Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia

Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini‐Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend‐level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between‐group differences in radial distance ranged between 20–30% for caudate and 5–20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend‐level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement. © 2010 Movement Disorder Society

[1]  Paul M. Thompson,et al.  Pattern of hippocampal shape and volume differences in blind subjects , 2009, NeuroImage.

[2]  S. Leh,et al.  Fronto-striatal connections in the human brain: A probabilistic diffusion tractography study , 2007, Neuroscience Letters.

[3]  Theo G. M. van Erp,et al.  A Twin Study of Genetic Contributions to Hippocampal Morphology in Schizophrenia , 2002, Neurobiology of Disease.

[4]  D. Aarsland,et al.  A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[5]  K. Jellinger.  Significance of brain lesions in Parkinson disease dementia and Lewy body dementia. , 2009, Frontiers of neurology and neuroscience.

[6]  E. Dupont,et al.  Clinical diagnosis of Parkinson's disease. Proposal of diagnostic subgroups classified at different levels of confidence , 1994, Acta neurologica Scandinavica.

[7]  K. Hugdahl,et al.  Subtypes of mild cognitive impairment in parkinson's disease: Progression to dementia , 2006, Movement disorders : official journal of the Movement Disorder Society.

[8]  Rachel L. Mistur,et al.  Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal , 2010, Neurobiology of Aging.

[9]  Paul M. Thompson,et al.  Automated Ventricular Mapping with Multi-atlas Fluid Image Alignment Reveals Genetic Effects in Alzheimer's Disease , 2007 .

[10]  Michael W. Weiner,et al.  Corrigendum to “Validation of a fully automated 3D hippocampal segmentation method using subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls” [NeuroImage 43 (2008) 59–68] , 2009, NeuroImage.

[11]  R. Barker,et al.  Movement Disorders , 1994, Stereotactic and Functional Neurosurgery.

[12]  R. Camicioli,et al.  Voxel-based morphometry reveals extra-nigral atrophy patterns associated with dopamine refractory cognitive and motor impairment in parkinsonism. , 2009, Parkinsonism & related disorders.

[13]  E. Richfield,et al.  Neurological syndrome following bilateral damage to the head of the caudate nuclei , 1987, Annals of neurology.

[14]  Kiralee M. Hayashi,et al.  3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease. , 2006, Brain : a journal of neurology.

[15]  D. Aarsland,et al.  Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study. , 2003, Archives of neurology.

[16]  Michael Weiner,et al.  and the Alzheimer’s Disease Neuroimaging Initiative* , 2007 .

[17]  G. Paulson,et al.  Magnetic resonance imaging in dementia of Parkinson's disease. , 1989, Journal of neurology, neurosurgery, and psychiatry.

[18]  Richard Camicioli,et al.  Parkinson's disease is associated with hippocampal atrophy , 2003, Movement disorders : official journal of the Movement Disorder Society.

[19]  Chi-Shing Zee,et al.  Magnetic Resonance Imaging-Based Volumetric Analysis of Basal Ganglia Nuclei and Substantia Nigra in Patients with Parkinson’s Disease , 2006, Neurosurgery.

[20]  Alan C. Evans,et al.  Cerebral atrophy and its relation to cognitive impairment in Parkinson disease , 2005, Neurology.

[21]  R. Camicioli,et al.  Posterior cingulate metabolic changes occur in Parkinson's disease patients without dementia , 2004, Neuroscience Letters.

[22]  Mario F. Mendez,et al.  Neurobehavioral changes associated with caudate lesions , 1989, Neurology.

[23]  Kiralee M. Hayashi,et al.  Dynamics of Gray Matter Loss in Alzheimer's Disease , 2003, The Journal of Neuroscience.

[24]  M. Hoehn,et al.  Parkinsonism , 1967, Neurology.

[25]  I. McKeith,et al.  Temporal lobe atrophy on MRI in Parkinson disease with dementia , 2005, Neurology.

[26]  Kiralee M. Hayashi,et al.  Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps. , 2006, Archives of neurology.

[27]  Sharon E. Lee,et al.  Ventricular volume and dementia progression in the Cardiovascular Health Study , 2007, Neurobiology of Aging.

[28]  J. Spreer,et al.  Thalamic gray matter changes in unilateral Parkinsonian resting tremor: a voxel-based morphometric analysis of 3-dimensional magnetic resonance imaging , 2002, Neuroscience Letters.

[29]  R. Leahy,et al.  Magnetic Resonance Image Tissue Classification Using a Partial Volume Model , 2001, NeuroImage.

[30]  E. Tolosa,et al.  MRI atrophy parameters related to cognitive and motor impairment in Parkinson's disease. , 2001, Neurologia.

[31]  I. McKeith,et al.  Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls. , 2004, Brain : a journal of neurology.

[32]  Dag Aarsland,et al.  Gray matter atrophy in Parkinson disease with dementia and dementia with Lewy bodies , 2007, Neurology.

[33]  Kiralee M. Hayashi,et al.  Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer disease. , 2007, Archives of neurology.

[34]  Kiralee M. Hayashi,et al.  Three-Dimensional Mapping of Hippocampal Anatomy in Unmedicated and Lithium-Treated Patients with Bipolar Disorder , 2008, Neuropsychopharmacology.

[35]  C. Summerfield,et al.  Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia , 2005, Movement disorders : official journal of the Movement Disorder Society.

[36]  C. Jack,et al.  Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD , 2004, Neurology.

[37]  V Kaasinen,et al.  Hippocampal and prefrontal atrophy in patients with early non-demented Parkinson’s disease is related to cognitive impairment , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[38]  Thomas E. Nichols,et al.  Nonparametric permutation tests for functional neuroimaging: A primer with examples , 2002, Human brain mapping.

[39]  Paul M. Thompson,et al.  Detection and mapping of hippocampal abnormalities in autism , 2006, Psychiatry Research: Neuroimaging.

[40]  P. Martínez-Martín,et al.  Unified Parkinson's disease rating scale characteristics and structure , 1994, Movement disorders : official journal of the Movement Disorder Society.