相关论文
2014
The method of virtual machine migration management, device and system

Embodiments of the present invention, according to a plurality of migration parameters of the virtual machine migration plan, requires the virtual machine of the migration plan from the migration-source computing node in order to migrate into the migration destination computing node phase and the current available migration comprising the steps of: obtaining separately the current available migration time of the time and the migration destination computing node, the migration source computing node migration source computing node to calculate the a migration time It is currently available migration time of the current available migration time and the migration destination computing node If the deviation is also more migration hours, and a step of determining a virtual machine migration plan from the migration-source computing node to migrate into the migration destination computing node, the plurality of migration parameters, virtual migration plan machine allocation memory size, the memory changing speed, and disclose the virtual machine migration management method comprising the migration network bandwidth. Embodiments of the present invention further discloses a device and system for virtual machine migration management. By utilizing the present invention, determination of the precision of the virtual machine migration can be improved to some extent.

2014
EMPIRICAL STUDY ON OFFLINE VS LIVE MIGRATION

Virtualization is a state-of-the-art technology facilitating resource optimizations by providing an environment conducive to execute as many VMs as possible. The proliferation of VMs on a physical server makes the resource management convoluted. This difficulty in managing the resources results in these VMs not to perform optimally and seldom demonstrate poor performance. Often this underperformance may result in the VM to fail and stop working. Hence, it becomes necessary to migrate a VM from a source to a destination. When the migration decision has been taken, it becomes necessary to analyze the performance of applications during migration since all the applications will not exhibit the same performance during migration. The Migration can be conducted offline or live. This paper aims at analyzing the performance of offline and live migration techniques with respect to total migration time, downtime and performance of an application during migration.

2019
An Economic Instrument to Improve Migration

The Naturally Optimised Revenue Demand in Communities (NORDIC) model is employed to improve migration. The proposed model produces constructed shadow costs to be inserted into the public budgets to induce economic incentives to improve the integration of immigrants. The resulting shadow cost, and its impact on the PSBR, constitutes a single, key factor that by one digit only expresses how successful the integration is over time. The human tolerance is encapsulated in the launched model through a single factor in the NORDIC model equation that considers the population's general acceptance of immigrants that affects the result. Particularly, the case study shows how refugees should be better integrated into the Swedish society by application of the NORDIC model. The results point at a promising methodology for successfully integrating migrants by using economic instruments. The major conclusion is that the NORDIC model can be used for improving the immigration to a nation. In particular, the suitable level of refugee-reception is possible to determine by employing the NORDIC model in a societal context to improve a nation’s GDP and the citizens’ welfare. Possible end users are the migration-authorities and politicians that want a comprehensive tool to improve the efficiency of the reception of immigrants and refugees to the current nation. Recommendations for the use of the proposed model are given and further research suggested.

2017 - Anti-Cancer Agents in Medicinal Chemistry
Inhibitory Effects of Novel SphK2 Inhibitors on Migration of Cancer Cells.

BACKGROUND Cell migration is an essential process for survival and differentiation of mammalian cells. Numerous diseases are induced or influenced by inappropriate regulation of cell migration, which plays a key role in cancer cell metastasis. In fact, very few anti-metastasis drugs are available on the market. SphKs are enzymes that convert sphingosine to sphingosine-1-phosphate (S1P) and are known to control various cellular functions, including migration of cells. In human, SphK2 is known to promote apoptosis, suppresses cell growth, and controls cell migration; in addition, the specific ablation of SphK2 activity was reported to inhibit cancer cell metastasis. OBJECTIVE The previously identified SG12 and SG14 are synthetic analogs of sphingoid and can specifically inhibit the functions of SphK2. We investigated the effects of the SphK2 specific inhibitors on the migratory behavior of cells. METHOD We investigated how SG12 and SG14 affect cell migration by monitoring both cumulative and individual cell migration behavior using HeLa cells. RESULTS SG12 and SG14 mutually showed stronger inhibitory effects with less cytotoxicity compared with a general SphK inhibitor, N,N-dimethylsphingosine (DMS). The mechanistic aspects of specific SphK2 inhibition were studied by examining actin filamentation and the expression levels of motility-related genes. CONCLUSION The data revealed that SG12 and SG14 resemble DMS in decreasing overall cell motility, but differ in that they differentially affect motility parameters and motility-related signal transduction pathways and therefore actin polymerization, which are not altered by DMS. Our findings show that SphK2 inhibitors are putative candidates for anti-metastatic drugs.

