Left parietal TMS disturbs priming between symbolic and non-symbolic number representations

An amodal number representation activated by all types of numerical input, irrespective of the input notation, has often been proposed to be located in the left or right intraparietal sulcus (IPS). Two cross-notational priming experiments were carried out to test the existence of a notation-independent magnitude representation in the left or right parietal lobes. In Experiment 1, stimuli were Arabic digits and number words. Results revealed no significant effect of repetitive transcranial magnetic stimulation (rTMS) over left or right IPS during prime presentation. In contrast, in Experiment 2, digits and dot patterns were intermixed and here the priming distance effect (PDE) was reduced in the right TMS condition and absent for stimulation over left IPS. These findings suggest: (1) that TMS over left but not right IPS disrupts processes that are crucial for priming when symbolic and non-symbolic stimuli are intermixed, and (2) that disruption of the left IPS on its own is not sufficient to disrupt cross-notational priming when purely symbolic number notations are used. Our results point towards a crucial role of the left hemisphere for the mapping between small symbolic and non-symbolic numerosities.

[1]  R. Cohen Kadosh,et al.  Numerical representation in the parietal lobes: abstract or not abstract? , 2009, The Behavioral and brain sciences.

[2]  Gustavo Deco,et al.  Human Neuroscience Original Research Article Cortical Microcircuit Dynamics Mediating Binocular Rivalry: the Role of Adaptation in Inhibition , 2022 .

[3]  Elizabeth M. Brannon,et al.  The Neural Development of an Abstract Concept of Number , 2009, Journal of Cognitive Neuroscience.

[4]  Daniel Ansari,et al.  Challenging the reliability and validity of cognitive measures: the case of the numerical distance effect. , 2010, Acta psychologica.

[5]  Avishai Henik,et al.  Notation-Dependent and -Independent Representations of Numbers in the Parietal Lobes , 2007, Neuron.

[6]  M. McCloskey.  Cognitive mechanisms in numerical processing: Evidence from acquired dyscalculia , 1992, Cognition.

[7]  Brian Butterworth,et al.  Core information processing deficits in developmental dyscalculia and low numeracy. , 2008, Developmental science.

[8]  Á. Pascual-Leone,et al.  Transcranial Magnetic Stimulation , 2014, Neuromethods.

[9]  A. Ischebeck,et al.  An fMRI study of the numerical Stroop task in individuals with and without minimal cognitive impairment , 2008, Cortex.

[10]  S. Dehaene.  Varieties of numerical abilities , 1992, Cognition.

[11]  M. Noël,et al.  Basic numerical skills in children with mathematics learning disabilities: A comparison of symbolic vs non-symbolic number magnitude processing , 2007, Cognition.

[12]  Roi Cohen Kadosh,et al.  Numerical representation : Abstract or nonabstract ? , 2008 .

[13]  Roi Cohen Kadosh,et al.  Numerical representation: Abstract or nonabstract? , 2008 .

[14]  Bert Reynvoet,et al.  The neural origin of the priming distance effect: Distance‐dependent recovery of parietal activation using symbolic magnitudes , 2009, Human brain mapping.

[15]  S. Dehaene,et al.  The mental representation of parity and number magnitude. , 1993 .

[16]  Karin Landerl,et al.  Typical and atypical development of basic numerical skills in elementary school. , 2009, Journal of experimental child psychology.

[17]  Alan Cowey,et al.  Transcranial magnetic stimulation and cognitive neuroscience , 2000, Nature Reviews Neuroscience.

[18]  C. Gilmore,et al.  Children's mapping between symbolic and nonsymbolic representations of number. , 2009, Journal of experimental child psychology.

[19]  S. Dehaene,et al.  A Magnitude Code Common to Numerosities and Number Symbols in Human Intraparietal Cortex , 2007, Neuron.

[20]  Stanislas Dehaene,et al.  The Organization of Brain Activations in Number Comparison: Event-Related Potentials and the Additive-Factors Method , 1996, Journal of Cognitive Neuroscience.

