相关论文
2014 - International Journal of Urban Sciences
A study on the impact of soft location factors in the relocation of service and manufacturing firms

This paper empirically studied relocation factors for manufacturing and service firms in the Seoul Metropolitan Area. The purpose of this study is to identify the influence not only of traditional firm location factors, but also of quality of life factors. A firm's location decision is an assertive action (behaviour) to maximize profit that may have a large ripple effect on the regional economy and society. This study used a binary logit model to analyse location choice factors during firm relocations. As of December 2011, the number of firms registered with the Korea Chamber of Commerce and Industry was 117,157. Of these firms, 36,598 were selected. The firms’ locations could be tracked because their names and owners did not change from December 2006 to December 2012. Of the selected firms, 8328 (22.8%) relocated during this period. It can be considered that 4.6% of all firms relocate in a year. A geographic information system database was built using location addresses of the 8328 firms. This study exhibited a trend that manufacturing firms moved from cities to suburbs, where transport and industry conditions were more favourable. By contrast, firms in higher-order industries with high-added value moved to city centres, where living conditions were more favourable. This trend suggests that quality of life factors have become more important in firm location decisions. This study is expected to be used to understand changes in firm locations and relocations, and to help make industrial policies for drawing firms.

2016 - Microeconomics: Asymmetric & Private Information eJournal
Optimal Contracting in Networks

We study optimal contracting between a firm selling a divisible good that exhibits positive externality and a group of agents in a social network. The extent of externality that each agent receives from the consumption of neighboring agents is privately held and is unknown to the firm. By explicitly characterizing the optimal multilateral contract, we demonstrate how inefficiency in an agent’s trade propagates through the network and creates unequal and network-dependent downward distortion in other agents’ trades. Furthermore, we describe bilateral contracts (non-linear pricing schemes) and characterize their explicit dependence on the network structure. We show that the firm will benefit from uncertainty in an agent’s valuation of other agents’ externality. We describe the profit gap between multilateral and bilateral con- tracts and analyze the consequences of the explicit dependence of the contracts on network structure. When the network is balanced in terms of homogeneity of agents’ influence, network structure has no impact on the firm’s profit for bilateral contracts. On the other hand, when the influences are heterogeneous with high dispersion (as in core-periphery networks) the restriction to bilateral contracts can result in profit losses that grow unbounded with the size of networks.

2005 - Naval Research Logistics
Project scheduling under competition

We introduce and investigate the problem of scheduling activities of a project by a firm that competes with another firm (the competitor) that has to perform the same project. The profit that the firm gets from each activity depends on whether the firm finishes the activity before or after its competitor. The objective is to maximize the guaranteed (worst-case) profit. We assume that both the firm and the competitor can perform only one activity at a time. We perform a detailed complexity analysis of the problem, and consider problems with and without precedence constraints, with and without delay of the competitor, with general and equal processing times of activities. For polynomially solvable cases (which include, for example, all the considered problems without delay of the competitor), we present easily implementable and intuitive rules that allow us to obtain optimal schedules in linear or almost linear time. For some NP-hard cases, we present pseudopolynomial algorithms and fast heuristics with worst-case approximation guarantees. © 2005 Wiley Periodicals, Inc. Naval Research Logistics, 2005.

2000 - Journal of the Learning Sciences
Inscribing the Winch: Mechanisms by Which Students Develop Knowledge Structures for Representing the Physical World With Algebra

I propose and test an account of mechanisms by which students develop knowledge structures for modeling the physical world with algebra. The account begins to bridge the gap between current mathematics curricula, in which modeling activities play an important role, and theoretical accounts of how students learn to model, which lag behind. After describing the larger study, in which I observed 12 pairs of 8th-grade students introduce and refine algebraic representations of a physical device called a winch, I then focus on 1 pair that generated an unconventional yet sound equation. Because the prevailing genetic accounts of knowledge structures in mathematics education, cognitive science, and information-processing psychology do not explain key characteristics of the data, I begin to construct a new developmental account that does. To do so, I use forms, a class of schemata that combine patterns of algebra symbols with patterns of experience in the physical world, and 2 mechanisms, notation variation and mapping variation. I then use forms and the 2 mechanisms to analyze how the selected pair of students introduced and refined initial, faulty algebraic representations of the winch into an unconventional yet sound equation.