2016
Transalkylation and Migration of N‐Substituent upon Alkylation of 1,2,3‐Triazoles Containing Good Leaving N‐Substituents

The synthesis of four new 1,2,3-triazole derivatives and seven 1,2,3-triazolium salts that contain an organometallic group (i.e., cymantrenyl and ferrocenyl) at either the N-1, N-2, or N-3 position was realized. The alkylation of organometallic and organic triazole derivatives was investigated, and as a result of these studies, it was found that the presence of a good leaving group at the heterocyclic nitrogen atom led to transalkylation and subsequent migration of the N-1 substituent to the N-2 position of the triazole moiety. The nucleophilicity of the counterion of the triazolium salt influenced the transalkylation and isomerization processes, which suggests that the elimination of the N-substituent most likely occurs though a concerted mechanism with nucleophilic assistance from the counterion. Thus, a new approach to the synthesis of 2,4-disubstituted 1,2,3-triazoles has been developed.

2016 - International Journal of Computer Applications
Energy Aware Virtual Machine Migration Techniques for Cloud Environment

Cloud Computing offers indispensable infrastructure for storage and computing facilities for development of diversified services. The large utilization of resources leads to increased energy consumption that has imposed a limit on performance growth. Owing to high operational costs and carbon dioxide footprints, an efficient energy management technique needs to be developed and deployed that reduces overall energy consumption of a cloud environment while maximizing the resource utilization. In the first phase of this research, some virtual machine migration techniques were explored. In the second phase, a virtual machine migration technique has been implemented which aims at reducing energy consumption in cloud datacentres. General Terms Virtual Machine Migration, Bin Packing Algorithms.

2016 - Genetics and Molecular Research
Effect of IL-17 monoclonal antibody Secukinumab combined with IL-35 blockade of Notch signaling pathway on the invasive capability of hepatoma cells.

We investigated the effect of the IL-17 monoclonal antibody Secukinumab combined with IL-35 in the blockade of the Notch signaling pathway on the invasive capability of hepatoma cells. We examined the effects of IL-17 antibody or IL-35 treatment alone or in combination on cell invasion and migration capabilities with Transwell chambers. The mRNA levels of Hes1, Hes5, and Hey1 were tested using quantitative polymerase chain reaction. The protein expression of N1ICD, Snail, and E-cadherin protein expressions were measured with western blot. The expression of Hes1, Hes5, Hey1 and N1ICD were all very high in hepatoma cell lines, and were positively correlated with the invasive migration capabilities of the cells. The combination of IL-17 monoclonal antibody Secukinumab with IL-35 could effectively inhibit the Notch signaling pathway, as well as the invasive migration of the cells. Snail and E-cadherin are involved in the migration of hepatoma cells, and it has been established that Snail can regulate the expression of E-cadherin. IL-17 monoclonal antibody Secukinumab combined with IL-35 can increase E-cadherin and decrease Snail expression, which are positively correlated with cell invasive migration capabilities. Overall, treatment with both IL-17 antibody and IL-35 is more effective than each treatment alone. Notch signaling is activated in hepatoma cell lines and increases with the enhancement of cell invasive migration capabilities. IL-17 monoclonal antibody Secukinumab combined with IL-35 can block the Notch signaling pathway, simultaneously reducing the invasive migration capability of hepatoma cells.

2005 - Journal of contaminant hydrology
Unidirectional gas flow in soil porosity resulting from barometric pressure cycles.

During numerical simulation of air flow in the vadose zone, it was noticed that a small sinusoidal pressure would cause a gradual one-way migration of the pore gas. This was found to be a physical phenomenon, not a numerical artifact of the finite element simulation. The one-way migration occurs because the atmospheric pressure, and hence the air density, is slightly greater when air is flowing into the ground than when air is flowing out of the ground. A simple analytic theory of the phenomenon is presented, together with analytic calculations using actual barometric pressure data. In soil of one Darcy permeability, the one-way migration is of the order of a few tenths of a meter per year for either plane flow from ground surface or for radial flow from an open borehole. The migration is sufficiently small that it will have no practical consequences in most circumstances; however, investigators who conduct detailed numerical modeling should recognize that this phenomenon is not a numerical artifact in an apparently linear system.

