Physical interactions of static magnetic fields with living tissues.
Abstract:Clinical magnetic resonance imaging (MRI) was introduced in the early 1980s and has become a widely accepted and heavily utilized medical technology. This technique requires that the patients being studied be exposed to an intense magnetic field of a strength not previously encountered on a wide scale by humans. Nonetheless, the technique has proved to be very safe and the vast majority of the scans have been performed without any evidence of injury to the patient. In this article the history of proposed interactions of magnetic fields with human tissues is briefly reviewed and the predictions of electromagnetic theory on the nature and strength of these interactions are described. The physical basis of the relative weakness of these interactions is attributed to the very low magnetic susceptibility of human tissues and the lack of any substantial amount of ferromagnetic material normally occurring in these tissues. The presence of ferromagnetic foreign bodies within patients, or in the vicinity of the scanner, represents a very great hazard that must be scrupulously avoided. As technology and experience advance, ever stronger magnetic field strengths are being brought into service to improve the capabilities of this imaging technology and the benefits to patients. It is imperative that vigilance be maintained as these higher field strengths are introduced into clinical practice to assure that the high degree of patient safety that has been associated with MRI is maintained.
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[1] Makio Murayama,et al. Molecular Mechanism of Red Cell "Sickling" , 1966, Science.
[2] S. Ogawa,et al. Magnetic resonance imaging of blood vessels at high fields: In vivo and in vitro measurements and image simulation , 1990, Magnetic resonance in medicine.
[3] I. M. Plavnieks,et al. Bibliography of the biological effects of magnetic fields. , 1962, Federation proceedings.
[4] J. Schenck. Safety of Strong, Static Magnetic Fields , 2000, Journal of magnetic resonance imaging : JMRI.
[5] D. Worcester,et al. Structural origins of diamagnetic anisotropy in proteins. , 1978, Proceedings of the National Academy of Sciences of the United States of America.
[6] J. F. Becker,et al. Magnetic field induced orientation of photosynthetic systems. , 1972, Biochimica et biophysica acta.
[7] S. Ogawa,et al. Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields , 1990, Magnetic resonance in medicine.
[8] M F Barnothy,et al. Biological effects of magnetic fields. , 1974, Progress in biometeorology. Division A: Progress in human biometeorology.
[9] István Nagypál,et al. A family of magnetic field dependent chemical waves , 1994 .
[10] R. Tournier,et al. Levitation of organic materials , 1991, Nature.
[11] Michael V Berry,et al. Of flying frogs and levitrons , 1997 .
[12] Paul C. Lauterbur,et al. Image formation by induced local interactions , 1973 .
[13] P A Valberg,et al. Magnetic particle motions within living cells. Measurement of cytoplasmic viscosity and motile activity. , 1987, Biophysical journal.
[14] David T. Vaughn,et al. Biologic and Clinical Effects of Low-Frequency Magnetic and Electric Fields , 1975 .
[15] C. D. Coryell,et al. The Magnetic Susceptibility of the Iron in Ferrohemoglobin , 1938 .
[16] Martin N. Wilson,et al. Superconducting Magnets , 1984 .
[17] J. G. Llaurado,et al. Biological and clinical effects of low-frequency magnetic and electric fields , 1974 .
[18] D. Cohen,et al. Ferromagnetic Contamination in the Lungs and Other Organs of the Human Body , 1973, Science.
[19] Budinger Tf. MR safety: past, present, and future from a historical perspective. , 1998 .
[20] J. Barnothy,et al. Biological Effect of a Magnetic Field and the Radiation Syndrome , 1958, Nature.
[21] István Nagypál,et al. Effect of magnetic fields on a propagating reaction front , 1990, Nature.
[22] A. Kangarlu,et al. Cognitive, cardiac, and physiological safety studies in ultra high field magnetic resonance imaging. , 1999, Magnetic resonance imaging.
[23] C A Gooding,et al. Preservation of sickle cell blood-flow patterns during MR imaging: an in vivo study. , 1988, AJR. American journal of roentgenology.
[24] J. Kirschvink,et al. Magnetite biomineralization in the human brain. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[25] J. Israelachvili. Intermolecular and surface forces , 1985 .
[26] Carolyn A. Richardson,et al. Low gravity on earth by magnetic levitation of biological material. , 2002 .
[27] T. Tenforde,et al. Theoretical analysis of magnetic field interactions with aortic blood flow. , 1996, Bioelectromagnetics.
[28] G. Maret,et al. Fibrinogen and fibrin structure and fibrin formation measured by using magnetic orientation. , 1983, Proceedings of the National Academy of Sciences of the United States of America.
[29] C L Dumoulin,et al. Human exposure to 4.0-Tesla magnetic fields in a whole-body scanner. , 1992, Medical physics.
[30] Alexander R. Margulis,et al. Biomedical magnetic resonance , 1986 .
[31] E Kanal,et al. MR imaging of patients with intracranial aneurysm clips. , 1993, Radiology.
[32] P. Mansfield,et al. NMR 'diffraction' in solids? , 1973 .