2013
Effects of ZnO film growth route and nanostructure on electron transport and recombination in dye-sensitized solar cells

The photovoltaic performances of ZnO-based dye-sensitized solar cells (DSSCs) have been studied for ZnO porous films prepared by different techniques. A comparison is made between nanoparticle (NP) films prepared by a sol–gel method and two different electrodeposited (ED) nanoporous films. The D149 indoline dye/ZnO with ZnO prepared by electrochemistry at rather high overvoltage has been found to be the best system. The cell functioning has been studied in-depth by electrochemical impedance spectroscopy (EIS) measurements made over a large potential range, in the dark and under illumination. It is shown that a much deeper sub-conduction band edge density of states (DOS) exists in the case of NP cells compared to ED cells. The electron dynamics have been analysed by determining the charge carrier lifetimes and transport/collection times. In the case of NP films, the charge carrier behaviour is characterized by rather long lifetimes and transport times with a marked voltage response typical of conduction that is governed by trapping–detrapping events. On the contrary, in the case of electrodeposited films, these two parameters are much shorter and the transport is characterized by a straight charge transport. Using photoluminescence data, the charge carrier lifetimes have been related to the surface defects of the ZnO nanostructures. The deduced electron collections were found to be very efficient with values greater than 90%. We have also determined that the ZnO film conductivities were higher than for anatase TiO2, and that the electron diffusion coefficient was higher in the ED film compared to the NP film.

2019 - IEEE Transactions on Engineering Management
An Analysis of Open Innovation Strategies in Firms in Low and Medium Technology Industries

Open innovation (OI) has been mainly associated with high-technology firms. This paper aims to analyze how firms in low and medium technology industries implement their OI strategy. In doing so, we explore common patterns in OI strategies by considering inbound, outbound, and coupled OI practices. We also examine whether there are differences in innovation performance among companies adopting a specific OI strategy. The study is carried out on a sample of 242 Spanish innovating companies. Based on the relevance of the different OI practices, we identify three types of OI firms: advanced open innovators, intermediate open innovators, and incipient open innovators. Our results reveal that advanced open innovators have a higher performance in product innovation, and that there are no differences among groups in process and organizational innovation.

2009 - PLoS Computational Biology
Recombination Rate and Selection Strength in HIV Intra-patient Evolution

The evolutionary dynamics of HIV during the chronic phase of infection is driven by the host immune response and by selective pressures exerted through drug treatment. To understand and model the evolution of HIV quantitatively, the parameters governing genetic diversification and the strength of selection need to be known. While mutation rates can be measured in single replication cycles, the relevant effective recombination rate depends on the probability of coinfection of a cell with more than one virus and can only be inferred from population data. However, most population genetic estimators for recombination rates assume absence of selection and are hence of limited applicability to HIV, since positive and purifying selection are important in HIV evolution. Yet, little is known about the distribution of selection differentials between individual viruses and the impact of single polymorphisms on viral fitness. Here, we estimate the rate of recombination and the distribution of selection coefficients from time series sequence data tracking the evolution of HIV within single patients. By examining temporal changes in the genetic composition of the population, we estimate the effective recombination to be ρ = 1.4±0.6×10−5 recombinations per site and generation. Furthermore, we provide evidence that the selection coefficients of at least 15% of the observed non-synonymous polymorphisms exceed 0.8% per generation. These results provide a basis for a more detailed understanding of the evolution of HIV. A particularly interesting case is evolution in response to drug treatment, where recombination can facilitate the rapid acquisition of multiple resistance mutations. With the methods developed here, more precise and more detailed studies will be possible as soon as data with higher time resolution and greater sample sizes are available.

1962 - Advances in Genetics
Linkage and Recombination in Evolution

Publisher Summary This chapter discusses the linkage and recombination in evolution. The discovery of large amounts of naturally occurring genetic variability is one of the most striking features of modern evolutionary studies. The immediate fitness of a species depends on a certain uniformity of the genotype whereas long-term survival depends on the production of adequate genetic variability. The diverse environmental agencies alter recombination and interference. Maternal age and sex also affect recombination. Artificia1 alteration of the genetic background by selection or inbreeding frequently changes recombination. In micro-organisms, diverse alternatives to the sexual system exist for the promotion of genetic recombination, such as transduction, transformation, and the quasi-sexual mating system of Escherichia coli and the parasexual cycle of the filamentous fungi. These systems provide ample opportunity for recombination. In some microorganisms, cases of linked blocks of genes controlling closely related biochemical reactions occur. Classical linkage experiments were done under diverse environmental conditions and differing genetic backgrounds provide abundant evidence for the variability of recombination. The effect of temperature on recombination is the best studied variable. Recombination frequencies and chiasma frequencies are affected by differences of temperature, age, genetic background, and other variables.