[21]  Daniel Ansari,et al.  Developmental Specialization in the Right Intraparietal Sulcus for the Abstract Representation of Numerical Magnitude , 2010, Journal of Cognitive Neuroscience.

[22]  Andreas Nieder,et al.  Semantic Associations between Signs and Numerical Categories in the Prefrontal Cortex , 2007, PLoS biology.

[23]  C. Frith,et al.  Differential Activation of Right Superior Parietal Cortex and Intraparietal Sulcus by Spatial and Nonspatial Attention , 1998, NeuroImage.

[24]  Michael Andres,et al.  Hemispheric lateralization of number comparison. , 2005, Brain research. Cognitive brain research.

[25]  S. Dehaene,et al.  The Number Sense: How the Mind Creates Mathematics. , 1998 .

[26]  Brian Butterworth,et al.  Evidence for Two Numerical Systems That Are Similar in Humans and Guppies , 2012, PloS one.

[27]  Stanislas Dehaene,et al.  Primed numbers : Exploring the modularity of numerical representations with masked and unmasked semantic priming , 1999 .

[28]  Bahador Bahrami,et al.  Human Neuroscience , 2022 .

[29]  Bert Reynvoet,et al.  The Magnitude Representation of Small and Large Symbolic Numbers in the Left and Right Hemisphere: An Event-related fMRI Study , 2010, Journal of Cognitive Neuroscience.

[30]  E. Wassermann.  Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. , 1998, Electroencephalography and clinical neurophysiology.

[31]  M. Brysbaert,et al.  Semantic priming in number naming , 2002, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[32]  Melissa E. Libertus,et al.  Electrophysiological evidence for notation independence in numerical processing , 2007, Behavioral and Brain Functions.

[33]  E. Spelke,et al.  Large number discrimination in 6-month-old infants , 2000, Cognition.

[34]  Bert De Smedt,et al.  Defective number module or impaired access? Numerical magnitude processing in first graders with mathematical difficulties. , 2011, Journal of experimental child psychology.

[35]  S. Dehaene,et al.  Abstract representations of numbers in the animal and human brain , 1998, Trends in Neurosciences.

[36]  E. Wassermann,et al.  A safety screening questionnaire for transcranial magnetic stimulation , 2001, Clinical Neurophysiology.

[37]  Emmy Defever,et al.  Association between basic numerical abilities and mathematics achievement. , 2012, The British journal of developmental psychology.

[38]  K. Grill-Spector,et al.  fMR-adaptation: a tool for studying the functional properties of human cortical neurons. , 2001, Acta psychologica.

[39]  P. Macizo,et al.  Cross-notational semantic priming between symbolic and nonsymbolic numerosity , 2008, Quarterly journal of experimental psychology.

[40]  Daniel Ansari,et al.  Mapping numerical magnitudes onto symbols: the numerical distance effect and individual differences in children's mathematics achievement. , 2009, Journal of experimental child psychology.

[41]  S. Dehaene,et al.  The priming method: imaging unconscious repetition priming reveals an abstract representation of number in the parietal lobes. , 2001, Cerebral cortex.

[42]  A. Nieder.  Prefrontal cortex and the evolution of symbolic reference , 2009, Current Opinion in Neurobiology.

[43]  M. Brysbaert,et al.  Are Arabic numerals processed as pictures in a Stroop interference task? , 2001, Psychological research.

[44]  Elizabeth M. Brannon,et al.  Beyond the number domain , 2009, Trends in Cognitive Sciences.

[45]  D. Ansari.  Effects of development and enculturation on number representation in the brain , 2008, Nature Reviews Neuroscience.

[46]  D. LeBihan,et al.  Modulation of Parietal Activation by Semantic Distance in a Number Comparison Task , 2001, NeuroImage.

[47]  Daniel Ansari,et al.  Evidence against a strong association between numerical symbols and the quantities they represent , 2012, CogSci.