Semantic Priming and Its Link to Verbal Comprehension and Working Memory in Children with Learning Disorders

Children with learning disorders (LD children) often have heterogeneous cognitive impairments that affect their ability to learn and use basic academic skills. A proposed cause for this variability has been working memory (WM) capacity. Altered patterns of event-related potentials (ERPs) in these children have also been found in the N400 component associated with semantic priming. However, regarding the semantic priming effect in LD children, no distinction has been made for children with varying WM abilities. This study aims to explore the relationship of WM with the brain’s electrophysiological response that underlies semantic priming in LD children that performed a lexical decision task. A total of 40 children (8-10 years old) participated: 28 children with LD and 12 age-matched controls. The ERPs were recorded for each group and analyzed with permutation-based t-tests. The N400 effect was observed only in the control group, and both groups showed a late positive complex (LPC). Permutation-based regression analyses were performed for the results from the LD group using the WISC-IV indices (e.g., Verbal Comprehension and WM) as independent predictors of the ERPs. The Verbal Comprehension Index, but not the WM index, was a significant predictor of the N400 and LPC effects in LD children.

[1]  P. Boggio,et al.  Event-related potential and lexical decision task in dyslexic adults: Lexical and lateralization effects , 2022, Frontiers in Psychology.

[2]  J. Silva-Pereyra,et al.  Verbal intelligence and leisure activities are associated with cognitive performance and resting-state electroencephalogram , 2022, Frontiers in Aging Neuroscience.

[3]  G. Yener,et al.  Taxonomically-related Word Pairs Evoke both N400 and LPC at Long SOA in Turkish , 2022, Journal of Psycholinguistic Research.

[4]  American Psychiatric Association.  Diagnostic and Statistical Manual of Mental Disorders , 2022 .

[5]  L. Hasher,et al.  Default Mode Network and Neural Phase Synchronization in Healthy Aging: A Resting State EEG Study , 2022, Neuroscience.

[6]  J. Silva-Pereyra,et al.  Arithmetic processing in children with dyscalculia: an event-related potential study , 2021, PeerJ.

[7]  Rolando J. Biscay-Lirio,et al.  Working Memory in Children with Learning Disorders: An EEG Power Spectrum Analysis , 2020, Brain sciences.

[8]  A. Wróbel,et al.  Resting-state EEG activity predicts frontoparietal network reconfiguration and improved attentional performance , 2020, Scientific Reports.

[9]  Edward W. Wlotko,et al.  Going the Extra Mile: Effects of Discourse Context on Two Late Positivities During Language Comprehension , 2020, Neurobiology of Language.

[10]  K. McRae,et al.  Late positive complex in event-related potentials tracks memory signals when they are decision relevant , 2019, Scientific Reports.

[11]  J. Bosch-Bayard,et al.  Clinical and Electrophysiological Differences between Subjects with Dysphonetic Dyslexia and Non-Specific Reading Delay , 2018, Brain sciences.

[12]  Satu Palva,et al.  Gamma Oscillations Underlie the Maintenance of Feature-Specific Information and the Contents of Visual Working Memory. , 2015, Cerebral cortex.

[13]  J. Silva-Pereyra,et al.  Event-Related Brain Potentials during a Semantic Priming Task in Children with Learning Disabilities Not Otherwise Specified , 2014, PloS one.

[14]  T. Harmony.  The functional significance of delta oscillations in cognitive processing , 2013, Front. Integr. Neurosci..

[15]  K. Schuchardt,et al.  Working Memory Functioning in Children With Learning Disorders and Specific Language Impairment , 2013 .

[16]  H. Roeyers,et al.  Working Memory in Children With Reading Disabilities and/or Mathematical Disabilities , 2013, Journal of learning disabilities.

[17]  B. Pennington,et al.  Comorbidity Between Reading Disability and Math Disability , 2013, Journal of learning disabilities.

[18]  M. I. Núñez-Peña,et al.  Processing false solutions in additions: differences between high- and lower-skilled arithmetic problem-solvers , 2012, Experimental Brain Research.

[19]  Omar Mendoza-Montoya,et al.  Healthy aging: Relationship between quantitative electroencephalogram and cognition , 2012, Neuroscience Letters.

[20]  Rolando J. Biscay-Lirio,et al.  Assessing interactions in the brain with exact low-resolution electromagnetic tomography , 2011, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[21]  E. Walker,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[22]  S. Micheloyannis,et al.  What does delta band tell us about cognitive processes: A mental calculation study , 2010, Neuroscience Letters.

[23]  M. Kiefer,et al.  Attentional sensitization of unconscious cognition: task sets modulate subsequent masked semantic priming. , 2010, Journal of experimental psychology. General.

[24]  A. Grabowska,et al.  Implicit phonological and semantic processing in children with developmental dyslexia: Evidence from event-related potentials , 2010, Neuropsychologia.

[25]  D. Szűcs,et al.  Event-related brain potentials to violations of arithmetic syntax represented by place value structure , 2010, Biological Psychology.

