Diffusion imaging concepts for clinicians

This review covers the fundamentals of diffusion tensor imaging. It is written with the clinician in mind and assumes the reader has a passing familiarity with magnetic resonance imaging (MRI). Topics covered include comparison of diffusion MRI with conventional MRI, water apparent diffusion coefficient (ADC), diffusion anisotropy, tract tracing, and changes of water apparent diffusion in response to injury. The discussion centers primarily on applications to the central nervous system, but examples from other tissues are included. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.

[1]  E. Arnoldus,et al.  A reversible posterior leukoencephalopathy syndrome. , 1996, The New England journal of medicine.

[2]  R C McKinstry,et al.  A prospective, longitudinal diffusion tensor imaging study of brain injury in newborns , 2002, Neurology.

[3]  R. Poldrack,et al.  Microstructure of Temporo-Parietal White Matter as a Basis for Reading Ability Evidence from Diffusion Tensor Magnetic Resonance Imaging , 2000, Neuron.

[4]  L. Frank.  Characterization of anisotropy in high angular resolution diffusion‐weighted MRI , 2002, Magnetic resonance in medicine.

[5]  D. Tuch.  Q‐ball imaging , 2004, Magnetic resonance in medicine.

[6]  Klaas Nicolay,et al.  DTI‐based assessment of ischemia‐reperfusion in mouse skeletal muscle , 2006, Magnetic resonance in medicine.

[7]  R. Dijkhuizen,et al.  Dynamics of cerebral tissue injury and perfusion after temporary hypoxia-ischemia in the rat: evidence for region-specific sensitivity and delayed damage. , 1998, Stroke.

[8]  Sheng-Kwei Song,et al.  Regional ventricular wall thickening reflects changes in cardiac fiber and sheet structure during contraction: quantification with diffusion tensor MRI. , 2005, American journal of physiology. Heart and circulatory physiology.

[9]  Jing-xia Xie,et al.  Functional evaluation of normothermic ischemia and reperfusion injury in dog kidney by combining MR diffusion‐weighted imaging and Gd‐DTPA enhanced first‐pass perfusion , 2003, Journal of magnetic resonance imaging : JMRI.

[10]  R. Kikinis,et al.  Microstructural brain development after perinatal cerebral white matter injury assessed by diffusion tensor magnetic resonance imaging. , 2001, Pediatrics.

[11]  R. Dijkhuizen,et al.  Changes in the Diffusion of Water and Intracellular Metabolites after Excitotoxic Injury and Global Ischemia in Neonatal Rat Brain , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[12]  A. Elster,et al.  Acute cerebral infarction: quantification of spin-density and T2 shine-through phenomena on diffusion-weighted MR images. , 1999, Radiology.

[13]  M Hoehn-Berlage,et al.  Simultaneous recording of eeg, dc potential and diffusion‐weighted nmr imaging during potassium induced cortical spreading depression in rats , 1995, NMR in biomedicine.

[14]  M E Bastin,et al.  Selecting an appropriate anisotropy index for displaying diffusion tensor imaging data with improved contrast and sensitivity , 2000, Magnetic resonance in medicine.

[15]  C. Meyer,et al.  Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in high-grade glioma. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[16]  T. Duong,et al.  Evaluation of intracellular diffusion in normal and globally‐ischemic rat brain via 133Cs NMR , 1996, Magnetic resonance in medicine.

[17]  John Russell,et al.  Dysmyelination Revealed through MRI as Increased Radial (but Unchanged Axial) Diffusion of Water , 2002, NeuroImage.

[18]  Y. Samson,et al.  False-negative diffusion-weighted MR findings in acute ischemic stroke. , 2000, AJNR. American journal of neuroradiology.

[19]  J. Kucharczyk,et al.  Early detection of regional cerebral ischemia in cats: Comparison of diffusion‐ and T2‐weighted MRI and spectroscopy , 1990, Magnetic resonance in medicine.

[20]  A. Marmarou,et al.  Characterization of edema by diffusion-weighted imaging in experimental traumatic brain injury. , 1996, Journal of neurosurgery.

[21]  Sheng-Kwei Song,et al.  Remodeling of cardiac fiber structure after infarction in rats quantified with diffusion tensor MRI. , 2003, American journal of physiology. Heart and circulatory physiology.

[22]  N. Makris,et al.  High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity , 2002, Magnetic resonance in medicine.

