Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
暂无分享,去创建一个
Qingsong Liu | K. Machida | Weiming Yuan | Liling Tang | Min Yu | O. Akbari | V. Punj | C. Liang | Hongrui Guo | G. In | H. Maazi | Ying Song | D. Peng | Christine Quach | Yongfei Yang | Shihui Zhao | A. Hagiya | Gyu-beom Jang | Shun Li | Nathaniel A. Sands | David H. Peng
[1] Maria Matarese,et al. mTOR-dependent phosphorylation controls TFEB nuclear export , 2018, Nature Communications.
[2] Xiaoyu Liang,et al. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype , 2018, Nature Communications.
[3] Liang Cheng,et al. Molecular testing for BRAF mutations to inform melanoma treatment decisions: a move toward precision medicine , 2017, Modern Pathology.
[4] G. Mills,et al. A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. , 2017, Cancer discovery.
[5] P. Mallick,et al. JUN-Mediated Downregulation of EGFR Signaling Is Associated with Resistance to Gefitinib in EGFR-mutant NSCLC Cell Lines , 2017, Molecular Cancer Therapeutics.
[6] B. Razani,et al. Transcriptional factor EB regulates macrophage polarization in the tumor microenvironment , 2017, Oncoimmunology.
[7] J. Neilson,et al. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases , 2017, Nature Communications.
[8] M. Weller,et al. Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells , 2016, Oncotarget.
[9] Chonglin Yang,et al. Protein kinase C controls lysosome biogenesis independently of mTORC1 , 2016, Nature Cell Biology.
[10] V. Promponas,et al. iLIR database: A web resource for LIR motif-containing proteins in eukaryotes , 2016, Autophagy.
[11] H. Brenner,et al. Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. , 2016, Gastroenterology.
[12] E. Sokol,et al. AMPK promotes tolerance to Ras pathway inhibition by activating autophagy , 2016, Oncogene.
[13] Arati Sharma,et al. Current State of Animal (Mouse) Modeling in Melanoma Research , 2015, Cancer growth and metastasis.
[14] K. Ross,et al. Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism , 2015, Nature.
[15] E. White,et al. Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma. , 2015, Cancer discovery.
[16] A. Ballabio,et al. Lysosomal calcium signaling regulates autophagy via calcineurin and TFEB , 2015, Nature Cell Biology.
[17] A. Rust,et al. BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model , 2015, Proceedings of the National Academy of Sciences.
[18] Q. Zhong. Faculty Opinions recommendation of Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma. , 2015 .
[19] W. Huber,et al. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.
[20] A. Ballabio,et al. Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae , 2014, Arteriosclerosis, thrombosis, and vascular biology.
[21] Frank McCormick,et al. Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond , 2014, Nature Reviews Cancer.
[22] A. Alavi,et al. Combined MTOR and autophagy inhibition , 2014, Autophagy.
[23] R. Bernards,et al. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma , 2014, Nature.
[24] M. Herlyn,et al. Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma. , 2014, The Journal of clinical investigation.
[25] H. Simon,et al. Autophagy suppresses melanoma tumorigenesis by inducing senescence , 2014, Autophagy.
[26] Samy Lamouille,et al. Molecular mechanisms of epithelial–mesenchymal transition , 2014, Nature Reviews Molecular Cell Biology.
[27] J. Martina,et al. The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris , 2014, Science Signaling.
[28] R. Bernards,et al. TGF-β: An emerging player in drug resistance , 2013, Cell cycle.
[29] S. Knapp,et al. Copper is required for oncogenic BRAF signaling and tumorigenesis , 2013, Nature.
[30] A. Kamat,et al. ZKSCAN3 is a master transcriptional repressor of autophagy. , 2013, Molecular cell.
[31] Matthew Meyerson,et al. A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1 , 2013, Science.
[32] J. Martina,et al. Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes , 2013, The Journal of cell biology.
[33] K. Guan,et al. Amino acid signalling upstream of mTOR , 2013, Nature Reviews Molecular Cell Biology.
[34] D. Rubinsztein,et al. Autophagy modulation as a potential therapeutic target for diverse diseases , 2012, Nature Reviews Drug Discovery.
[35] T. Walther,et al. The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis , 2012, Science Signaling.
[36] P. Chaudhary,et al. A Computational Profiling of Changes in Gene Expression and Transcription Factors Induced by vFLIP K13 in Primary Effusion Lymphoma , 2012, PloS one.
[37] Yong Chen,et al. MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB , 2012, Autophagy.
[38] T. Gilmer,et al. Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated by NRAS or MEK Mutations , 2012, Molecular Cancer Therapeutics.
[39] A. Ballabio,et al. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB , 2012, The EMBO journal.
[40] Meenhard Herlyn,et al. Resistance to BRAF inhibitors: unraveling mechanisms and future treatment options. , 2011, Cancer research.
[41] Andrea Ballabio,et al. TFEB Links Autophagy to Lysosomal Biogenesis , 2011, Science.
[42] G. Mann,et al. Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[43] S. Nelson,et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation , 2010, Nature.
[44] K. Flaherty,et al. Inhibition of mutated, activated BRAF in metastatic melanoma. , 2010, The New England journal of medicine.
[45] K. Hoek,et al. GLI2-mediated melanoma invasion and metastasis. , 2010, Journal of the National Cancer Institute.
[46] B. Taylor,et al. The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner , 2010, Proceedings of the National Academy of Sciences.
[47] W. Huber,et al. which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets , 2011 .
[48] J. Thiery. [Epithelial-mesenchymal transitions in cancer onset and progression]. , 2009, Bulletin de l'Academie nationale de medecine.
[49] S. Pattingre,et al. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. , 2008, Molecular cell.
[50] Kam Y. J. Zhang,et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity , 2008, Proceedings of the National Academy of Sciences.
[51] Robin Mathew,et al. Role of autophagy in cancer , 2007, Nature Reviews Cancer.
[52] E. White,et al. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. , 2007, Genes & development.
[53] E. White,et al. Autophagy suppresses tumor progression by limiting chromosomal instability. , 2007, Genes & development.
[54] J. Urano,et al. Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells , 2007, Proceedings of the National Academy of Sciences.
[55] E. White,et al. Role of Autophagy in Cancer: Management of Metabolic Stress , 2007, Autophagy.
[56] Kevin Bray,et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. , 2006, Cancer cell.
[57] T. Kinoshita,et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. , 2005, Biochemical and biophysical research communications.
[58] M. Daly,et al. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.
[59] B. Doble,et al. GSK-3: tricks of the trade for a multi-tasking kinase , 2003, Journal of Cell Science.
[60] Takeshi Noda,et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.
[61] M. Skobe,et al. Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas. , 1999, The American journal of pathology.
[62] E. Rogakou,et al. DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139* , 1998, The Journal of Biological Chemistry.
[63] P. Cohen,et al. Mechanism of activation of protein kinase B by insulin and IGF‐1. , 1996, The EMBO journal.
[64] P. Seglen,et al. 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[65] D. Medina,et al. TFEB and the CLEAR network. , 2015, Methods in cell biology.
[66] Dennis C. Friedrich,et al. MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition. , 2014, Cancer discovery.
[67] J. Haveman,et al. Clonogenic assay of cells in vitro , 2006, Nature Protocols.