2014 - Mediators of Inflammation
Sphingosine-1-phosphate/S1P Receptors Signaling Modulates Cell Migration in Human Bone Marrow-Derived Mesenchymal Stem Cells

The recruitment of bone marrow-derived mesenchymal stem cells (BMSCs) to damaged tissues and sites of inflammation is an essential step for clinical therapy. However, the signals regulating the motility of these cells are still not fully understood. Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, is known to have a variety of biological effects on various cells. Here, we investigated the roles of S1P and S1P receptors (S1PRs) in migration of human BMSCs. We found that S1P exerted a powerful migratory action on human BMSCs. Moreover, by employing RNA interference technology and pharmacological tools, we demonstrated that S1PR1 and S1PR3 are responsible for S1P-induced migration of human BMSCs. In contrast, S1PR2 mediates the inhibition of migration. Additionally, we explored the downstream signaling pathway of the S1P/S1PRs axis and found that activation of S1PR1 or S1PR3 increased migration of human BMSCs through a Gi/extracellular regulated protein kinases 1/2- (ERK1/2-) dependent pathway, whereas activation of S1PR2 decreased migration through the Rho/Rho-associated protein kinase (ROCK) pathway. In conclusion, we reveal that the S1P/S1PRs signaling axis regulates the migration of human BMSCs via a dual-directional mechanism. Thus, selective modulation of S1PR's activity on human BMSCs may provide an effective approach to immunotherapy or tissue regeneration.

2010 - Demographic Research
Model migration schedules incorporating student migration peaks

This paper proposes an extension of the standard parameterised model migration schedule to account for highly age-concentrated student migration. Many age profiles of regional migration are characterised by sudden ‘spiked’ increases in migration intensities in the late teenage years, which are related to leaving school, and, in particular, to entry into higher education. The standard model schedule does not appear to be effective in describing the pattern at these ages. This paper therefore proposes an extension of the standard model through the addition of a student curve. The paper also describes a relatively simple Microsoft Excel-based fitting procedure. By way of illustration, both student peak and standard model schedules are fitted to the age patterns of internal migration for two Australian regions that experience substantial student migration. The student peak schedule is shown to provide an improved model of these migration age profiles. Illustrative population projections are presented to demonstrate the differences that result when model migration schedules with and without student peaks are used.

2009
Violence and Social Orders: The Conceptual Framework

Introduction The task of the social sciences is to explain the performance characteristics of societies through time, including the radical gap in human well-being between rich countries and poor as well as the contrasting forms of political organization, beliefs, and social structure that produce these variations in performance. Recorded human history began with the first social revolution – the Neolithic, agricultural, urban, or first economic revolution – and the appearance of the first large permanent groups of individuals between five thousand and ten thousand years ago. The second social revolution – the industrial, modern, or second economic revolution – began two hundred years ago and continues today. Changes in the organization of groups played a central role in this revolution as well. As Coleman describes it, “It is the corporate actors, the organizations that draw their power from persons and employ that power to corporate ends, that are the primary actors in the social structure of modern society” (1974, p. 49). The two social revolutions resulted in profound changes in the way societies were organized. The central task of this book is to articulate the underlying logic of the two new patterns of social organization, what we call social orders , and to explain how societies make the transition from one social order to the other. In order to understand why emergent features of modern developed societies, such as economic development and democracy, are so closely linked in the second social revolution, we are interested in the basic forces underlying patterns of the social order.

