Targeting Mcl-1 for multiple myeloma (MM) therapy: drug-induced generation of Mcl-1 fragment Mcl-1(128-350) triggers MM cell death via c-Jun upregulation.

[1]  Stefan P. Glaser,et al.  Mcl-1 is essential for the survival of plasma cells , 2013, Nature Immunology.

[2]  J. Opferman,et al.  Delving deeper: MCL-1's contributions to normal and cancer biology. , 2013, Trends in cell biology.

[3]  J. Westermarck,et al.  Nucleolar AATF regulates c-Jun–mediated apoptosis , 2012, Molecular biology of the cell.

[4]  Daniel P. Stewart,et al.  Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration , 2012, Nature Cell Biology.

[5]  Andrew L. Kung,et al.  Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency. , 2012, Cancer cell.

[6]  Yuefeng Yang,et al.  Overexpression of microRNA-29b induces apoptosis of multiple myeloma cells through down regulating Mcl-1. , 2011, Biochemical and biophysical research communications.

[7]  M. Amiot,et al.  Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction. , 2011, Biochemical and biophysical research communications.

[8]  P. Fisher,et al.  Targeting Mcl-1 for the therapy of cancer , 2011, Expert opinion on investigational drugs.

[9]  Adam R. Johnson,et al.  Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 , 2011, Nature.

[10]  Trevor J Pugh,et al.  Initial genome sequencing and analysis of multiple myeloma , 2011, Nature.

[11]  I. Pollack,et al.  Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF-κB Signaling Pathway , 2011, Molecular Cancer Therapeutics.

[12]  S. Edwards,et al.  Mcl‐1; the molecular regulation of protein function , 2010, FEBS letters.

[13]  E. Shaulian.  AP-1--The Jun proteins: Oncogenes or tumor suppressors in disguise? , 2010, Cellular signalling.

[14]  Oliver Kohlbacher,et al.  YLoc—an interpretable web server for predicting subcellular localization , 2010, Nucleic Acids Res..

[15]  J. Gribben,et al.  GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death. , 2010, Blood.

[16]  Michael R. Green,et al.  A genome-wide RNA interference screen reveals an essential CREB3L2/ATF5/MCL1 survival pathway in malignant glioma with therapeutic implications , 2010, Nature Medicine.

[17]  M. Amiot,et al.  Mcl‐1128–350 fragment induces apoptosis through direct interaction with Bax , 2010, FEBS letters.

[18]  Derek Y. Chiang,et al.  The landscape of somatic copy-number alteration across human cancers , 2010, Nature.

[19]  F. Bazan,et al.  Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival , 2010, Nature.

[20]  B. Meister,et al.  The Anti-apoptotic Protein BCL2L1/Bcl-xL Is Neutralized by Pro-apoptotic PMAIP1/Noxa in Neuroblastoma, Thereby Determining Bortezomib Sensitivity Independent of Prosurvival MCL1 Expression* , 2010, The Journal of Biological Chemistry.

[21]  F. White,et al.  Mcl-1 Integrates the Opposing Actions of Signaling Pathways That Mediate Survival and Apoptosis , 2009, Molecular and Cellular Biology.

[22]  M. Amiot,et al.  A pivotal role for Mcl-1 in Bortezomib-induced apoptosis , 2008, Oncogene.

[23]  G. Gores,et al.  mir-29 regulates Mcl-1 protein expression and apoptosis , 2007, Oncogene.

[24]  S. Trudel,et al.  Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. , 2007, Blood.

[25]  R. Bataille,et al.  Noxa up-regulation and Mcl-1 cleavage are associated to apoptosis induction by bortezomib in multiple myeloma. , 2007, Cancer research.

[26]  G. Tonon,et al.  Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma. , 2007, Cancer research.

[27]  T. Golub,et al.  Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. , 2006, Cancer cell.

[28]  Jeffrey Skolnick,et al.  Efficient prediction of nucleic acid binding function from low-resolution protein structures. , 2006, Journal of molecular biology.

[29]  M. Hung,et al.  Degradation of Mcl-1 by β-TrCP Mediates Glycogen Synthase Kinase 3-Induced Tumor Suppression and Chemosensitization , 2006, Molecular and Cellular Biology.

[30]  R. Bataille,et al.  Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival , 2005, Leukemia.

[31]  Xiaodong Wang,et al.  Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis , 2005, Cell.

[32]  S. Korsmeyer,et al.  Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells , 2005, Science.

[33]  R. Craig,et al.  MCLI , a gene expressed in programmed myeloid cell differentiation , has sequence similarity to BCL 2 , 2005 .

[34]  M. Amiot,et al.  1 VEGF INDUCES MCL-1 UPREGULATION AND PROTECTS MULTIPLE MYELOMA CELLS AGAINST APOPTOSIS , 2004 .

[35]  P. Auberger,et al.  Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis , 2004, Oncogene.

[36]  K. Podar,et al.  Mcl-1 Regulation and Its Role in Multiple Myeloma , 2004, Cell cycle.

[37]  Kam Y. J. Zhang,et al.  Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage , 2004, Oncogene.

[38]  J. Clohessy,et al.  Characterisation of Mcl‐1 cleavage during apoptosis of haematopoietic cells , 2004, British journal of haematology.

[39]  Søren Brunak,et al.  Analysis and prediction of leucine-rich nuclear export signals. , 2004, Protein engineering, design & selection : PEDS.

[40]  Xiao-Ming Yin,et al.  Degradation of Mcl-1 by Granzyme B , 2004, Journal of Biological Chemistry.

[41]  D. Carrasco,et al.  Identification of genes modulated in multiple myeloma using genetically identical twin samples. , 2004, Blood.

[42]  S. Korsmeyer,et al.  Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 , 2003, Nature.

[43]  J. D. Vos,et al.  A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells , 2003, Oncogene.

[44]  Burkhard Rost,et al.  The PredictProtein server , 2003, Nucleic Acids Res..

[45]  Alexander L. Dent,et al.  Repression of AP-1 Function: A Mechanism for the Regulation of Blimp-1 Expression and B Lymphocyte Differentiation by the B Cell Lymphoma-6 Protooncogene1 , 2002, The Journal of Immunology.

[46]  R. Anderson,et al.  Developmental changes in expression of myeloid cell leukemia-1 in human germ cells during oogenesis and early folliculogenesis. , 2002, The Journal of clinical endocrinology and metabolism.

[47]  R. Bataille,et al.  Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells. , 2002, Blood.

[48]  R. Bataille,et al.  IL‐6 up‐regulates Mcl‐1 in human myeloma cells through JAK / STAT rather than Ras / MAP kinase pathway , 1999, European journal of immunology.

[49]  R. Craig,et al.  MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. , 1993, Proceedings of the National Academy of Sciences of the United States of America.