1978 - Social Networks
A structural theory of interlocking corporate directorates

Abstract A theory is proposed that explains where interlocking corporate directorates should appear between sectors of an economy, where they should not appear, and the profitability of efficient corporate interlocking. Taking the sector of an economy as the unit of analysis, interlocking directorates are cast as strategically created constraints on those sectors of the economy most “problematic” for obtaining profits in a given industry of firms. The extent to which each sector of the American economy is problematic for obtaining profits in two-digit and four-digit manufacturing industries is estimated from research linking industry profits with the form of the pattern of relations defining the industry as a position in the network of dollar flow transactions given in the 1967 Input-Output Study for the United States. A two-stage process is described for sampling firms representative of large corporations involved in American manufacturing. Measures of alternative strategies for interlocking across sectors are described. Two classes of hypotheses are derived: (1) Firms in an industry should interlock with firms in some other sector in proportion to the extent to which the sector constrains the industry's profits. (2) Controlling for production and market differences, the ability of firms in an industry to obtain unusually high profits reflects their success in creating interlocks with those sectors most problematic for their industry's profits.

1997 - Journal of Corporate Finance
The Effect of Stock Splits on the Ownership Structure of Firms

Although several researchers have speculated that stock splits may affect the ownership structure of firms, there is very little empirical evidence available in this regard. We investigate a broad sample of stock splits by firms without confounding events, controlling for industry and size effects. Our results show that stock splits increase the numbers of both individual and institutional shareholders, and they do not affect the proportion of equity held by institutions. Further, changes in the numbers of individual and institutional shareholders are positively related to the split factor. Abnormal announcement returns are positively correlated with changes in the total number of shareholders. These findings support the signaling hypothesis.

2011 - Int. J. Account. Inf. Syst.
Impact of enterprise resource planning systems on management control systems and firm performance

In this study, we extend existing research on enterprise resource planning systems by exploring the effects of enterprise system adoption on subsequent non-financial and financial performance of a firm. Specifically, we investigate the role of formal and informal management control systems as mechanisms which mediate the effect of enterprise resource planning systems adoption on firm performance. Our empirical analyses are based on survey data drawn from 70 Finnish business units. Overall, our findings demonstrate that formal types of management control systems act as intervening variables mediating the positive lagged effect between enterprise systems adoption and non-financial performance. Informal types of management control systems, however, do not show similar mediating effects. We also predict and find a significant relationship between non-financial and financial firm performance. These results are important because the evidence on the joint roles of enterprise systems and management control system on improving the firm performance is very limited in prior literature. Our results show that the use of enterprise systems results in improved firm performance in the long run, and that more formal than informal types of management controls help firms achieve future performance goals.

2008 - Genome research
Confounding between recombination and selection, and the Ped/Pop method for detecting selection.

In recent years, there have been major developments of population genetics methods to estimate both rates of recombination and levels of natural selection. However, genomic variants subject to positive selection are likely to have arisen recently and, consequently, had less opportunity to be affected by recombination. Thus, the two processes have an intimately related impact on genetic variation, and inference of either may be vulnerable to confounding by the other. We illustrate here that even modest levels of positive selection can substantially reduce population-based recombination rate estimates. We also show that genome-wide scans to detect loci under recent selection in humans have tended to highlight loci in regions of low recombination, suggesting that confounding by recombination rate may have reduced the power of these studies. Motivated by these findings, we introduce a new genome-wide approach for detecting selection, based on the ratio of pedigree-based to population-based estimates of recombination rate. Simulations suggest that our "Ped/Pop" method, which is designed to capture completed sweeps, has good power to discriminate between neutral and adaptive evolution. Unusually for a multimarker method, our approach performs well in regions of high recombination and also has good power for many generations after the fixation of an advantageous variant. We apply the method to human HapMap and Perlegen data sets, finding confirmation of reported candidates as well as identifying new loci that may have undergone recent intense selection.

2010 - PLoS genetics
Human Population Differentiation Is Strongly Correlated with Local Recombination Rate

Allele frequency differences across populations can provide valuable information both for studying population structure and for identifying loci that have been targets of natural selection. Here, we examine the relationship between recombination rate and population differentiation in humans by analyzing two uniformly-ascertained, whole-genome data sets. We find that population differentiation as assessed by inter-continental F ST shows negative correlation with recombination rate, with F ST reduced by 10% in the tenth of the genome with the highest recombination rate compared with the tenth of the genome with the lowest recombination rate (P≪10−12). This pattern cannot be explained by the mutagenic properties of recombination and instead must reflect the impact of selection in the last 100,000 years since human continental populations split. The correlation between recombination rate and F ST has a qualitatively different relationship for F ST between African and non-African populations and for F ST between European and East Asian populations, suggesting varying levels or types of selection in different epochs of human history.

