InterPro in 2017—beyond protein family and domain annotations

InterPro (http://www.ebi.ac.uk/interpro/) is a freely available database used to classify protein sequences into families and to predict the presence of important domains and sites. InterProScan is the underlying software that allows both protein and nucleic acid sequences to be searched against InterPro's predictive models, which are provided by its member databases. Here, we report recent developments with InterPro and its associated software, including the addition of two new databases (SFLD and CDD), and the functionality to include residue-level annotation and prediction of intrinsic disorder. These developments enrich the annotations provided by InterPro, increase the overall number of residues annotated and allow more specific functional inferences.

Silvio C. E. Tosatto | Neil D. Rawlings | Huaiyu Mi | Robert D. Finn | Marco Necci | Narmada Thanki | Damiano Piovesan | Cathy H. Wu | Terri K. Attwood | Rodrigo Lopez | Alan Bridge | Ioannis Xenarios | Shennan Lu | Aron Marchler-Bauer | Patricia C. Babbitt | Ian Sillitoe | Christine A. Orengo | Zsuzsanna Dosztányi | Gemma L. Holliday | Darren A. Natale | Hongzhan Huang | Ivica Letunic | Alex Bateman | Christian J. A. Sigrist | Alex L. Mitchell | Granger G. Sutton | Jaina Mistry | Paul D. Thomas | Xiaosong Huang | Julian Gough | Nicole Redaschi | Simon C. Potter | Hsin-Yu Chang | Sara El-Gebali | Lai-Su L. Yeh | Catherine Rivoire | Silvano Squizzato | Youngmi Park | David Haft | Peer Bork | Matthew Fraser | Gift Nuka | Sebastien Pesseat | Lorna Richardson | Amaia Sangrador-Vegas | Ben Smithers | Siew-Yit Yong | A. Marchler-Bauer | C. Orengo | P. Bork | G. Sutton | S. Potter | D. Natale | J. Gough | R. Finn | Jaina Mistry | A. Bateman | Damiano Piovesan | P. Babbitt | P. Thomas | I. Xenarios | T. Attwood | I. Letunic | R. Lopez | C. Sigrist | N. Thanki | H. Mi | I. Sillitoe | A. Bridge | N. Rawlings | Xiaosong Huang | Z. Dosztányi | Hongzhan Huang | N. Redaschi | L. Yeh | A. Mitchell | Lorna J. Richardson | A. Sangrador-Vegas | C. Rivoire | S. Tosatto | S. Squizzato | B. Smithers | Y. M. Park | M. Necci | Hsin-Yu Chang | Sara El-Gebali | Youngmi Park | M. Fraser | Gift Nuka | I. Letunić | Shennan Lu | Sebastien Pesseat | Siew-Yit Yong | David Haft | Young Mi Park | Nicole Redaschi | Ivica Letunic | Simon C. Potter | Ben Smithers | Aron Marchler-Bauer

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