Treatment planning for a radiosurgical system with general kinematics

In radiosurgery a beam of radiation is used as an ablative surgical instrument to destroy brain tumors. Treatment planning consists of computing a sequence of beam configurations for delivering a necrotic dose to the tumor, without damaging healthy tissue or particularly critical structures. In current systems, kinematic limitations severely constrain beam motion. This often results in inappropriate dose distributions. A new radiosurgical system has been implemented to overcome this disadvantage. In this system, a compact radiation source of high energy is moved by a 6-dof robotic arm. We describe algorithms for computing a motion with specified characteristics for this new system. Treatment plans used at test sites with earlier systems are compared to plans computed with the described algorithms. The experience reported shows that full kinematic flexibility combined with treatment planning algorithms allows for better protection of healthy tissue and higher dosage in tumors.<<ETX>>

[1]  L. Leksell,et al.  The High-Energy Proton Beam as a Neurosurgical Tool , 1958, Nature.

[2]  K. Winston,et al.  A system for stereotactic radiosurgery with a linear accelerator. , 1986, International journal of radiation oncology, biology, physics.

[3]  M Pla,et al.  Dynamic stereotactic radiosurgery. , 1988, International journal of radiation oncology, biology, physics.

[4]  Greg Turk,et al.  Re-tiling polygonal surfaces , 1992, SIGGRAPH.

[5]  N. Barth,et al.  An inverse problem in radiation therapy. , 1990, International journal of radiation oncology, biology, physics.

[6]  L. Desbat,et al.  Conformai external radiotherapy: Requirements and preliminary results , 1992, 1992 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[7]  文献委員会 Dynamic stereotactic radiosurgery., Podgorsak E.B., et al., Int. J. Radiation Oncology Biol. Phys., 14(1), 115-126, (1988). : 放射線治療 , 1988 .

[8]  A. Brahme,et al.  Optimization of stationary and moving beam radiation therapy techniques. , 1988, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[9]  Leonidas J. Guibas,et al.  A Singly-Expenential Stratification Scheme for Real Semi-Algebraic Varieties and Its Applications , 1989, ICALP.

[10]  Jean-Claude Latombe,et al.  Motion planning in stereotaxic radiosurgery , 1993, IEEE Trans. Robotics Autom..

[11]  A. Cormack,et al.  A problem in rotation therapy with X rays. , 1987, International journal of radiation oncology, biology, physics.

[12]  文献委員会 Measurements of Dose Distributions in Small Beams of 6 MV X-rays., Rice R.K., et al., Phys. Med. Biol., 32(9),1087-1099, (1987) : 放射線治療 , 1988 .

[13]  C Munari,et al.  Stereotactic radiosurgery with the linear accelerator: treatment of arteriovenous malformations. , 1989, Neurosurgery.