[33] Thomas F. Budinger,et al. Health Effects of In Vivo Nuclear Magnetic Resonance , 1985, IEEE Engineering in Medicine and Biology Magazine.
[34] J. Schenck,et al. Health and Physiological Effects of Human Exposure to Whole‐Body Four‐Tesla Magnetic Fields during MRI , 1992, Annals of the New York Academy of Sciences.
[35] D. E. Beischer,et al. HUMAN TOLERANCE TO MAGNETIC FIELDS , 1962 .
[36] T. Brandt. Vertigo: Its Multisensory Syndromes , 1991, Clinical Medicine and the Nervous System.
[37] G. Radda,et al. Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. , 1982, Biochimica et biophysica acta.
[38] J. Keltner,et al. Magnetohydrodynamics of blood flow , 1990, Magnetic resonance in medicine.
[39] J. Denegre,et al. Cleavage planes in frog eggs are altered by strong magnetic fields. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[40] Shoogo Ueno,et al. Parting of water by magnetic fields , 1994 .
[41] D. Melville,et al. High gradient magnetic separation of red cells from whole blood , 1975 .
[42] MAKIO MURAYAMA,et al. Orientation of Sickled Erythrocytes in a Magnetic Field , 1965, Nature.
[43] Thomas S Tenforde,et al. Magnetically induced electric fields and currents in the circulatory system. , 2005, Progress in biophysics and molecular biology.
[44] William Thomson,et al. Reprint of Papers on Electrostatics and Magnetism , 2008, Nature.
[45] V. Fuchs,et al. Physicians' views of the relative importance of thirty medical innovations. , 2001, Health affairs.
[46] R. Banerjee,et al. Magnetic susceptibility measurements of deoxygenated hemoglobins and isolated chains. , 1975, Biochimica et biophysica acta.
[47] Q. Pankhurst,et al. Preliminary evaluation of nanoscale biogenic magnetite in Alzheimer's disease brain tissue , 2003, Proceedings of the Royal Society of London. Series B: Biological Sciences.
[48] P A Valberg,et al. Magnetic particle motions within living cells. Physical theory and techniques. , 1987, Biophysical journal.
[49] C A Gooding,et al. AUR memorial Award. Induced alignment of flowing sickle erythrocytes in a magnetic field. A preliminary report. , 1985, Investigative radiology.
[50] R. Klucznik,et al. Placement of a ferromagnetic intracerebral aneurysm clip in a magnetic field with a fatal outcome. , 1993, Radiology.
[51] J. Marx,et al. ORIENTATION OF FIBRIN IN STRONG MAGNETIC FIELDS , 1983, Annals of the New York Academy of Sciences.
[52] J. Schenck. The role of magnetic susceptibility in magnetic resonance imaging: MRI magnetic compatibility of the first and second kinds. , 1996, Medical physics.
[53] Beischer De,et al. INFLUENCE OF STRONG MAGNETIC FIELDS ON THE ELECTROCARDIOGRAM OF SQUIRREL MONKEYS (SAIMIRI SCIUREUS). PROJECT MR005.13-9010, SUBTASK 1, REP NO. 8. , 1964 .
[54] S E Robinson,et al. Non-invasive magnetopneumographic estimation of lung dust loads and distribution in bituminous coal workers. , 1980, Journal of occupational medicine. : official publication of the Industrial Medical Association.
[55] Adam Crabtree,et al. From Mesmer to Freud: Magnetic Sleep and the Roots of Psychological Healing , 1993 .
[56] Alvaro Pascual-Leone,et al. Handbook of transcranial magnetic stimulation , 2002 .
[57] R. Macklis,et al. Magnetic Healing, Quackery, and the Debate about the Health Effects of Electromagnetic Fields , 1993, Annals of Internal Medicine.
[58] Jon Dobson,et al. Magnetic Iron Compounds in Neurological Disorders , 2004, Annals of the New York Academy of Sciences.
[59] J. Howard,et al. Mechanics of Motor Proteins and the Cytoskeleton , 2001 .
[60] J. Torbet,et al. Oriented fibrin gels formed by polymerization in strong magnetic fields , 1981, Nature.
[61] G. Maret,et al. The susceptibility of pure tubulin to high magnetic fields: a magnetic birefringence and x-ray fiber diffraction study. , 1998, Biophysical journal.
[62] T F Budinger,et al. Cardiovascular alterations in Macaca monkeys exposed to stationary magnetic fields: experimental observations and theoretical analysis. , 1983, Bioelectromagnetics.
[63] Iku Nemoto,et al. Ferrimagnetic Particles in the Lung Part II: The Relaxation; Process , 1984, IEEE Transactions on Biomedical Engineering.
[64] P. Lauterbur,et al. Image Formation by Induced Local Interactions: Examples Employing Nuclear Magnetic Resonance , 1973, Nature.
[65] S Roath,et al. Differential Blood Cell Separation using a High Gradient Magnetic Field , 1978, British journal of haematology.
