYLNITROSAMINE WITH PROTEINS AND WITH THIOL COMPOUNDS IN THE INTACT ANIMAL. , 1965, The Biochemical journal.

[3]  P. D. Lawley,et al.  REACTION OF SOME MUTAGENIC AND CARCINOGENIC COMPOUNDS WITH NUCLEIC ACIDS. , 1964, Journal of cellular and comparative physiology.

[4]  P. Magee,et al.  Cellular injury and carcinogenesis. Alkylation of ribonucleic acid of rat liver by diethylnitrosamine and n-butylmethylnitrosamine in vivo. , 1964, The Biochemical journal.

[5]  P. D. Lawley,et al.  EFFECTS OF ALKYLATING AGENTS ON T2 AND T4 BACTERIOPHAGES. , 1963, The Biochemical journal.

[6]  T. McDonald,et al.  Comparative late somatic effects of some radiomimetic agents and x-rays. , 1963, Radiation research.

[7]  A. Craig,et al.  Antifertility substances and their assessment in the male rodent. , 1961, Journal of reproduction and fertility.

[8]  A. Upton,et al.  Leukemogenic Effect of Myleran on the Mouse Thymus , 1961, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[9]  J. Burney.  Chronological history of north-eastern voyages of discovery , 1969 .

[10]  P. Magee,et al.  METHYLATION OF RIBONUCLEIC ACIDS OF LIVER AND OTHER ORGANS IN DIFFERENT SPECIES TREATED WITH C14- AND H3-DIMETHYLNITROSAMINES IN VIVO. , 1964, Journal of the National Cancer Institute.