1998 - AIDS
Monocyte‐derived dendritic cells and monocytes migrate to HIV‐Tat RGD and basic peptides

Objective and design:Extracellular Tat released from HIV-1-infected cells is a mitogenic and motogenic factor for endothelial and Kaposi's sarcoma (KS)-derived cells and is angiogenic in vivo. Here we show for the first time that Tat induces migration of human dendritic cells in a concentration-dependent manner and that the Arg-Gly-Asp (RGD) and basic Tat peptides contribute to dendritic and monocyte cell migration. In vivo, Tat stimulates invasion of macrophages into a matrigel sponge. Methods:Monocyte and dendritic cell chemotaxis was assessed using the Boyden chamber assay. Results:Tat induced migration of monocyte-derived dendritic cells at the same levels as the N-formyl-Met-Leu-Phe peptide, and of monocytes at levels comparable to RANTES. Peptide mapping of the chemotactic activity of Tat showed that the RGD domain, which has been shown to support integrin-mediated cell migration, and the basic domain which binds and activates the tyrosine kinase receptor KDR on endothelial cells, both had activity. Antibody-blocking experiments indicate that responses to the RGD domain was inhibited by β1 and αvβ3 integrin blocking antibodies. Combination of the Tat RGD and basic peptides did not show additive effects; however, Tat co-operated with macrophage-chemotactic protein or RANTES in inducing monocyte migration. Conclusions:Our results show that Tat can act as a chemoattractant for dendritic cells, and that both the RGD and basic domains are involved in this response. These same domains attract monocytes. The αvβ3 and β1 integrins are equally involved in Tat-induced monocyte migration, while the αvβ3 integrin largely mediates the dendritic cell response to Tat.

2010 - Construction and Building Materials
On the time dependency of the chloride migration coefficient in concrete

Abstract From studies of the chloride penetration behaviour in laboratory tests and real structures, a clear time dependency of the chloride diffusion coefficient is observed. In order to get insight in this complicated problem, laboratory tests were performed with the non-steady state migration test, described in NT BUILD 492, up to 5 years concrete age. The influence of the type and amount of cement and filler and the amount of water on the migration coefficient and the so-called age factor of 16 self-compacting concrete mixes (SCC) and four traditional vibrated concrete mixes (TC) were investigated. The capillary porosity was introduced as parameter to describe the influence of the concrete composition. An increasing capillary porosity leads to an increased non-steady state migration coefficient and a decreasing age factor.

2009
South–South Migration and Human Development: Reflections on African Experiences

This paper looks at the relationship between migration between developing countries – or countries of the global ‘South’ – and processes of human development. The paper offers a critical analysis of the concept of South-South migration and draws attention to four fundamental problems. The paper then gives a broad overview of the changing patterns of migration in developing regions, with a particular focus on mobility within the African continent. It outlines some of the economic, social and political drivers of migration within poor regions, noting that these are also drivers of migration in the rest of the world. It also highlights the role of the state in influencing people’s movements and the outcomes of migration. The paper highlights the distinctive contribution that migration within developing regions makes to human development in terms of income, human capital and broader processes of social and political change. The paper concludes that the analysis of migration in poorer regions of the world and its relationship with human development requires much more data than is currently available.

1998 - Journal of Avian Biology
The timing of migration within the context of an annual routine

We illustrate how a general technique for finding optimal cyclic routines can be applied to annual routines of migration. We present a schematic model in which there are two locations that differ in terms of food availability. We demonstrate how the model can be used to investigate the factors that determine the timing of migration. Reproductive values emerge from the model rather than being assumed. The form of the relationships between reproductive value and a bird's energy reserves and condition on the completion of the autumn migration is very different from that on the completion of the spring migration. The difference suggests that the timing of migration is more critical in spring than in autumn.

1997 - Journal of Biological Systems
Adaptive Dynamics in a 2-patch Environment: a Simple Model for Allopatric and Parapatric Speciation

Adaptation to an environment consisting of two patches (each with different optimal strategy) is investigated. The patches have independent density regulation ('soft selection'). If the patches are similar enough and migration between them is strong, then evolution ends up with a generalist ESS. If either the difference between the patches increases or migration weakens, then the generalist strategy represent a branching singularity: The initially monomorphic population first evolves towards the generalist strategy, there it undergoes branching, and finally two specialist strategies form an evolutionarily stable coalition. Further increasing the between-patch difference or decreasing migration causes the generalist to lose its convergence stability as well, and an initially monomorphic population evolves towards one of the specialists optimally adapted to one of the two patches. Bifurcation pattern of the singularities is presented as a function of patch difference and migration rate. Connection to speciation theory is discussed. The transition from the generalist ESS to the coexisting pair of specialist strategies is regarded as a clonal prototype of parapatric (if the between-patch difference increases) or allopatric (if the migration decreases) speciation. We conclude that the geographic and the competitive speciation modes are not distinct classes.