[66] Frank G. Shellock,et al. Magnetic Resonance: Bioeffects, Safety and Patient Management , 1994 .
[67] P. Lorrain,et al. Electromagnetic fields and waves , 1970 .
[68] Y Kinouchi,et al. Effects of static magnetic fields on diffusion in solutions. , 1988, Bioelectromagnetics.
[69] T F Budinger,et al. Nuclear Magnetic Resonance (NMR) In Vivo Studies: Known Thresholds for Health Effects , 1981, Journal of computer assisted tomography.
[70] Felix T. Hong,et al. Photoelectric and Magneto-Orientation Effects in Pigmented Biological Membranes , 1977 .
[71] Ravi S. Menon,et al. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. , 1993, Biophysical journal.
[72] A. Geim,et al. Magnet levitation at your fingertips , 1999, Nature.
[73] M MURAYAMA,et al. MOLECULAR ORIENTATION IN HORSE HEMOGLOBIN CRYSTALS AND SICKLED ERYTHROCYTES. , 1965, Biochimica et biophysica acta.
[74] A. Kolin,et al. Improved Apparatus and Technique for Electromagnetic Determination of Blood Flow , 1952 .
[75] M. Mourino,et al. From Thales to Lauterbur, or from the lodestone to MR imaging: magnetism and medicine. , 1991, Radiology.
[76] R A Brooks,et al. Relaxometry and magnetometry of ferritin , 1998, Magnetic resonance in medicine.
[77] Maurice M. Tinterow,et al. Foundations of Hypnosis, from Mesmer to Freud, , 1970 .
[78] Léon Chertok,et al. The therapeutic revolution, from Mesmer to Freud , 1979 .
[79] H Kanai,et al. Transcutaneous blood flow measurement by electromagnetic induction. , 1974, IEEE transactions on bio-medical engineering.
[80] J. V. Vleck,et al. The theory of electric and magnetic susceptibilities , 1934, The Mathematical Gazette.
[81] F T Hong,et al. Magnetic anisotropy and the orientation of retinal rods in a homogeneous magnetic field. , 1971, Proceedings of the National Academy of Sciences of the United States of America.
[82] J. Denegre,et al. Stable magnetic field gradient levitation of Xenopus laevis: toward low-gravity simulation. , 1996, Biophysical journal.
[83] J. Barnothy,et al. Influence of a Magnetic Field upon the Leucocytes of the Mouse , 1956, Nature.
[84] Nino Boccara,et al. Biophysical Effects of Steady Magnetic Fields , 1986 .
[85] J E EISELEIN,et al. Biological effects of magnetic fields--negative results. , 1961, Aerospace medicine.
[86] Caterina Schweidenback,et al. Processes that occur before second cleavage determine third cleavage orientation in Xenopus. , 2002, Experimental cell research.
[87] T. Togawa,et al. Observation of blood flow E.M.F. in externally applied strong magnetic field by surface electrodes , 1967, Medical and biological engineering.
[88] B. Persson,et al. Biological effects and safety aspects of nuclear magnetic resonance imaging and spectroscopy , 1992 .
[89] F B Johnson,et al. Identification and significance of magnetite in human tissues. , 1986, Archives of pathology & laboratory medicine.
[90] Iku Nemoto,et al. Ferrimagnetic Particles in the Lung Part 1: The Magnetizing Process , 1984, IEEE Transactions on Biomedical Engineering.
[91] R. D. Saunders,et al. Safety aspects of NMR clinical imaging. , 1984, British medical bulletin.
[92] A. Sances,et al. Steady magnetic fields in noninvasive electromagnetic flowmetry , 1980, Proceedings of the IEEE.
[93] W. Edelstein,et al. Spin warp NMR imaging and applications to human whole-body imaging. , 1980, Physics in medicine and biology.
[94] J. Philo,et al. Diamagnetism of human apo-, oxy-, and (carbonmonoxy)hemoglobin. , 1984, Biochemistry.
[95] Shoogo Ueno,et al. Rise and fall of surface level of water solutions under high magnetic field , 1995 .
[96] R. L. Park,et al. Voodoo Science: The Road from Foolishness to Fraud , 2000 .
[97] Alayar Kangarlu,et al. Effect of static magnetic field exposure of up to 8 Tesla on sequential human vital sign measurements , 2003, Journal of magnetic resonance imaging : JMRI.
[98] Thomas F. Budinger,et al. Thresholds for Physiological Effects Due to RF and Magnetic Fields Used in NMR Imaging , 1979, IEEE Transactions on Nuclear Science.
[99] T. Tenforde,et al. Alterations in the rat electrocardiogram induced by stationary magnetic fields. , 1981, Bioelectromagnetics.
[100] E. M. Lifshitz,et al. Electrodynamics of continuous media , 1961 .
[101] J M Freyssinet,et al. Fibrinogen and fibrin in strong magnetic fields. Complementary results and discussion. , 1984, Biochimie.
[102] J. Dobson,et al. Nanoscale biogenic iron oxides and neurodegenerative disease , 2001, FEBS letters.