[23]  L H Schwamm,et al.  Ischemic stroke: effects of etiology and patient age on the time course of the core apparent diffusion coefficient. , 2001, Radiology.

[24]  T. Omae,et al.  Separating changes in the intra‐ and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain , 2002, Magnetic resonance in medicine.

[25]  P. Booker,et al.  A model to predict the histopathology of human stroke using diffusion and T2-weighted magnetic resonance imaging. , 1995, Stroke.

[26]  Jun Yoshino,et al.  Demyelination increases radial diffusivity in corpus callosum of mouse brain , 2005, NeuroImage.

[27]  S. Maier,et al.  Diffusion‐weighted MRI after cryosurgery of the canine prostate , 2003 .

[28]  J. Miller,et al.  Transient Focal Cerebral Ischemia , 2001 .

[29]  R R Edelman,et al.  Time course of the apparent diffusion coefficient (ADC) abnormality in human stroke , 1997, Neurology.

[30]  Y. Cohen,et al.  High b‐value q‐space analyzed diffusion‐weighted MRS and MRI in neuronal tissues – a technical review , 2002, NMR in biomedicine.

[31]  C. Sotak,et al.  The role of spreading depression in focal ischemia evaluated bv dffusion mapping , 1996, Annals of neurology.

[32]  E. Purcell,et al.  Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments , 1954 .

[33]  T. Duong,et al.  Evaluation of extra‐ and intracellular apparent diffusion in normal and globally ischemic rat brain via 19F NMR , 1998, Magnetic resonance in medicine.

[34]  P. Basser,et al.  Estimation of the effective self-diffusion tensor from the NMR spin echo. , 1994, Journal of magnetic resonance. Series B.

[35]  M. Solaiyappan,et al.  In vivo three‐dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging , 1999, Magnetic resonance in medicine.

[36]  Shu-Wei Sun,et al.  Differential sensitivity of in vivo and ex vivo diffusion tensor imaging to evolving optic nerve injury in mice with retinal ischemia , 2006, NeuroImage.

[37]  J. Neil,et al.  An approach to solving the dynamic range problem in measurement of the pseudodilusion coefficient in vivo with spin echoes , 1991 .

[38]  Mirza Faisal Beg,et al.  Measuring and Mapping Cardiac Fiber and Laminar Architecture Using Diffusion Tensor MR Imaging , 2005, Annals of the New York Academy of Sciences.

[39]  A. Awada,et al.  Posterior leukoencephalopathy without severe hypertension: utility of diffusion-weighted MRI. , 1999, Neurology.

[40]  J. E. Tanner,et al.  Spin diffusion measurements : spin echoes in the presence of a time-dependent field gradient , 1965 .

[41]  J D Fenstermacher,et al.  Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats , 2000, Annals of neurology.

[42]  J. Neil.  Measurement of water motion (apparent diffusion) in biologial systems , 1997 .

[43]  P. Basser,et al.  Toward a quantitative assessment of diffusion anisotropy , 1996, Magnetic resonance in medicine.

[44]  P. Grenier,et al.  MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. , 1986, Radiology.

[45]  P. Basser,et al.  In vivo fiber tractography using DT‐MRI data , 2000, Magnetic resonance in medicine.

[46]  J. Gore,et al.  Changes in water diffusion and relaxation properties of rat cerebrum during status epilepticus , 1993, Magnetic resonance in medicine.

[47]  Bradford A Moffat,et al.  The functional diffusion map: an imaging biomarker for the early prediction of cancer treatment outcome. , 2006, Neoplasia.

[48]  T E Conturo,et al.  Differences between gray matter and white matter water diffusion in stroke: diffusion-tensor MR imaging in 12 patients. , 2000, Radiology.

[49]  J. Frahm,et al.  Alteration of intracellular metabolite diffusion in rat brain in vivo during ischemia and reperfusion. , 1995, Stroke.

[50]  M. Raichle,et al.  Tracking neuronal fiber pathways in the living human brain. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[51]  Helen D'Arceuil,et al.  MR Detection of Cortical Spreading Depression Immediately after Focal Ischemia in the Rat , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[52]  A. Snyder,et al.  Radial organization of developing preterm human cerebral cortex revealed by non-invasive water diffusion anisotropy MRI. , 2002, Cerebral cortex.

[53]  C. Sotak,et al.  Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats , 1999, Annals of neurology.

[54]  R M Henkelman,et al.  A quantitative interpretation of IVIM measurements of vascular perfusion in the rat brain , 1994, Magnetic resonance in medicine.