1995 - American journal of human genetics
Molecular mapping of a recombination hotspot located in the second intron of the human TAP2 locus.

Recombination across the HLA class II region is not randomly distributed, as indicated by both strong linkage disequilibrium within the 100 kb encompassing the DRB1-DQA1-DQB1 loci and complete equilibrium between TAP1 and TAP2, the closest variant sites of which are < 15 kb. In an attempt to explain these observations, 39 novel polymorphic markers in a region encompassing the TAP, LMP, and DOB genes were used to delineate the site of crossover in 11 class II recombinant chromosomes. SSCP demonstrated that two recombination events occurred within an 850-bp interval in the second intron of TAP2, which separates the variant sites of TAP1 and TAP2. These data indicate the presence of a recombination hotspot, the first to be identified from the analysis of familial transmission in the human major histocompatibility complex. The region of crossover was cloned and sequenced from one of the recombinants, further defining the crossover site to a 138-bp segment nested within the 850-bp region. This represents the most precisely defined region of recombination in the human genome.

1983 - Journal of Accounting and Economics
Taxes and firm size

Abstract Firm size has been used as a proxy for the firm's political costs and hence managers' proclivity to choose income reducing accounting procedures. This study provides additional evidence on this topic by examining the association between firm size and effective corporate tax rates. The latter are one component of a firm's political costs. The roughly fifty largest U.S. exchange-listed firms, in particular oil and gas companies and manufacturing firms, have significantly higher worldwide tax rates than other firms. These higher tax rates are observed primarily after the implementation of the U.S. 1969 Tax Reform Act and after the OPEC countries raised their tax rates on U.S. oil producers. The findings, which are insensitive to alternative sources of data, alternative measures of firm size, and alternative measures of effective tax rates, are consistent with the use in previous studies of firm size as a proxy for the firm's political costs.

1995 - Journal of Financial Economics
Equity ownership and the two faces of debt

We empirically investigate the relation between corporate value, leverage, and equity ownership. For ‘high-growth’ firms corporate value is negatively correlated with leverage, whereas for ‘low-growth’ firms corporate value is positively correlated with leverage. The results also hint that the allocation of equity ownership among insiders, institutions, blockholders, and atomistic outside shareholders is of marginally greater significance in low-growth than in high-growth firms. The overall interpretation of the results is that debt policy and equity ownership structure ‘matter’ and that the way in which they matter differs between firms with many and firms with few positive net present value projects.

2009 - PLoS genetics
Mu Transposon Insertion Sites and Meiotic Recombination Events Co-Localize with Epigenetic Marks for Open Chromatin across the Maize Genome

The Mu transposon system of maize is highly active, with each of the ∼50–100 copies transposing on average once each generation. The approximately one dozen distinct Mu transposons contain highly similar ∼215 bp terminal inverted repeats (TIRs) and generate 9-bp target site duplications (TSDs) upon insertion. Using a novel genome walking strategy that uses these conserved TIRs as primer binding sites, Mu insertion sites were amplified from Mu stocks and sequenced via 454 technology. 94% of ∼965,000 reads carried Mu TIRs, demonstrating the specificity of this strategy. Among these TIRs, 21 novel Mu TIRs were discovered, revealing additional complexity of the Mu transposon system. The distribution of >40,000 non-redundant Mu insertion sites was strikingly non-uniform, such that rates increased in proportion to distance from the centromere. An identified putative Mu transposase binding consensus site does not explain this non-uniformity. An integrated genetic map containing more than 10,000 genetic markers was constructed and aligned to the sequence of the maize reference genome. Recombination rates (cM/Mb) are also strikingly non-uniform, with rates increasing in proportion to distance from the centromere. Mu insertion site frequencies are strongly correlated with recombination rates. Gene density does not fully explain the chromosomal distribution of Mu insertion and recombination sites, because pronounced preferences for the distal portion of chromosome are still observed even after accounting for gene density. The similarity of the distributions of Mu insertions and meiotic recombination sites suggests that common features, such as chromatin structure, are involved in site selection for both Mu insertion and meiotic recombination. The finding that Mu insertions and meiotic recombination sites both concentrate in genomic regions marked with epigenetic marks of open chromatin provides support for the hypothesis that open chromatin enhances rates of both Mu insertion and meiotic recombination.