[26]  Evelyn S. Johnson,et al.  Cognitive Processing Deficits and Students with Specific Learning Disabilities: A Selective Meta-Analysis of the Literature , 2010 .

[27]  Mario Rodríguez-Camacho,et al.  Event-related potentials findings differ between children and adults during arithmetic-fact retrieval , 2010, Neuroscience Letters.

[28]  T. Alloway.  Working Memory, but Not IQ, Predicts Subsequent Learning in Children with Learning Difficulties , 2009 .

[29]  L. Lagae.  Learning disabilities: definitions, epidemiology, diagnosis, and intervention strategies. , 2008, Pediatric clinics of North America.

[30]  J. Kaiser,et al.  Human gamma-frequency oscillations associated with attention and memory , 2007, Trends in Neurosciences.

[31]  V. Csépe,et al.  A combined event-related potential and neuropsychological investigation of developmental dyscalculia , 2007, Neuroscience Letters.

[32]  O. Jensen,et al.  Modulation of Gamma and Alpha Activity during a Working Memory Task Engaging the Dorsal or Ventral Stream , 2007, The Journal of Neuroscience.

[33]  Ulf Andersson,et al.  Working memory deficit in children with mathematical difficulties: a general or specific deficit? , 2007, Journal of experimental child psychology.

[34]  Sarah Bouaffre,et al.  Hemispheric differences in the time-course of semantic priming processes: Evidence from event-related potentials (ERPs) , 2007, Brain and Cognition.

[35]  Ekta Saroha,et al.  Lifetime Prevalence of Learning Disability Among US Children , 2007, Pediatrics.

[36]  G. Tedrus,et al.  Quantitative EEG in children with learning disabilities: analysis of band power. , 2006, Arquivos de neuro-psiquiatria.

[37]  S. Gathercole,et al.  Working memory in children with reading disabilities. , 2006, Journal of experimental child psychology.

[38]  M. Semrud-Clikeman,et al.  Neuropsychological Aspects for Evaluating Learning Disabilities , 2005, Journal of learning disabilities.

[39]  John Everatt,et al.  Working memory: its role in dyslexia and other specific learning difficulties. , 2004, Dyslexia.

[40]  Arnaud Delorme,et al.  EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis , 2004, Journal of Neuroscience Methods.

[41]  J. Bosch,et al.  N400 during lexical decision tasks: a current source localization study , 2003, Clinical Neurophysiology.

[42]  Kimitaka Kaga,et al.  Auditory lexical-semantic processing impairments in aphasic patients reflected in event-related potentials (N400). , 2003, Auris, nasus, larynx.

[43]  T. Fernández,et al.  Sources of EEG Activity in Learning Disabled Children , 2002, Clinical EEG.

[44]  Thomas E. Nichols,et al.  Nonparametric permutation tests for functional neuroimaging: A primer with examples , 2002, Human brain mapping.

[45]  E. John,et al.  The clinical role of computerized EEG in the evaluation and treatment of learning and attention disorders in children and adolescents. , 2001, The Journal of neuropsychiatry and clinical neurosciences.

[46]  T. Fernández,et al.  Delayed P300 during Sternberg and color discrimination tasks in poor readers. , 2001, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[47]  D. Francis,et al.  Persistence of dyslexia: the Connecticut Longitudinal Study at adolescence. , 1999, Pediatrics.

[48]  F Rösler,et al.  Processing of incongruous mental calculation problems: evidence for an arithmetic N400 effect. , 1999, Psychophysiology.

[49]  Daphne N. Yu,et al.  High-resolution EEG mapping of cortical activation related to working memory: effects of task difficulty, type of processing, and practice. , 1997, Cerebral cortex.

[50]  R. Stelmack,et al.  Learning disability subtypes and the effects of auditory and visual priming on visual event-related potentials to words. , 1994, Journal of clinical and experimental neuropsychology.

[51]  R. Stelmack,et al.  The effect of picture priming on event-related potentials of normal and disabled readers during a word recognition memory task. , 1990, Journal of clinical and experimental neuropsychology.

[52]  I. Böckelmann,et al.  EEG correlates of cognitive load in a multiple choice reaction task. , 2020, Acta neurobiologiae experimentalis.

[53]  Peng Peng,et al.  A Meta-Analysis on the Relation Between Reading and Working Memory , 2018, Psychological bulletin.

[54]  D. Brandeis,et al.  Frontal Midline Theta Reflects Individual Task Performance in a Working Memory Task , 2014, Brain Topography.

[55]  Christiane,et al.  World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. , 2013, JAMA.

[56]  Kara D. Federmeier,et al.  Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). , 2011, Annual review of psychology.

[57]  T. Fernández,et al.  Chapter 41 Sources of EEG activity during a verbal working memory task in adults and children , 2002 .

[58]  M. Munhoz,et al.  Cognitive potentials in children with learning disabilities. , 1997, Acta oto-laryngologica.

[59]  S. Sternberg.  Memory-scanning: mental processes revealed by reaction-time experiments. , 1969, American scientist.