2012
Theories and typologies of migration: an overview and a primer

Whilst the literature on international migration expands at a seemingly exponential rate, significant statements about the theorisation of migration are much less common; probably they are hindered by the increasing diversification of types of migration. This paper first reviews the various types of migration, and emphasises the need for an interdisciplinary approach to the study and theorisation of migration. In the main part of the paper I provide a personalised overview of theories of international migration, divided into the following sections: push-pull theory and the neoclassical approach; migration and development transitions; historical-structural and political economy models; the role of systems and networks; the ‘new economics’ of migration; and finally approaches based on the ‘transnational turn’ in migration studies. In the conclusion I point up some future challenges to theorising migration: the need to embed the study of migration within global processes of social, economic and political transformation and within the biographies of migrants’ lifecourses; the importance of also explaining why people do not migrate, and the notion of access to mobility as a differentiating factor of class and inequality; and the relevance of existential and emotional dimensions of migration. The paper is explicitly aimed at a student audience and is intended as a primer to understanding some of the complexities and challenges of theorising migration.

1994
The Work of Strangers: A Survey of International Labour Migration

The migration of workers across international boundaries has a major impact worldwide. This topical study provides an analysis of labour migration spanning the globe. The author brings labour migration - its volume, characteristic effects, the reactions it provokes and the policiies it requires. He addresses such hotly debated questions as defining national borders, assimilation versus cultural autonomy and exclusion of migrants. The book is organized into two parts. The first part paints the global picture, starting with the slave trade and indentured labour, and then examines why people move today, as well as the costs and benefits of migration. Topics such as naturalization, the role of religion, attracting entrepreneurs into a country and illegal migration are explored. Part two examines the recent experience of some 20 countries and several regions of the world - North Caribbean, sub-Saharan Africa, the Gulf States and Asia. The text is illustrated with numerous charts and statistical tables, including a comprehensive "global economic migration table".

2001 - Population and Development Review
The Age of Migration in China

Using data from the 1987 and 1995 China One Percent Population Sample Surveys, this article examines migration patterns during 1982-95, a period of sweeping social and economic changes in China. Several major patterns are evident: the increase in overall migration and especially in temporary migration, the increasing importance of inter-provincial migration, and the concentration of migrants in the coastal region. Over time, migrants of rural origin were more likely to choose cities as destinations than towns. The consequences and implications of the changes in migration patterns are explored. Copyright 2001 by The Population Council, Inc..

2005 - The Journal of Cell Biology
A Rac switch regulates random versus directionally persistent cell migration

Directional migration moves cells rapidly between points, whereas random migration allows cells to explore their local environments. We describe a Rac1 mechanism for determining whether cell patterns of migration are intrinsically random or directionally persistent. Rac activity promoted the formation of peripheral lamellae that mediated random migration. Decreasing Rac activity suppressed peripheral lamellae and switched the cell migration patterns of fibroblasts and epithelial cells from random to directionally persistent. In three-dimensional rather than traditional two-dimensional cell culture, cells had a lower level of Rac activity that was associated with rapid, directional migration. In contrast to the directed migration of chemotaxis, this intrinsic directional persistence of migration was not mediated by phosphatidylinositol 3′-kinase lipid signaling. Total Rac1 activity can therefore provide a regulatory switch between patterns of cell migration by a mechanism distinct from chemotaxis.

Social structure, household strategies, and the cumulative causation of migration.

D. Massey
|
D S Massey

Abstract:This review culls disparate elements from the theoretical and research literature on human migration to argue for the construction of a theory of migration that simultaneously incorporates multiple levels of analysis within a longitudinal perspective. A detailed review of interconnections among individual behavior, household strategies, community structures, and national political economies indicates that inter-level and inter-temporal dependencies are inherent to the migration process and give it a strong internal momentum. The dynamic interplay between network growth and individual migration labor, migration remittances, and local income distributions all create powerful feedback mechanisms that lead to the cumulative causation of migration. These mechanisms are reinforced and shaped by macrolevel relationships within the larger political economy.

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2019
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Inf. Syst. Res.
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Dual Citizenship Allowance and Migration Flow
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1999
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2014
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1997
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