2017 - Management Decision
Open innovation and intellectual property rights: How do SMEs benefit from patents, industrial designs, trademarks and copyrights?

Purpose The purpose of this paper is to study the relationship between open innovation and the use of intellectual property rights (IPRs) in small- and medium-sized enterprises (SMEs). The authors consider patents, industrial designs (i.e. design patents in the USA), trademarks, and copyrights. Design/methodology/approach The relationships between open innovation, IPRs, and profitability are tested with random-effects panel regressions on data from the Spanish Community Innovation Survey for 2,873 firms spanning the years 2008-2013. Findings A key result is that SMEs do not benefit from open innovation or from patenting in the same way as larger firms. Furthermore, the results show that SMEs profit in different ways from IPR, depending on their size and the corresponding IPR. Research limitations/implications The different impact of IPRs on the efficiency of open innovation in firms of varying sizes highlights the importance of further investigation into IP strategies and into open innovation in SMEs. Practical implications Industrial designs are currently the most efficient IPR for SMEs to protect their intellectual property in open innovation collaborations. Depending on the company size, the use of different IPRs is recommended. Moreover, firms should seek to increase the efficiency of open innovation and the use of IPRs. Social implications The high impact of SMEs on employment highlights the importance of fomenting efficient innovation processes in such firms. Originality/value This paper opens the black box of IPR in relation to open innovation in SMEs, and draws distinctive conclusions with regards to patents, industrial designs, trademarks, and copyrights.

2011
Organizing Continuous Product Development and Commercialization: The Collaborative Community of Firms Model

The increased importance of knowledge creation and use to firms’ global competitiveness has spawned considerable experimentation with organizational designs for product development and commercialization over the last three decades. This paper discusses innovation-related organizational design developments during this period, showing how firms have moved from stand-alone organizations to multifirm network organizations to community-based organizational designs. The collaborative community of firms model, the most recent organizational design in this evolutionary process, is described in detail. Blade.org, a purposefully designed collaborative community of firms dedicated to the continuous development and commercialization of blade servers, a computer technology with large but unforeseeable market potential, is used as an illustrative case. Blade.org’s organizational design combines a community ‘‘commons’’ for the collective development and sharing of knowledge among member firms with explicit institutional mechanisms for the support of direct intermember collaboration. These design elements are used to overcome the challenges associated with (1) concurrent technological and market experimentation and (2) the dynamic coordination of a complex emergent system of hardware, software, and services provided by otherwise independent firms. To date, Blade.org has developed more than 60 new products, providing strong evidence of the innovation prowess of the collaborative community of firms organizational model. Based on an analysis of the evolution of organizational designs and the case of Blade.org, implications for innovation management theory and practice are derived.

2012
Entrepreneurship and open innovation in an emerging economy

Purpose – The purpose of the paper is to examine the performance of firms in Peru in relation to entrepreneurial orientation and involvement in open innovation.Design/methodology/approach – Data were acquired through a survey of middle and senior managers employed in Peruvian companies.Findings – Firms achieving higher sales growth did not exhibit more of an entrepreneurial orientation or utilize a double loop learning style. More entrepreneurial firms appear to have adopted a double loop learning approach to knowledge acquisition. Peruvian firms involved in open innovation reported higher sales growth and indicated greater reliance on the use of double loop learning.Practical implications – The practical implications of the study are that firms in emerging economies do not have to be reliant on entrepreneurial behaviour to sustain business growth. Nevertheless involvement in open innovation can be beneficial.Originality/value – The originality of this paper is that although the results are only for compa...

Resource recombinations in the firm: knowledge structures and the potential for schumpeterian innovation

M. Tushman
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Peter Moran
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Simon Rodan
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D. C. Galunic
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Jean-Claude Thoenig
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J. Weeks
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C. Galunic
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Karel O. Cool
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J. Santos
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Rodney L. White

Abstract:Building on the resource-based view of the firm, this paper explores the notion of ‘resource recombinations’ within the firm. We suggest such recombinations can occur when competencies within the firm (which are interpreted as organized clusters of firm resources) either combine to synthesize novel competencies (synthesis-based recombinations) or experience a reconfiguration or relinking with other competencies (reconfiguration-based recombinations). Central to this paper is an examination of the antecedents necessary for such innovation to occur, and in particular the nature of knowledge in the firm. We argue that several characteristics of knowledge (tacitness, context specificity, dispersion) and its social organization (the way competencies come to be formed and institutionalized) will have important consequences on the likelihoods of resource recombinations. Our paper develops a model of resource recombination likelihoods and propositions. © 1998 John Wiley & Sons, Ltd.

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